Reactor Anti-Neutrino Oscillations and Gadolinium Loaded Super-Kamiokande Detector
大亚湾中微子实验结果的简单解释
大亚湾中微子实验结果的简单解释The topic I have chosen is: A simplified explanation of the results from the Daya Bay neutrino experiment.中微子是一种基本粒子,没有电荷而且质量很小。
由于其特殊性质,它们对我们理解宇宙和基本物理有着重要的意义。
大亚湾中微子实验是一个为了研究中微子性质而进行的重要实验。
它位于中国广东省深圳市附近的大亚湾核电站附近。
Neutrinos are elementary particles that have no charge and very little mass. Due to their unique properties, they hold great significance in our understanding of the universe and fundamental physics. The Daya Bay experiment is a crucial endeavor aimed at studying the properties of neutrinos. Itis located near the Daya Bay Nuclear Power Station in Shenzhen, Guangdong Province, China.该实验涉及到三个地下探测台站,每个都装备了一套灵敏的中微子探测器。
在这些探测器之间设置了远距离的干涉装置,以观察中微子的变化。
大亚湾实验主要关注两种类型的中微子:电子型中微子和反电子型中微子。
The experiment involves three underground detector stations, each equipped with a set of sensitive neutrino detectors. Long-baseline detectors are placed between these stationsto observe neutrino oscillations. The primary focus of the Daya Bay experiment is on two types of neutrinos: electron neutrinos and antineutrinos.根据量子力学的原理,中微子在运动过程中会发生一种叫做“中微子振荡”的现象。
人参皂苷治疗骨性关节炎的研究进展
特产研究163Special Wild Economic Animal and Plant ResearchDOI:10.16720/ki.tcyj.2023.093人参皂苷治疗骨性关节炎的研究进展郭校妍1,张伟东1,张扬1※(吉林大学药学院,吉林长春130021)摘要:人参在防治关节软骨损伤退变及参与体外培养软骨细胞修复关节软骨缺损中具有较好治疗前景。
人参皂苷作为人参的主要药理活性成分,在治疗骨性关节炎的进程中发挥关键作用。
人参皂苷根据不同的结构被分为不同的类型,各类型均含有多种人参皂苷单体成分,其治疗骨性关节炎的机制也各不相同。
本文对不同人参皂苷单体治疗骨性关节炎的研究进行梳理和总结,探讨其治疗骨性关节炎的潜在可能性和作用机制,为后期临床应用提供依据。
关键词:骨性关节炎;人参皂苷;信号通路中图分类号:R285文献标识码:A文章编号:1001-4721(2023)03-0163-06Research Progress of Ginsenosides in the Treatment of OsteoarthritisGUO Xiaoyan1,ZHANG Weidong1,ZHANG Yang1※(School of Pharmaceutical Sciences,Jilin University,Changchun130021,China)Abstract:Ginseng has pharmacological effects such as anti-inflammatory,antioxidant,antidepressant,anti-Alzheimer's and anti-athero-sclerosis.Current studies have found that it has good therapeutic prospects in preventing degeneration of articular cartilage damage and parti-cipating in in vitro culture of chondrocytes to repair articular cartilage defects.Ginsenosides,as the main pharmacological active component of ginseng,also play an important role in the process of treating osteoarthritis.Ginsenosides can be classified into different types because of their different structures,and each type contains a variety of ginsenoside monomer components with different mechanisms for the treatment of osteoarthritis.In this paper,we review the research progress of different ginsenoside monomers in the treatment of osteoarthritis,and ex-plore their potential possibilities and mechanisms for the treatment of osteoarthritis,so as to provide a basis for later clinical application. Key words:osteoarthritis;ginsenosides;signaling pathway骨性关节炎(Osteoarthritis,OA)是一种退行性病变,系由于增龄、肥胖、遗传、劳损、创伤、关节先天性异常和关节畸形等诸多因素引起的关节软骨退化损伤、关节边缘和软骨下骨反应性增生。
雷公藤内酯醇对阿尔茨海默病模型大鼠海马突触素表达及突触超微结构的影响
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( 南昌大学医学院解剖 学教研室 ,南 昌 30 0 ) 3 0 6
摘要 目的: 探讨雷公藤 内酯醇对 阿尔茨海默病模型大 鼠海马突触素表达及 突触超微 结构 的影 响。方法 : 鼠随机 分成对 大
照组、 模型组 、 治疗组 。模 型组给予 双侧海 马各一次性注射凝 聚态 A 。 0 , 1 g 治疗 组在海 马注射凝 聚态 A 。 , 日腹 后 每
腔注射雷公藤 内酯醇 0 4rg k ,1 . / g 5 a d后用免疫组织化学方法和蛋白免疫印迹技 术检 测海 马突触 素表 达情况 , 透射 电镜观 察 突触结构 的变化 。结果 : 与模 型组 相 比, 治疗 组海 马 区突触 素免疫 反应 阳性 产物 数量 ( 5 . 0 5 7 ) 1 28 士1 .6 及平 均光 密度 ( . 1 ±0 078 均增加 ; O38 O . 2 ) 突触素表达总量 ( 1 . 1 -1 0 ) 1 7 7 44 . 2及密度 比值 (. 7 . 3 亦增加 ; 9 O 8 ±0 0 ) 突触结构较清 晰 , 界面增 长, 突触后 电子致 密物增厚 。结论 : 雷公藤 内酯醇 可以增加 阿尔 茨海默病 模型大 鼠海马突触 素 的表 达 , 轻阿尔茨 海默病 减 模 型大 鼠海马突触损伤程度 。 关键词 雷公藤 内酯醇 ;阿尔茨海 默病 ; 突触素 ; 突触 ; 马 ; 鼠 海 大
依达拉奉右莰醇注射液对急性前循环脑梗死血管介入术后开通良好患者的脑保护作用
ing in treatment of chronic heart failure patient [J].Chinese Journal of General Practice,2020,18(9):1504-1507,1550.陈远园,刘庆生,彭伟献,等.益气化瘀汤辅助治疗对慢性心力衰竭患者微血管损伤和心室重构及代谢重构的影响[J].中华全科医学,2020,18(9):1504-1507,1550.[25]Blanda V ,Bracale UM,Di Taranto MD,et al.Galectin -3in cardio-vascular diseases [J].Int J Mol Sci,2020,21(23):9232.[26]Rabkin SW,Tang JKK.The utility of growth differentiation fac-tor -15,galectin -3,and sST2as biomarkers for the diagnosis of heart failure with preserved ejection fraction and compared to heart failure with reduced ejection fraction:a systematic review [J].Heart Fail Rev,2021,26(4):799-812.[27]Ye S,Luo W,Khan ZA,et al.Celastrol attenuates angiotensin Ⅱ-in-duced cardiac remodeling by targeting STAT3[J].Circ Res,2020,126(8):1007-1023.