经皮给药系统的发展史
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Device-assisted transdermal drug delivery
/10.1016/j.addr.2017.08.009
IF: 15.519;Advanced Drug Delivery Reviews
Content
1. Introduction
2. The first generation
3. The second generation
4. The third generation
5. The fourth generation
6. Conclusion
Introduction
Advantages lower dosage of drugs
circumvent side effects
repeated administrations
disadvantages
stratum corneum (obstacle)
degraded by epidermal enzymes
The first generation
Simple patches loaded with drug
The second generation
Seek to maximize drug permeability
The second generation ——
examples
(1)
(2)
(3)
More Less
(4)
(5)
The third generation
Minimal epidermal disruption
The third generation ——examples
(1)
(2)
(3)100-500 kHz
The fourth generation
Wearable & Detection
The fourth generation ——examples 1
Transdermal drug delivery based on physiological/electrophysiological monitoring
Silicon membrane-based
strain gauges Collect signals & Operate
Transdermal drug delivery based on biochemical signal monitoring
Smart microneedle systems (1)(2)
Conclusion
Future transdermal drug delivery
Thank You
Thank You