兔眼睑伤口闭合采用氰基丙烯酸酯医用胶与传统缝线的比较

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实验室研究
A Comparison of Darfox Cyanoacrylate Adhesives versus Conventional Suture Materials for Eyelid Wound Closure in Rabbits 兔眼睑伤口闭合采用氰基丙烯酸酯大耳狐医用胶与 传统缝线的比较
主要研究结果：
兔眼睑外科手术及缝线缝合、医用胶粘合 图 1：外科手术。 (A)约 15 毫米的眼睑切口。(B)切口用棉签擦干。皮下组织用剪刀进行分离。(C) 沿切口边缘涂上一层薄薄的医用胶。(D)B 组，7-0 尼龙线缝合的形式。在切口 边缘两侧 2 毫米，取样进行双盲组织病理学评价。 说明：研究对象包括 8 只 2-3 公斤的新西兰白兔，16 个眼睑。50 毫克的盐酸氯 胺酮和甲苯噻嗪盐酸盐肌注麻醉。切口的地方被剃光兔毛，和一个 15 毫米的皮 肤切口，距离眼睑四周 4 毫米(图 1A)。缝合后，给予妥布霉素眼膏，每天两次； 肌注 80 毫克庆大霉素。
Βιβλιοθήκη Baidu
Hee-Bae Ahn, Dong-Min Shin, Mee-Sook Roh, Woo-Jin Jeung, Woo-Chan Park, and Sae-Heun Rho. Korean J Ophthalmol. 2011 Apr; 25(2): 121–127. Key words: darfox adhesive, eyelid surgery, suture
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23. Quinn J, Lowe L, Mertz M. The effect of a new tissue-adhesive wound dressing on the healing of traumatic abrasions. Dermatology. 2000;201:343–346. 24. Davis SC, Eaglstein WH, Cazzaniga AL, Mertz PM. An octyl-2-cyanoacrylate formulation speeds healing of partial-thickness
研究摘要
背景：
在经过金黄色葡萄球菌污染的豚鼠皮 肤伤口上，比较医用胶和缝线的效果， 结果显示，医用胶显著降低伤口感染 发生率。本文对通过对兔眼睑伤口采 用氰基丙烯酸酯大耳狐医用胶与传统 缝线，从外观学、临床学及组织学对 伤口愈合进行评价。
目的：
评价和评价氰基丙烯酸酯医用胶和传 统缝线对兔眼睑伤口闭合的病理和的 临床疗效。
结论：
方法：
对 8 只新西兰兔(16 个眼睑)进行实，眼 睑切口长 15 毫米，距离睑缘 4 毫米。 切口分为两组，右眼睑切口用氰基丙 烯酸酯大耳狐医用胶封闭(A 组)，左眼 睑切口用 7-0 尼龙线缝合(B 组)。术后 第 1、2、4 和 8 周，对家兔眼睑伤口 愈合情况进行肉眼检查。然后处死，
研究证明，氰基丙烯酸酯医用胶是一 种有效的眼睑伤口闭合方法，具有很 好的耐受性。对于眼睑伤口，氰基丙 烯酸酯医用胶可以替代传统缝线缝 合。
wounds. Dermatol Surg. 2001;27:783–788. 25. Singer AJ, Nable M, Cameau P, et al. Evaluation of a new liquid occlusive dressing for excisional wounds. Wound Repair Regen. 2003;11:181–187.
眼睑组织标本经 HE 染色(苏木精-伊 红染色，细胞染色)和马松三色染色 (显示软组织中的纤维)，显微镜下观 察。
结果：
两组的临床疗效相似。组织病理学检 查结果中，HE 染色显示，2 周的时候， A 组比 B 组的炎性浸润更少。两组之 间组织病理学在第 1，4，和 8 周没有 显著差异。马松三色染色显示，两组 的纤维化程度在 8 周相似。