[28]Dai C,Luo W,Chen Y ,et al.Tabersonine attenuates angiotensin Ⅱ-in-duced cardiac remodeling and dysfunction through targeting TAK1and inhibiting TAK1-mediated cardiac inflammation [J].Phytomedi-cine,2022,103(1):154238.[29]Gu J,Qiu M,Lu Y ,et al.Piperlongumine attenuates angiotensin -Ⅱ-in-duced cardiac hypertrophy and fibrosis by inhibiting Akt-FoxO1sig-nalling [J].Phytomedicine,2021,82(1):153461.[30]Nie YY ,Song YL,Lu YH,et al.The effect of Xinbao pill and Wulingpowder on serum ang Ⅱand Gal -3protein levels in chronic heart fail-ure patients with Yang Deficiency and Water Pan syndrome [J].Chi-nese Archives of Traditional Chinese Medicine,2022,40(12):222-225.聂颖颖,宋业琳,卢英红,等.心宝丸合五苓散对阳虚水泛型慢性心力衰竭血清Ang Ⅱ、Gal -3蛋白水平的影响[J].中华中医药学刊,2022,40(12):222-225.(收稿日期:2023-09-26)依达拉奉右莰醇注射液对急性前循环脑梗死血管介入术后开通良好患者的脑保护作用高亚军1,宋倩2,刘春霞3,吴瑞1,郭改艳1延安大学附属医院神经内科1、检验科2、放射科3,陕西延安716000【摘要】目的研究依达拉奉右莰醇注射液对急性前循环脑梗死血管介入术后开通良好患者的脑保护作用。
达那唑-酪蛋白酸钠复合纳米粒的制备及其形成机制研究
达那唑-酪蛋白酸钠复合纳米粒的制备及其形成机制研究作者:李佳雯曹文峰徐浩冯予涵冷钰婷景秋芳任福正来源:《中国药房》2022年第10期中图分类号 R944 文献标志码 A 文章编号 1001-0408(2022)10-1213-08DOI 10.6039/j.issn.1001-0408.2022.10.10摘要目的制备并表征达那唑(DAZ)-酪蛋白酸钠(SC)复合纳米粒,探讨“自下而上(bottom-up)”工艺中纳米粒形成的机制。
方法以SC作为调控纳米粒的稳定剂,通过反溶剂沉淀法制备DAZ-SC复合纳米粒,对其粒径、Zeta电位、微观形态、稳定性、包封率、载药量、体外溶出度等进行表征,进一步利用荧光光谱、红外光谱和在线粒子监测等方法分析DAZ与SC的相互作用机制。
结果 DAZ-SC复合纳米粒的粒径为(223.7±12.5) nm,多分散性指数为0.274±0.012,Zeta电位为-(17.81±1.63) mV(n=3);纳米混悬液的稳定性良好,DAZ 的固态性质明显改善,溶出度显著提高。
SC在DAZ的作用下发生静态淬灭,二级结构有所改变;在SC的作用下,DAZ的结晶过程得到控制;DAZ与SC之间的相互作用主要为氢键和范德华力。
结论本研究成功制备了DAZ-SC复合纳米粒;在“bottom-up”工艺中,因SC与DAZ之间氢键和范德华力引起的相互作用抑制了药物晶体的生长与团聚。
关键词达那唑;酪蛋白酸钠;稳定剂;形成机制;纳米粒Study on preparation and formation mechanism of danazol-sodium caseinate composite nanoparticlesLI Jiawen,CAO Wenfeng,XU Hao,FENG Yuhan,LENG Yuting,JING Qiufang,REN Fuzheng(Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China)ABSTRACT OBJECTIVE To prepare and characterize danazol (DAZ)-sodium caseinate (SC) composite nanoparticles, and to study the mechanism of preparing nanoparticles in “bottom-up” technology. METHODS SC was used as a stabilizer for re gulating nanoparticles, so that DAZ-SC composite nanoparticles were prepared by anti-solvent precipitation method. The particle size, Zeta-potential, micro-morphology, stability, encapsulation efficiency, drug loading and in vitro dissolution rate were characterized. Fluorescence spectra, IR spectra, FBRM and other methods were used to analyze the interaction mechanism between DAZ and SC. RESULTS The particle size of DAZ-SC composite nanoparticles was (223.7±12.5) nm, and the polydispersity index was 0.274±0.012. Zeta-potential was -(17.81±1.63) mV (n=3). The stability of nano-suspension was good, the solid properties of DAZ were greatly improved,and the dissolution rate was significantly increased. SC was statically quenched under the action of DAZ and the secondary structures of SC were changed. The crystallization process of DAZ was controlled under the action of SC,and the interaction between DAZ and SC was mainly hydrogen bond and van der Waals force. CONCLUSIONS In this study, DAZ-SC composite nanoparticles are successfully prepared. In the “bottom-up” technology, the interaction between SC and DAZ caused by hydrogen bond and van der Waals force inhibits the growth and agglomeration of drug crystals.KEYWORDS danazol; sodium caseinate; stabilizer; formation mechanism; nanoparticles根據Noyes-Whitney方程可知,难溶性药物颗粒尺寸的减小可提高其溶出度[1],因此减小粒径的方法被广泛应用于难溶性药物的制剂领域[2]。
替考拉宁和万古霉素高效液相色谱手性固定相的研究
替考拉宁和万古霉素高效液相色谱手性固定相的研究
刘金月;苏鹏;祝金艳;艾萍;袁黎明
【期刊名称】《化学研究》
【年(卷),期】2022(33)2
【摘要】分别使用四种不同的方法将替考拉宁和万古霉素键合在硅胶表面,制备了八种不同的高效液相色谱柱固定相,并在反相模式和极性有机相模式下考察了这八种手性柱的性能。
实验表明,固定相制备方法的不同和色谱条件的改变对色谱柱拆分性能有一定的影响,不相同的键合臂,能拆分的对映异构体可能不一样,这些柱之间具有一定的互补性。
八种手性固定相均有一定的手性拆分效果,特别是对α-氨基酸及其衍生物具有较好的手性识别能力,所制备的手性柱可用在高效液相色谱法拆分手性化合物中。
【总页数】7页(P136-142)
【作者】刘金月;苏鹏;祝金艳;艾萍;袁黎明
【作者单位】云南师范大学化学化工学院
【正文语种】中文
【中图分类】O657.7
【相关文献】
1.高效液相色谱-串联质谱测定猪肉中万古霉素、去甲万古霉素和替考拉宁
2.高效液相色谱手性固定相的研究Ⅴ——二肽叔丁酰胺型手性固定相拆分α-氨基酸、二茂铁基氨基酸及二肽衍生物对映异构体
3.替考拉宁高效液相色谱手性固定相的制
备研究4.高效液相色谱手性固定相的研究Ⅳ.(L,L)-二肽叔丁酰胺型手性固定相拆分α-氨基烃基膦酸衍生物对映异构体5.高效液相色谱手性固定相的研究Ⅵ.间隔基结构对L-缬氨酸叔丁酰胺型手性固定相拆分效果的影响
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Can neutrinos be unified with quarks
Can neutrinos be unified with quarks ?
邓建儒 2012141441300 电气信息学院 In my opinion, neutrinos cannot be unified with quarks.
