门冬氨酸鸟氨酸在国外批准国家

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Sweetman S (Ed), Martindale: The complete drug reference. London: Pharmaceutical Press. Electronic version, (2005). Ornithine

Ornithine

Drug Nomenclature

Synonyms: L -Ornithine ; α,δ-Diaminovaleric Acid; Ornitina

rINN: Ornithine

Chemical name: L -2,5-Diaminovaleric acid

Molecular formula: C 5H 12N 2O 2 =132.2

CAS: 70-26-8

Pharmacopoeias:

Ger. includes Ornithine Aspartate and Ornithine Hydrochloride.

Date of monograph revision: 14-Apr-1998; 02-Sep-1999; 30-Oct-2001; 25-May-2004;

Drug Profile

Ornithine is an aliphatic amino acid. It is used as a dietary supplement.

The aspartate, hydrochloride, and oxoglurate (ornithine ketoglutarate) have been used in various indications including the treatment of hyperammonaemia (

) and hepatic encephalopathy ().

References.

1. Kircheis G, et al. Therapeutic efficacy of L -ornithine -L-aspartate infusions in patients with cirrhosis and hepatic

encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 1997; 25: 1351–60. PubMed

2. Stauch S, et al. Oral L -ornithine -L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-

controlled double-blind study. J Hepatol 1998; 28: 856–64. PubMed

3. Rapport L, Lockwood B. Ornithine ketoglutarate. Pharm J 2001; 266: 688–90. Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Austria : Cere ; Hepa ; Ornicetil ; Braz.: Hepa-Merz¤; Chile : Hepa-Merz ; Fr.: Cetornan ; Ornicetil ; Ger.: Hepa-Merz KT ; Hepa-Merz ; Hepa-Vibolex ; Ornicetil¤; Hong Kong : Hepa-Merz ; Hung.: Hepa-Merz ; India : Hepa-Merz ; Ital.: Ornicetil S¤; Ornicetil ; Ornil KGF ; Ornil ; Spain : Ornicetil¤; Switz.: Ornicetil¤;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Austral.: Anti-Flab¤; Braz.: Necroplex¤; Ornihepat ; Ornitargin ; Fr.: Arnilose¤; Epuram ; Ornitaine ; Ger.: Hepa-Merz

Sub-sections Drug Nomenclature Drug Profile

Preparations

S¤; Hepa-Merz¤; Polilevo N; Polilevo¤; India: Hepa-Merz; Hepa-Merz; Ital.: Citruplexina¤; Ipoazotal Complex; Ipoazotal; Polilevo; Somatron; Spain: Sedionbel¤; UK: Slimswift Night Trim¤;

Kolassa (Austria)

Active ingredients:

z Ornithine aspartate (refer to Ornithine ) Indications: Hepatic encephalopathy