Inotilone_环氧合酶(COX)抑制剂_906366-79-8_Apexbio
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参考文献: [1] Huang GJ, Huang SS, Deng JS. Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo. PLoS One. 2012;7(5):e35922.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Neuroscience
信号通路:
COX
产品描述:
IC50: 0.03 and 0.36 μM for COX-2 and COX-1, respectively Inotilone is a cyclooxygenase (COX) inhibitor. Many of nonsteroidal anti-inflammatory drugs (NSAIDs) target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid. In vitro: Inotilone was tested as the inhibitor of mitogen-activated protein kinase, nuclear
factor-κB (NF-κB), and matrix-metalloproteinase (MMP)-9 protein expressions in LPS-stimulated RAW264.7 cells. When RAW264.7 macrophages were treated with inotilone with LPS, a significant concentration-dependent inhibition of NO production was detected. It was also found that inotilone could block the protein expression of iNOS, NF-κB, and MMP-9 in LPS-stimulated RAW264.7 macrophages [1]. In vivo: In in vivo tests, inotilone decreased the paw edema after Carr administration, and it increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Inotilone also significantly attenuated the malondialdehyde (MDA) level in the edema paw. Inotilone decreased the NO and tumor necrosis factor (TNF-α) levels on serum after Carr injection. In addition, an intraperitoneal injection treatment with inotilone could diminish neutrophil infiltration into sites of inflammation, as did indomethacin [1]. Clinical trial: So far, no clinical study has been conducted.
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式:
Inotilone 906366-79-8 218.2 C12H10O4
产品名: Inotilone 修订日期: 6/30/2016
化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone
ApexBio Technology
Hale Waihona Puke Baidu
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Neuroscience
信号通路:
COX
产品描述:
IC50: 0.03 and 0.36 μM for COX-2 and COX-1, respectively Inotilone is a cyclooxygenase (COX) inhibitor. Many of nonsteroidal anti-inflammatory drugs (NSAIDs) target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid. In vitro: Inotilone was tested as the inhibitor of mitogen-activated protein kinase, nuclear
factor-κB (NF-κB), and matrix-metalloproteinase (MMP)-9 protein expressions in LPS-stimulated RAW264.7 cells. When RAW264.7 macrophages were treated with inotilone with LPS, a significant concentration-dependent inhibition of NO production was detected. It was also found that inotilone could block the protein expression of iNOS, NF-κB, and MMP-9 in LPS-stimulated RAW264.7 macrophages [1]. In vivo: In in vivo tests, inotilone decreased the paw edema after Carr administration, and it increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Inotilone also significantly attenuated the malondialdehyde (MDA) level in the edema paw. Inotilone decreased the NO and tumor necrosis factor (TNF-α) levels on serum after Carr injection. In addition, an intraperitoneal injection treatment with inotilone could diminish neutrophil infiltration into sites of inflammation, as did indomethacin [1]. Clinical trial: So far, no clinical study has been conducted.
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式:
Inotilone 906366-79-8 218.2 C12H10O4
产品名: Inotilone 修订日期: 6/30/2016
化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone
ApexBio Technology
Hale Waihona Puke Baidu
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.