Neutrino
1. Theories about neutrino: Pauli's proposal The neutrino was postulated first by Wolfgang Pauli in 1930 to explain how beta decay could conserve energy, momentum, and angular momentum (spin). Pauli hypothesized an undetected particle that he called a "neutron" in keeping with convention employed for naming both the proton and the electron, which in 1930 were known to be respective products for alpha and beta decay. He considered that the new particle was emitted from the nucleus together with the electron or beta particle in the process of beta decay. Fermi’s theory Enrico Fermi, who developed the theory of beta decay, coin
量子力学索引英汉对照
21-centimeter line, 21厘米线AAbsorption, 吸收Addition of angular momenta, 角动量叠加Adiabatic approximation, 绝热近似Adiabatic process, 绝热过程Adjoint, 自伴的Agnostic position, 不可知论立场Aharonov-Bohm effect, 阿哈罗诺夫-玻姆效应Airy equation, 艾里方程;Airy function, 艾里函数Allowed energy, 允许能量Allowed transition, 允许跃迁Alpha decay, 衰变;Alpha particle, 粒子Angular equation, 角向方程Angular momentum, 角动量Anomalous magnetic moment, 反常磁矩Antibonding, 反键Anti-hermitian operator, 反厄米算符Associated Laguerre polynomial, 连带拉盖尔多项式Associated Legendre function, 连带勒让德多项式Atoms, 原子Average value, 平均值Azimuthal angle, 方位角Azimuthal quantum number, 角量子数BBalmer series, 巴尔末线系Band structure, 能带结构Baryon, 重子Berry's phase, 贝利相位Bessel functions, 贝塞尔函数Binding energy, 束缚能Binomial coefficient, 二项式系数Biot-Savart law, 毕奥-沙法尔定律Blackbody spectrum, 黑体谱Bloch's theorem, 布洛赫定理Bohr energies, 玻尔能量;Bohr magneton, 玻尔磁子;Bohr radius, 玻尔半径Boltzmann constant, 玻尔兹曼常数Bond, 化学键Born approximation, 玻恩近似Born's statistical interpretation, 玻恩统计诠释Bose condensation, 玻色凝聚Bose-Einstein distribution, 玻色-爱因斯坦分布Boson, 玻色子Bound state, 束缚态Boundary conditions, 边界条件Bra, 左矢Bulk modulus, 体积模量CCanonical commutation relations, 正则对易关系Canonical momentum, 正则动量Cauchy's integral formula, 柯西积分公式Centrifugal term, 离心项Chandrasekhar limit, 钱德拉赛卡极限Chemical potential, 化学势Classical electron radius, 经典电子半径Clebsch-Gordan coefficients, 克-高系数Coherent States, 相干态Collapse of wave function, 波函数塌缩Commutator, 对易子Compatible observables, 对易的可观测量Complete inner product space, 完备内积空间Completeness, 完备性Conductor, 导体Configuration, 位形Connection formulas, 连接公式Conservation, 守恒Conservative systems, 保守系Continuity equation, 连续性方程Continuous spectrum, 连续谱Continuous variables, 连续变量Contour integral, 围道积分Copenhagen interpretation, 哥本哈根诠释Coulomb barrier, 库仑势垒Coulomb potential, 库仑势Covalent bond, 共价键Critical temperature, 临界温度Cross-section, 截面Crystal, 晶体Cubic symmetry, 立方对称性Cyclotron motion, 螺旋运动DDarwin term, 达尔文项de Broglie formula, 德布罗意公式de Broglie wavelength, 德布罗意波长Decay mode, 衰变模式Degeneracy, 简并度Degeneracy pressure, 简并压Degenerate perturbation theory, 简并微扰论Degenerate states, 简并态Degrees of freedom, 自由度Delta-function barrier, 势垒Delta-function well, 势阱Derivative operator, 求导算符Determinant, 行列式Determinate state, 确定的态Deuterium, 氘Deuteron, 氘核Diagonal matrix, 对角矩阵Diagonalizable matrix, 对角化Differential cross-section, 微分截面Dipole moment, 偶极矩Dirac delta function, 狄拉克函数Dirac equation, 狄拉克方程Dirac notation, 狄拉克记号Dirac orthonormality, 狄拉克正交归一性Direct integral, 直接积分Discrete spectrum, 分立谱Discrete variable, 离散变量Dispersion relation, 色散关系Displacement operator, 位移算符Distinguishable particles, 可分辨粒子Distribution, 分布Doping, 掺杂Double well, 双势阱Dual space, 对偶空间Dynamic phase, 动力学相位EEffective nuclear charge, 有效核电荷Effective potential, 有效势Ehrenfest's theorem, 厄伦费斯特定理Eigenfunction, 本征函数Eigenvalue, 本征值Eigenvector, 本征矢Einstein's A and B coefficients, 爱因斯坦A,B系数;Einstein's mass-energy formula, 爱因斯坦质能公式Electric dipole, 电偶极Electric dipole moment, 电偶极矩Electric dipole radiation, 电偶极辐射Electric dipole transition, 电偶极跃迁Electric quadrupole transition, 电四极跃迁Electric field, 电场Electromagnetic wave, 电磁波Electron, 电子Emission, 发射Energy, 能量Energy-time uncertainty principle, 能量-时间不确定性关系Ensemble, 系综Equilibrium, 平衡Equipartition theorem, 配分函数Euler's formula, 欧拉公式Even function, 偶函数Exchange force, 交换力Exchange integral, 交换积分Exchange operator, 交换算符Excited state, 激发态Exclusion principle, 不相容原理Expectation value, 期待值FFermi-Dirac distribution, 费米-狄拉克分布Fermi energy, 费米能Fermi surface, 费米面Fermi temperature, 费米温度Fermi's golden rule, 费米黄金规则Fermion, 费米子Feynman diagram, 费曼图Feynman-Hellman theorem, 费曼-海尔曼定理Fine structure, 精细结构Fine structure constant, 精细结构常数Finite square well, 有限深方势阱First-order correction, 一级修正Flux quantization, 磁通量子化Forbidden transition, 禁戒跃迁Foucault pendulum, 傅科摆Fourier series, 傅里叶级数Fourier transform, 傅里叶变换Free electron, 自由电子Free electron density, 自由电子密度Free electron gas, 自由电子气Free particle, 自由粒子Function space, 函数空间Fusion, 聚变Gg-factor, g-因子Gamma function, 函数Gap, 能隙Gauge invariance, 规范不变性Gauge transformation, 规范变换Gaussian wave packet, 高斯波包Generalized function, 广义函数Generating function, 生成函数Generator, 生成元Geometric phase, 几何相位Geometric series, 几何级数Golden rule, 黄金规则"Good" quantum number, "好"量子数"Good" states, "好"的态Gradient, 梯度Gram-Schmidt orthogonalization, 格莱姆-施密特正交化法Graphical solution, 图解法Green's function, 格林函数Ground state, 基态Group theory, 群论Group velocity, 群速Gyromagnetic railo, 回转磁比值HHalf-integer angular momentum, 半整数角动量Half-life, 半衰期Hamiltonian, 哈密顿量Hankel functions, 汉克尔函数Hannay's angle, 哈内角Hard-sphere scattering, 硬球散射Harmonic oscillator, 谐振子Heisenberg picture, 海森堡绘景Heisenberg uncertainty principle, 海森堡不确定性关系Helium, 氦Helmholtz equation, 亥姆霍兹方程Hermite polynomials, 厄米多项式Hermitian conjugate, 厄米共轭Hermitian matrix, 厄米矩阵Hidden variables, 隐变量Hilbert space, 希尔伯特空间Hole, 空穴Hooke's law, 胡克定律Hund's rules, 洪特规则Hydrogen atom, 氢原子Hydrogen ion, 氢离子Hydrogen molecule, 氢分子Hydrogen molecule ion, 氢分子离子Hydrogenic atom, 类氢原子Hyperfine splitting, 超精细分裂IIdea gas, 理想气体Idempotent operaror, 幂等算符Identical particles, 全同粒子Identity operator, 恒等算符Impact parameter, 碰撞参数Impulse approximation, 脉冲近似Incident wave, 入射波Incoherent perturbation, 非相干微扰Incompatible observables, 不对易的可观测量Incompleteness, 不完备性Indeterminacy, 非确定性Indistinguishable particles, 不可分辨粒子Infinite spherical well, 无限深球势阱Infinite square well, 无限深方势阱Inner product, 内积Insulator, 绝缘体Integration by parts, 分部积分Intrinsic angular momentum, 内禀角动量Inverse beta decay, 逆衰变Inverse Fourier transform, 傅里叶逆变换KKet, 右矢Kinetic energy, 动能Kramers' relation, 克莱默斯关系Kronecker delta, 克劳尼克LLCAO technique, 原子轨道线性组合法Ladder operators, 阶梯算符Lagrange multiplier, 拉格朗日乘子Laguerre polynomial, 拉盖尔多项式Lamb shift, 兰姆移动Lande g-factor, 朗德g-因子Laplacian, 拉普拉斯的Larmor formula, 拉摩公式Larmor frequency, 拉摩频率Larmor precession, 拉摩进动Laser, 激光Legendre polynomial, 勒让德多项式Levi-Civita symbol, 列维-西维塔符号Lifetime, 寿命Linear algebra, 线性代数Linear combination, 线性组合Linear combination of atomic orbitals, 原子轨道的线性组合Linear operator, 线性算符Linear transformation, 线性变换Lorentz force law, 洛伦兹力定律Lowering operator, 下降算符Luminoscity, 照度Lyman series, 赖曼线系MMagnetic dipole, 磁偶极Magnetic dipole moment, 磁偶极矩Magnetic dipole transition, 磁偶极跃迁Magnetic field, 磁场Magnetic flux, 磁通量Magnetic quantum number, 磁量子数Magnetic resonance, 磁共振Many worlds interpretation, 多世界诠释Matrix, 矩阵;Matrix element, 矩阵元Maxwell-Boltzmann distribution, 麦克斯韦-玻尔兹曼分布Maxwell's equations, 麦克斯韦方程Mean value, 平均值Measurement, 测量Median value, 中位值Meson, 介子Metastable state, 亚稳态Minimum-uncertainty wave packet, 最小不确定度波包Molecule, 分子Momentum, 动量Momentum operator, 动量算符Momentum space wave function, 动量空间波函数Momentum transfer, 动量转移Most probable value, 最可几值Muon, 子Muon-catalysed fusion, 子催化的聚变Muonic hydrogen, 原子Muonium, 子素NNeumann function, 纽曼函数Neutrino oscillations, 中微子振荡Neutron star, 中子星Node, 节点Nomenclature, 术语Nondegenerate perturbationtheory, 非简并微扰论Non-normalizable function, 不可归一化的函数Normalization, 归一化Nuclear lifetime, 核寿命Nuclear magnetic resonance, 核磁共振Null vector, 零矢量OObservable, 可观测量Observer, 观测者Occupation number, 占有数Odd function, 奇函数Operator, 算符Optical theorem, 光学定理Orbital, 轨道的Orbital angular momentum, 轨道角动量Orthodox position, 正统立场Orthogonality, 正交性Orthogonalization, 正交化Orthohelium, 正氦Orthonormality, 正交归一性Orthorhombic symmetry, 斜方对称Overlap integral, 交叠积分PParahelium, 仲氦Partial wave amplitude, 分波幅Partial wave analysis, 分波法Paschen series, 帕邢线系Pauli exclusion principle, 泡利不相容原理Pauli spin matrices, 泡利自旋矩阵Periodic table, 周期表Perturbation theory, 微扰论Phase, 相位Phase shift, 相移Phase velocity, 相速Photon, 光子Planck's blackbody formula, 普朗克黑体辐射公式Planck's constant, 普朗克常数Polar angle, 极角Polarization, 极化Population inversion, 粒子数反转Position, 位置;Position operator, 位置算符Position-momentum uncertainty principles, 位置-动量不确定性关系Position space wave function, 坐标空间波函数Positronium, 电子偶素Potential energy, 势能Potential well, 势阱Power law potential, 幂律势Power series expansion, 幂级数展开Principal quantum number, 主量子数Probability, 几率Probability current, 几率流Probability density, 几率密度Projection operator, 投影算符Propagator, 传播子Proton, 质子QQuantum dynamics, 量子动力学Quantum electrodynamics, 量子电动力学Quantum number, 量子数Quantum statics, 量子统计Quantum statistical mechanics, 量子统计力学Quark, 夸克RRabi flopping frequency, 拉比翻转频率Radial equation, 径向方程Radial wave function, 径向波函数Radiation, 辐射Radius, 半径Raising operator, 上升算符Rayleigh's formula, 瑞利公式Realist position, 实在论立场Recursion formula, 递推公式Reduced mass, 约化质量Reflected wave, 反射波Reflection coefficient, 反射系数Relativistic correction, 相对论修正Rigid rotor, 刚性转子Rodrigues formula, 罗德里格斯公式Rotating wave approximation, 旋转波近似Rutherford scattering, 卢瑟福散射Rydberg constant, 里德堡常数Rydberg formula, 里德堡公式SScalar potential, 标势Scattering, 散射Scattering amplitude, 散射幅Scattering angle, 散射角Scattering matrix, 散射矩阵Scattering state, 散射态Schrodinger equation, 薛定谔方程Schrodinger picture, 薛定谔绘景Schwarz inequality, 施瓦兹不等式Screening, 屏蔽Second-order correction, 二级修正Selection rules, 选择定则Semiconductor, 半导体Separable solutions, 分离变量解Separation of variables, 变量分离Shell, 壳Simple harmonic oscillator, 简谐振子Simultaneous diagonalization, 同时对角化Singlet state, 单态Slater determinant, 斯拉特行列式Soft-sphere scattering, 软球散射Solenoid, 螺线管Solids, 固体Spectral decomposition, 谱分解Spectrum, 谱Spherical Bessel functions, 球贝塞尔函数Spherical coordinates, 球坐标Spherical Hankel functions, 球汉克尔函数Spherical harmonics, 球谐函数Spherical Neumann functions, 球纽曼函数Spin, 自旋Spin matrices, 自旋矩阵Spin-orbit coupling, 自旋-轨道耦合Spin-orbit interaction, 自旋-轨道相互作用Spinor, 旋量Spin-spin coupling, 自旋-自旋耦合Spontaneous emission, 自发辐射Square-integrable function, 平方可积函数Square well, 方势阱Standard deviation, 标准偏差Stark effect, 斯塔克效应Stationary state, 定态Statistical interpretation, 统计诠释Statistical mechanics, 统计力学Stefan-Boltzmann law, 斯特番-玻尔兹曼定律Step function, 阶跃函数Stem-Gerlach experiment, 斯特恩-盖拉赫实验Stimulated emission, 受激辐射Stirling's approximation, 斯特林近似Superconductor, 超导体Symmetrization, 对称化Symmetry, 对称TTaylor series, 泰勒级数Temperature, 温度Tetragonal symmetry, 正方对称Thermal equilibrium, 热平衡Thomas precession, 托马斯进动Time-dependent perturbation theory, 含时微扰论Time-dependent Schrodinger equation, 含时薛定谔方程Time-independent perturbation theory, 定态微扰论Time-independent Schrodinger equation, 定态薛定谔方程Total cross-section, 总截面Transfer matrix, 转移矩阵Transformation, 变换Transition, 跃迁;Transition probability, 跃迁几率Transition rate, 跃迁速率Translation,平移Transmission coefficient, 透射系数Transmitted wave, 透射波Trial wave function, 试探波函数Triplet state, 三重态Tunneling, 隧穿Turning points, 回转点Two-fold degeneracy , 二重简并Two-level systems, 二能级体系UUncertainty principle, 不确定性关系Unstable particles, 不稳定粒子VValence electron, 价电子Van der Waals interaction, 范德瓦尔斯相互作用Variables, 变量Variance, 方差Variational principle, 变分原理Vector, 矢量Vector potential, 矢势Velocity, 速度Vertex factor, 顶角因子Virial theorem, 维里定理WWave function, 波函数Wavelength, 波长Wave number, 波数Wave packet, 波包Wave vector, 波矢White dwarf, 白矮星Wien's displacement law, 维恩位移定律YYukawa potential, 汤川势ZZeeman effect, 塞曼效应。
三环吲哚羟乙基胺衍生物和它们在治疗阿尔茨海默病中的用途[发明专利]
专利名称:三环吲哚羟乙基胺衍生物和它们在治疗阿尔茨海默病中的用途
专利类型:发明专利
发明人:萨莉·雷德肖,伊曼纽尔·H·德蒙特,达里尔·S·沃尔特,戴维·R·维西
申请号:CN200480041643.5
申请日:20041209
公开号:CN1914214A
公开日:
20070214
专利内容由知识产权出版社提供
摘要:本发明涉及具有Asp2(β-分泌酶、BACE1或Memapsin)抑制活性的式(I)的新的羟乙基胺化合物、它们的制备方法、包含这些化合物的组合物以及它们在治疗以升高的β-淀粉样蛋白水平或β-淀粉样蛋白沉积物为特征的疾病尤其是阿尔茨海默病中的用途。
在式(I)中,特别是A-B表示-NR -SO-或-NR-CO-;R表示氢、C烷基、C链烯基、C炔基、C环烷基、-C烷基芳基、-C烷基-杂芳基、-C烷基-杂环基、-C环烷基-芳基或-C环烷基-杂芳基;-W-表示-CH-、-(CH)-、-(CH)-、-C(H)=C(H)-或-CH-C(H)=C(H)-;X-Y-Z表示-C=CR-NR。
申请人:葛兰素集团有限公司
地址:英国米德尔塞克斯
国籍:GB
代理机构:北京市柳沈律师事务所
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原子核物理专业词汇中英文对照表
原子核物理专业词汇中英文对照表absorption cross-section 吸收截activity radioactivity 放射性活度activity 活度adiabatic approximation 浸渐近似allowed transition 容许跃迁angular correlation 关联angular distribution 分布angular-momentum conservation 动量守恒anisotropy 各项异性度annihilation radiation 湮没辐射anomalous magnetic moment 反常极矩anti neutrino 反中微antiparticle 反粒artificial radioactivity 放射性atomic mass unit 原质量单位atomic mass 原质量atomic nucleus 原核Auger electron 俄歇电bag model 袋模型baryon number 重数baryon 重binary fission 分裂变binging energy 结合能black hole 黑洞bombarding particle 轰击粒bottom quark 底夸克branching ration 分bremsstrahlung 轫致辐射cascade radiation 级联辐射cascade transition 级联跃迁centrifugal barrier 离势垒chain reaction 链式反应characteristic X-ray 特征X 射线Cherenkov counter 切连科夫计数器collective model 集体模型collective rotation 集体转动collective vibration 集体振动color charge 荷complete fusion reaction 全熔合反应complex potential 复势compound-nucleus decay 复合核衰变compound-nucleus model 复合核模型compound nucleus 复合核Compton effect康普顿效应Compton electron 康普顿电Compton scattering 康普顿苜攵射conservation law 守恒定律controlled thermonuclear fusion 受控热核聚变cosmic ray 宇宙射线Coulomb barrier 库仑势垒Coulomb energy 库伦能Coulomb excitation 库仑激发CPT theorem CPT 定理critical angular momentum 口缶界动量critical distance 临界距离critical mass临界质量critical volume 临界体积damped oscillations 阻尼震荡damped vibration 阻尼震荡damped wave 阻尼波damper减震器damping factor 衰减系数damping 衰减的damp proof防潮的damp 湿danger coefficient 危险系数danger dose危险剂量danger range危险距离danger signal危险信号data acquisition and processing system 数据获得和处理系统data base数据库data communication 数据通信data processing 数据处理data数据dating测定年代daughter atom 体原daughter element 体元素daughter nuclear 核daughter nucleus 体核daughter nuclide 体核素daughter蜕变产物dd reaction dd 反应deactivation 去活化dead band不灵敏区dead time correction 死时间校正dead time失灵时间deaerate 除deaeration 除deaerator除器空分离器deaquation 脱debris activity 碎放射性debris石卒de broglie equation 德布罗意程de broglie frequency 德布罗意频率de broglie relation 德布罗意程de broglie wavelength 德布罗意波长de broglie wave德布罗意波debye radius德拜半径debye temperature 德拜温度decade counter tube 进计数管decade counting circuit 进制计数电路decade counting tube 进管decade scaler 进位定标器decagram 克decalescence相变吸热decalescent point金属突然吸热温度decarburization 脱碳decascaler 进制定标器decatron 进计数管decay chain 衰变链decay coefficient 衰变常数decay constant 衰变常数decay constant 衰变常量decay energy 衰变能decay factor 衰变常数decay fraction 衰变分decay heat removal system 衰变热去除系统decay heat 衰变热decay kinematics 衰变运动学decay out 完全衰变decay period冷却周期decay power衰减功率decay rate衰变速度decay scheme 衰变纲图decay series 放射系decay storage衰变贮存decay table 衰变表decay time衰变时间decay 衰减decelerate 减速deceleration 减速decigram 分克decimeter wave 分波decommissioning 退役decompose 分解decomposition temperature 分解温度decomposition 化学分解decontaminability 可去污性decontamination area 去污区decontamination factor 去污因decontamination index 去污指数decontamination 净化decoupled band 分离带decoupling去耦解开decrease 衰减decrement减少率deep dose equivalent index 深部剂量当量指标deep inelastic reaction 深度弹性反应deep irradiation 深部辐照deep therapy 深部疗de excitation 去激发de exemption 去免除defectoscope 探伤仪defect缺陷definition 分辨deflecting coil 偏转线圈deflector偏转装置deformation energy 变形能deformation of irradiated graphite 辐照过墨变形deformation parameter 形变参量deformation 变形deformed nucleus 变形核deformed region 变形区域deform 变形degassing 脱degas 除degeneracy 简并degenerate configuration 退化位形degenerate gas 简并体degenerate level 简并能级degenerate state 简并态degeneration 简并degradation of energy 能量苜攵逸degradation 软化degraded spectrum 软化谱degree of acidity 酸度degree of burn up 燃耗度degree of purity 纯度dehumidify 减湿dehydrating agent 脱剂dehydration 脱deionization rate 消电离率deionization time 消电离时间deionization 消电离delay circuit延迟电路delayed alpha particles 缓发粒delayed neutron 缓发中delayed proton 缓发质deliquescence 潮解deliquescent 潮解的demagnetization 去磁denitration 脱硝density gradient instability 密度梯度不稳定性density of electrons 电密度deoxidation 脱氧deoxidization 脱氧departure from nucleate boiling ratio 偏离泡核沸腾departure from nucleate boiling 偏离泡核沸腾depleted fuel贫化燃料deposit dose地沉降物剂量deposited activity沉积的放射性deposition 沉积deposit 沉淀depression 减压depressurization accident 失压事故depressurizing system 降压系统desalinization 脱盐desalting 脱盐descendant 后代desorption 解吸detailed balance principle 细致平衡原理detection of radiation 辐射线的探测detonation 爆炸deuteride氘化物deuterium alpha reaction 氘反应deuterium 重氢deuton氘核deviation 偏差dew point 露点dextro rotatory 右旋的diagnostic radiology 诊断放射学diagnostics 诊断diagram 线图diamagnetism 反磁性diameter 直径diamond稳定区;金刚diaphragm 薄膜diatomic gas 双原体diatomic molecule 原分dielectric 电介质differential control rod worth 控制棒微分价值differential cross section 微分截diffraction spectrometer 衍射谱仪diffraction spectrum 衍射光谱diffraction 衍射diffuse扩苜攵diffusion stack 务马堆diffusion theory扩苜攵理论diffusion time扩苜攵时间diffusion扩苜攵dilution 稀释dipole偶极dirac equation 狄拉克程direction 向discharge 放电discrete离苜攵的disintegrate 蜕衰disintegration 蜕变dislocation 位错disorder 序dispersion 分苜攵displacement current 位移电流displace位移;代替dissociation 离解dissolution 溶解distillation 蒸馏distortion 畸变divergence 发苜攵domain磁畴Dopper effect多普勒效应dose albedo剂量反照率dose build up factor 剂量积累因dose equivalent 剂量当量dose rate 剂量率dose 剂量down quark 下夸克dry out 烧duality 重性duct 管dysprosium 镝endothermic reaction 吸能反应energy conservation 能量守恒even-even nucleus 偶偶核exchange force 交换力excited state 激发态exothermic reaction 放能反应exposure 照射量fatigue 疲劳feedback 反馈fermi age费年龄fermion 费fermium 镶fermi 费Feynman diagram 费恩曼图field theory 场论fine structure 精细结构fissile分裂的fissionable 分裂的fission barrier 裂变势垒fission fragment 裂变碎fission product yield 裂变产额fission product 裂变产物flattening of neutron flux 中通量展平fluorescent x rays 荧光x 射线fluorine 氟flux通量forbidden band 禁带force 力francium 钫free electron 由电free energy 由能frenkel defect弗兰克尔缺陷frictional force 摩擦力fuel assembly grid燃料集合体栅格fuel assembly核燃料组件fuel cell燃料电池fuel depletion 燃料贫化fuel reprocessing 燃料后处理function 函数fusion核聚变galaxy 星系Gamow-Teller interaction G-T 相互作gauge boson 规范波gauge field theory 规范场论Geiger-MCiller counter 盖-勒计数器Geiger-Nuttal law 盖-努塔尔定律geometrical cross-section 何截germanium detector 锗探测器giant resonance 巨共振gluon 胶grid ionization chamber 屏栅电离室hadron 强heavy ion 重离helicity 螺旋性Higgs particle 希格斯粒Hubble constant 哈勃常量Hubble law 哈勃定理incoming channel 射道incoming particle 身寸粒independent-particle model 独立粒模型induced fission 诱发裂变inelastic collision 弹性碰撞inelastic scattering 弹性苜攵射inertial confinement 惯性约束internal conversion 内转换intrinsic electric quadrupole moment 内禀电四极矩intrinsic parity 内禀宇称island of isomerism 同核异能素岛island of stability 稳定岛isobaric spin,isospin 同位旋isobar同量异位素isomer 同核异能素isospin analog state 同位旋相似态isospin multiplet 同位旋多重态isotone同中异位素isotope同位素j j coupling j j 耦合joule heat 焦热jump function阶跃函数junction particle detector 结型粒探测器kerma rate 释动能率kerma柯玛kernel approximation method 核近似法kernel function 核函数kernel 核kerr cell克尔盒kerr effect克尔效应kevatron千电伏级加速器key measurement point 关键测量点k factor增殖系数kinetic theory of gases 体运动论kirchhoff's radiation law基尔霍夫辐射定律klein gordon equation 克莱因登程klein nishina formula克莱因仁科公式knight shift奈特移位knocking out 原位移knock on atom 撞出原knock on 撞击撞出k shell k 层Kurie plot 库里厄图labeled 踪的labile不稳定的lag延迟laminar flow 层流lande g factor 朗德因lanthanides 镧系lanthanum 镧laplace's operator拉普拉斯算符laplacian拉普拉斯算符larmor frequency 回旋频率laser cooling激光冷却laser enrichment process 激攵光浓缩法laser isotope separation method 激光同位素分离法laser pulse激光脉冲laser 激光latent energy 潜能lattice cell 栅元lattice constant 晶格常数lattice defect 点阵缺陷lattice energy 晶格能量lattice parameter 晶格常数lattice 格laue photograph 劳厄照相lawrencium 镑Lawson criterion 劳森判据lead 铅lepton 轻level能级liberation 游离limit极限liquid metal液态金属liquid model液体模型liquid phase 液相lithium 锂lorentz force 洛伦兹力lorentz gas洛伦兹体lorentz invariance洛伦兹不变性low activity waste 低放废物lower limit 下限lutetium 错macroscopic cross section 宏观截macroscopic state 宏观态magic number 幻数magnesium 镁magnetic dipole 磁偶极magnetic field 磁场magnetic resonance 磁共振magnetism 磁manganese 锦many body forces 多体力many body problem 多体问题mass abundance 质量丰度mass energy conversion formula 质能换算公式mass excess 质量过剩mass range质量射程mass spectrometer 质谱仪maximum 最值maxwell boltzmann distribution 克斯韦分布函数mean collision time平均碰撞时间mean field 平均场mean value 平均值mean平均melting point 熔点membrane 薄膜memory存储mendeleev's law门捷列夫周期律mendelevium 钔]mercury 汞meson exchange theory 介交换理论meson field theory 介场理论meson 介meson 介metamorphose 变形methane 甲烷methanol 甲醇methyl alcohol 甲醇migration 移动mobility迁移率moderate 减速moderation 减速modulus of elasticity 弹性模数modulus of rigidity 刚性模数modulus of rupture 断裂模数modulus of torsion 扭转模数modulus 刚性模数moisture 湿molar fraction 克分分数molecular mass 分质量molecular orbital 分轨函数molten salt 熔盐molybdenum 车目monte carlo method 蒙特卡罗法neodymium 钕neon 氖neptunium 键neutrino 中微neutron flux 中通量neutronics中物理学neutron中nickel 银niobium 铌nitrogen 氮nobelium 锌nominal value 公称值nuclear fission 核裂变nuclear fission 核裂变nuclear force 核力nuclear fuel 核燃料nuclear spallation 核苜攵裂nucleon 核 nucleus 核nuclide 核素nu factor 每次裂变后的中产额ood-A nucleus 奇 A 核ood-ood nucleus 奇奇核optical model 光学模型 orbital angular momentum 轨道 动量 orbital electron capture 轨道电俘 获 pair creation , pair production 对产 pairing correlation 对关联pairing energy 对能parent nucleus 核parity 宇木称 partial-wave analysis 分波分析 partial-wave cross-section 分波截particle physics 粒物理 photoelectric effect 光电效应 pick-up reaction 拾取反应polarization 极化度 potential barrier 势垒 prompt neutron 瞬发中proportional chamberproton radioactivityproton 质quark confinementquark-gluon plasmaquark model夸克模型 quark 夸克radiation damage 辐射损伤radiation dose 辐射剂量radiation protection 辐射防护radiative capture 辐射俘获 radioactive dating 放射性鉴年法 radioactive equilibrium 放射性平衡radioactive nuclide 放射性核素radioactive series 放射系radioactivity 放射性range 射程 reaction channel 反应道 reaction cross-section 反应截 正室 质放射性夸克禁闭 夸克-胶等离体reaction energy 反映能reaction product 反应产物reaction yield 反应产额recoilless resonance absorption 反冲共振吸收residual interaction 剩余相互作residual nuclease 剩余核resolution 分辨率resolving time 分辨时间resonance cross-section 共振截resonance energy 共振能量resonance state 共振态rotational energy level 转动能级saddle point 鞍点samarium poisoning 钐中毒samarium 钐scalar标量scandium 铳scattering 苜攵射scheme图解Schrodinger equation 薛定谔程scintillation detector 闪烁探测器scram control快速停堆控制scram discharge volume快速停堆排放量scram rod安全棒selenium 办西self absorption coefficient 吸收系数self absorption 吸收self adjoint matrix 共轭矩阵self adjoint operator 共轭算self adjoint 轭的semiconductor 半导体sensitivity 灵敏度series系;级数shell model 壳层模型shell structure 壳层结构shim rod补偿棒shim补偿shut off rod 安全棒silicon 硅simulation 模拟singularity 奇性slab reactor平板反应堆slow down 减速slowing down area 慢化积small angle scattering 苜攵射sodium fluoride 氟化钠sodium 钠soft component of cosmic rays 字宙射线的软成分solar cosmic ray 太阳宇宙线solar neutrino 太阳中微solar x ray太阳x射线solenoid螺旋管solid angle 立体solid phase 固相solid solution 固溶体soluble可溶的solute溶质source data 源数据source strength 源强度space group 空间君羊space lattice 空间点阵spacing 间距spallation 苜攵裂special relativity 狭义相对论special report 专题报告special theory of relativity 狭义相对论specific activity 放射性specific binding energy 结合能specific burn up 燃耗specific charge 电荷specific concentration 浓度specific 的specimen 试样spectral line 光谱线spectral series 光谱线系spectrum 谱speed速率spent nuclear material pool烧过的核材料贮存池sphere 球spherical reactor 球形反应堆spherical wave 球波spin angular momentum 旋动量spin dependent force 旋相关力spin 旋splitting of energy levels 能级分裂splitting ratio 分开spontaneous decay 发衰变spot 斑sputtering 飞溅square bracket 括弧stable equilibrium 稳定平衡stainless steel 不锈钢standing wave 驻波stark effect斯塔克效应statistical error 统计误差statistical fluctuation 统计涨落statistical mechanics 统计力学statistical straggling 统计涨落statistical uncertainty 统计不确定性statistical weight 统计重量statistical 统计的statistic analysis 统计分析statistics 统计学statistics 统计性质steam generator 蒸汽发器steam void 汽steam 蒸汽stefan boltzmann ] constant斯蒂芬玻尔兹曼常数stern gerlach experiment 斯登盖拉赫实验stochastic process 随机过程stoichiometry 化学计算法stokes'law斯特克斯定律stopping power 阻本领strangeness number 奇异数strangeness 奇异性strange particle 奇异粒strange particle 奇异粒strange quark 奇异夸克strength function 强度函数strontium 锶structure factor 结构因subcritical assembly 亚临界装置subcritical亚临界的subgroup 君羊sublimation 升化subprogram 程序subroutine 程序subscript 下标subtraction 减法sulfur 硫superconductivity 超导性superconductor 超导体supercooled 过冷的superheated vapor 过热蒸汽superheated 过热的superlattice 超晶格superposition principle 迭加原理superposition 重叠supersaturation 过饱和superscript 上标surface tension 表张力susceptibility 磁化率suspension colloid 悬浮胶体swelling 膨胀switch开关symmetry对称性synchrotron radiation 同步加速辐射synthesis 合成system of atomic units 原单位制threshold energy 阈能time-of-flight 飞行时间top quark 顶夸克total cross section 总截track detector径迹探测器transfer reaction 转移反应transition probability 跃迁概率two-component neutrino theory 分量中微理论unclean separation energy 核分离能unified model综合模型unique forbidden transition 唯性禁戒跃迁up quark 上夸克uranium series 铀系vector boson 量波vibration energy level 振动能级volume energy 体积能weak interaction 弱相互作yrast line 转晕线yrast state 转晕态。
敲除炎症受体在阿尔兹海默症骨质疏松治疗中的应用[发明专利]
专利名称:敲除炎症受体在阿尔兹海默症骨质疏松治疗中的应用
专利类型:发明专利
发明人:崔舜,李芳瑜
申请号:CN202210281944.5
申请日:20220322
公开号:CN114452394A
公开日:
20220510
专利内容由知识产权出版社提供
摘要:本发明涉及阿尔兹海默症相关病症研究领域,具体公开了敲除炎症受体在阿尔兹海默症治疗中的应用。
炎症受体C3aR拮抗剂在制备防治阿尔兹海默症骨质疏松药物中的应用。
炎症受体RAGE 拮抗剂在制备防治阿尔兹海默症骨质疏松药物中的应用。
C3aR‑RAGE联合拮抗剂在制备防治阿尔兹海默症骨质疏松药物中的应用。
C3aR拮抗剂‑RAGE拮抗剂结合体在制备防治阿尔兹海默症骨质疏松药物中的应用。
C3a活化抑制剂在制备防治阿尔兹海默症骨质疏松药物中的应用。
防治阿尔兹海默症骨质疏松的药物,包括C3aR拮抗剂‑RAGE拮抗剂结合体和/或C3aR‑RAGE联合拮抗剂。
本发明通过对阿尔兹海默症骨质疏松给出了相应的治疗方案和产品,同时针对其中部分联用的药物进行了研究,发现了其治疗效果显著改善。
申请人:华中科技大学同济医学院附属协和医院
地址:430000 湖北省武汉市解放大道1277号
国籍:CN
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分析量子力学中的波粒二象性和相互作用力
分析量子力学中的波粒二象性和相互作用力下载温馨提示:该文档是我店铺精心编制而成,希望大家下载以后,能够帮助大家解决实际的问题。
文档下载后可定制随意修改,请根据实际需要进行相应的调整和使用,谢谢!本店铺为大家提供各种各样类型的实用资料,如教育随笔、日记赏析、句子摘抄、古诗大全、经典美文、话题作文、工作总结、词语解析、文案摘录、其他资料等等,如想了解不同资料格式和写法,敬请关注!Download tips: This document is carefully compiled by the editor. I hope that after you download them, they can help you solve practical problems. The document can be customized and modified after downloading, please adjust and use it according to actual needs, thank you!In addition, our shop provides you with various types of practical materials, such as educational essays, diary appreciation, sentence excerpts, ancient poems, classic articles, topic composition, work summary, word parsing, copy excerpts, other materials and so on, want to know different data formats and writing methods, please pay attention!现代物理学中,量子力学是一门极具重要性的学科,它描述了微观世界中的微粒行为。
哺乳动物雷帕霉素靶蛋白复合物1诱导体内多巴胺能神经元的神经营养因子表达
哺乳动物雷帕霉素靶蛋白复合物1诱导体内多巴胺能神经元的神经营养因子表达韩国庆北国立大学生命科学院脑科学及工程学研究所助理教授以往研究表明哺乳动物雷帕霉素靶蛋白复合物1(mTORC1)激活由腺相关病毒[hRheb(S16H)]转导有编码人的ras基因的组成型活性形式的基因在脑(hRheb)同源富含丝氨酸的突变成组氨酸,可诱导神经营养作用,保护和修复帕金森病大鼠模型受损的多巴胺神经元,但修复的机制并不清楚。
作者最新研究发现,通过病毒载体hRheb(S16H)可以极大的诱导成年多巴胺神经元体内胶质细胞源性神经营养因子和脑源性神经营养因子的表达,但此作用可被雷帕霉素,一个特定的mTORC1抑制剂显著的减弱。
除了神经营养因子的诱导,作者的研究表明,使用针对的胶质细胞源性神经营养因子和脑源性神经营养因子的中和抗体,hRheb(S16H)诱导营养因子通过在PD的MPP+处理过的大鼠模型中的协同机制起到黑质纹状体多巴胺突起的保护作用。
这些结果表明,特定的基因递送到多巴胺神经元中黑质,从而可以提高的mTORC1的激活,导致持续的生成神经营养因子,维持和保护成人大脑中黑质纹状体多巴胺系统。
此观点发表在《中国神经再生研究(英文版)》2014年23期杂志上。
Article: "Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons" by Sang Ryong Kim (School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Institute of Life Science & Biotechnology, Kyungpook National University, Daegu 702-701, Korea; Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-842, Korea)Kim SR. Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons. Neural Regen Res. 2014;9(23):2036-2037.mTORC1 as an inducer of neurotrophic factors in dopaminergic neurons Mammalian target of rapamycin complex 1 (mTOR) kinase exists in two complexes, mTOR complex 1 (mTORC1) and mTORC2, which play central roles in the integration of cell growth in response to environmental conditions, including growth factors, amino acids, energy substrates, and oxygen.The researchers from Kyungpook National University have previously reported that the activation of mTORC1 by adeno-associated virus 1 (AAV1) transduction with a gene encoding the constitutively active form of human ras homolog enriched in brain (hRheb) with a mutation of serine to histidine at position 16 [hRheb(S16H)] could induce trophic effects. This resulted in the protection and restoration of DA neurons in the 6-hydroxydopamine (6-OHDA)-treated model ofPD. In addition to the induction of neurotrophic factors, our results using neutralizing antibodies against GDNF and BDNF have shown that Rheb(S16H)-induced trophic factors contribute to the protection of nigrostriatal DA projections via a synergetic mechanism in the MPP+-treated rat model of PD (Nam et al., 2014). These results suggest that a specific gene delivery to DA neurons in the SN, which can enhance the activation of mTORC1, results in the sustained production of diverse neurotrophic factors that are involved in the maintenance and protection of the nigrostriatal DA system in the adult brain. In conclusion, hRheb(S16H) has robust trophic and protective effects on nigrostriatal DA projections in the adult brain. The sustained production of GDNF and BDNF via an mTORC1-dependent pathway contributes to neuroprotection in animal models of PD (Nam et al., 2014). Similar to these effects, naringin can induce the production of GDNF in adult DA neurons, highlighting it as a therapeutic agent against neurodegeneration through mTORC1 activation (Leem et al., 2014). Although more research is necessary to support these results and to optimize treatment methods, our observations suggest that activation of mTORC1 by specific gene delivery or treatment with specific compounds can induce the production of neurotrophic factors, such as GDNF and BDNF, in DA neurons. This may be a useful strategy to protect and maintain the nigrostriatal DA system in the adult brain.Article: "Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons" by Sang Ryong Kim (School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Institute of Life Science & Biotechnology, Kyungpook National University, Daegu 702-701, Korea; Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-842, Korea)Kim SR. Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons. Neural Regen Res. 2014;9(23):2036-2037.。
原花青素脑保护作用的研究
原花青素脑保护作用的研究张艳;刘珊丽;曹志斌;张建东;崔明【摘要】Aim To investigate the protective effect ofprocyanidin on cerebral ischemia - reperfusion injury inrats and its mechanism. Methods 80 male SD rats ( 300 ± 50 ) g were randomly divided into 5 groups: sham group, model group, and 50, 100, 200 mg ? Kg'1 procyanidin groups. The model of focal cerebral ischemia-reperfusion in rats was established with modified sutured-occluded method. Procyanidin groups were injected with procyanidin at the matched concentration at 30 minutes before ischemia. And the rest rats were injected with saline. All rats were given one more time in 2 hours after ischemia. The expression of ASICla in brain slices was tested with the method of immunohisto-chemistry. The activity of MPO and iNOS was meas-ured. Result Procyanidin at different dosages ( 50, 100 and 200 mg ? Kg'1 ) reduced the expression of ASICla in rat' s brain of cerebral ischemia-reperfusion and reduced the activity of MPO and iNOS in rats of focal cerebral ischemia-reperfusion injury. Conclusions Procyanidin can relieve the cerebral ischemia-reperfusion injury, and its mechanism may be partly related to the effects of its antiinflammation, antioxidation and inhibition of the expression of ASICla.%目的探讨原花青素对大鼠脑缺血/再灌注损伤的保护作用及机制.方法 80只♂大鼠随机分成5组,假手术组、模型组和原花青素低、中、高剂量(50、100、200 mg·kg-1)组.采用改良的线栓法制备大鼠局灶性脑缺血(2 h)/再灌注(24 h)损伤模型,原花青素各组于缺血前30 min和缺血后2 h腹腔注射原花青素溶液,假手术组和模型组给与等体积的NS.再灌注24 h后,测定脑片中ASIC1a的表达及MPO和iNOS活性.结果原花青素能降低缺血区脑组织中ASIC1a的表达,并且可降低脑组织中MPO和iNOS的活性.结论原花青素对大鼠脑缺血/再灌注损伤有保护作用,其机制可能与抗炎、抗氧化以及抑制ASIC1a的表达有关.【期刊名称】《中国药理学通报》【年(卷),期】2011(027)011【总页数】4页(P1600-1603)【关键词】原花青素;脑缺血/再灌注;脑保护;髓过氧化物酶;一氧化氮合酶;酸敏感离子通道【作者】张艳;刘珊丽;曹志斌;张建东;崔明【作者单位】郑州大学,基础医学院药理学教研室,河南,郑州,450052;郑州大学,基础医学院药理学教研室,河南,郑州,450052;郑州大学,基础医学院药理学教研室,河南,郑州,450052;郑州大学,基础医学院药理学教研室,河南,郑州,450052;郑州大学,基础医学院药理学教研室,河南,郑州,450052;郑州大学,第五附属医院,河南,郑州,450052【正文语种】中文【中图分类】R-332;R284.1;R322.81;R329.24;R743.310.22脑缺血是临床上常见的急性脑血管疾病,具有高致残率和高致死率。
白藜芦醇抑制大鼠下丘脑脑片室旁核神经元放电(英文)
白藜芦醇抑制大鼠下丘脑脑片室旁核神经元放电(英文)王茹;肖琳;马慧娟;张丽华;何瑞荣;武宇明【期刊名称】《生理学报》【年(卷),期】2008(60)2【摘要】本文旨在研究白藜芦醇(resveratrol)对下丘脑脑片室旁核神经元放电的影响。
应用玻璃微电极细胞外记录单位放电技术,在下丘脑脑片上观察白藜芦醇对静息状态下室旁核神经元放电的影响。
结果如下:(1)在29张下丘脑脑片室旁核神经元放电单位给予白藜芦醇(0.05,0.5,5.0μmol/L)2min,有28张脑片(96.6%)放电频率显著降低,且呈剂量依赖性;(2)预先用0.2mmol/L的L-glutamate灌流8张下丘脑脑片,8张脑片(100%)放电频率显著增加,表现为癫痫样放电,该放电可被白藜芦醇(5.0μmol/L)灌流2min抑制;(3)预先用L型钙通道开放剂BayK8644(0.1μmol/L)灌流8张下丘脑脑片,8张脑片(100%)放电频率显著增加,该放电可被白藜芦醇(5.0μmol/L)灌流2min抑制;(4)用一氧化氮合酶抑制剂Nω-nitro-L-arginine methyl ester(L-NAME)50μmol/L灌流8张下丘脑脑片,7张脑片(87.5%)放电频率显著增加,该放电可被白藜芦醇(5.0μmol/L)灌流2min抑制。
以上结果提示,白藜芦醇抑制下丘脑室旁核神经元自发放电,可能通过降低心血管中枢的活动性而产生中枢保护作用。
这种抑制作用可能与白藜芦醇抑制L型钙通道、减少钙内流有关,与NO释放无关。
【总页数】5页(P279-283)【关键词】下丘脑室旁核;白藜芦醇;钙电流【作者】王茹;肖琳;马慧娟;张丽华;何瑞荣;武宇明【作者单位】河北医科大学基础医学研究所生理室【正文语种】中文【中图分类】Q426【相关文献】1.染料木黄酮对大鼠下丘脑脑片室旁核神经元放电的影响 [J], 王茹;武宇明;肖琳;王昕;何瑞荣2.银杏内酯B对大鼠下丘脑室旁核神经元自发放电的影响(英文) [J], 林悦;王茹;王昕;何瑞荣;武宇明3.尾加压素Ⅱ对大鼠下丘脑室旁核神经元放电的影响(英文) [J], 武宇明;王茹;何瑞荣4.血管紧张素Ⅱ、心房钠尿肽Ⅲ和血管升压素对大鼠脑片室旁核神经元放电活动的影响 [J], 杨丽明;王志安;何瑞荣5.白细胞介素-1β对大鼠离体室旁核脑片神经元放电活动的影响及其机制 [J], 李莹;吴思瑶因版权原因,仅展示原文概要,查看原文内容请购买。
姜黄素对大鼠慢性脑缺血诱发脑损伤的保护作用及分子机制研究
姜黄素对大鼠慢性脑缺血诱发脑损伤的保护作用及分子机制研究杨柳;张敏;贺曦;朱洁;王进平;孟涛【摘要】目的:观察姜黄脑素对缺血后海马组织中细胞色素C以及caspase-3蛋白的表达情况,探讨姜黄素发挥其神经保护作用的机制。
方法将50只SD大鼠随机分为假手术组(Sham)、正常对照组、缺血后二甲基亚砜(DMSO)干预对照组、姜黄素高剂量组(100 mg/kg)和姜黄素低剂量组(50 mg/kg)。
所有治疗组于术后24 h开始以姜黄素每日腹腔注射,连续28 d。
给药结束后,对各组进行Morris水迷宫试验测试大鼠空间学习和记忆能力,然后处死大鼠,用HE染色和尼氏染色观察海马组织的病理形态变化,Western-Blot法检测海马组织中细胞色素C和capase-3蛋白的表达情况。
结果与各对照组比较,姜黄素明显增强了慢性脑缺血大鼠的空间学习和记忆能力,而且明显减轻了神经细胞的凋亡。
Western-Blot法检测到姜黄素使海马组织中细胞色素C和caspase-3蛋白表达水平明显降低( P<0.05)。
结论姜黄素对慢性大脑缺血诱发脑损伤有明显的神经保护作用,其机制可能是通过细胞色素C途径抑制caspase-3蛋白的表达而发挥作用。
%Objective To observe the effects of curcumin on the expression of cytochrome C and caspase-3 protein in the hippocampus tissue after ischemia,and to explore the potential mechanism for curcumin playing its neuroprotection role. Methods 50 Sprague-Daw-ley rats were randomly divided into the sham-operation group ( Sham ) ,normal controlgroup,bilateral common carotid occlusion(2VO)+dimethylsulfoxide(DMSO)intervention control group,curcumin high dose group(100 mg/kg)and curcumin low dose group(50 mg/kg). All treatment groupswere intraperitoneally injected by curcumin with in 24 h after operation for consecutive 28 d. Each group was per-formed the Morris water maze test for detecting the spatial learning and memory ability after medication. Then the rats were killed and the pathological morphological changes of hippocampus were observed by the hematoxylin and eosin(HE) staining and Nissl stain-ing. Western-Blot was used to detect the expression of cytochrome C and caspase-3 in the hippocampus tissue. Results Compared to the various control groups,curcumin significantly enhanced the spatial learning and memory ability in the chronic ischemic rats and ob-viously alleviated the apoptosis of nerve cells. The Western-Blot detection showed that curcumin significantly decreased the expression levels of cytochrome C and caspase-3 protein in the hippocampus tissue( P < 0. 05). Conclusion Curcumin has obviously neuropro-tective effect on the brain injury induced by chronic cerebral ischemia,its mechanism could be that curcumin might inhibit caspase-3 protein expression through cytochrome C pathway.【期刊名称】《中国药业》【年(卷),期】2015(000)004【总页数】4页(P31-33,34)【关键词】姜黄素;慢性脑缺血;细胞色素C;细胞凋亡【作者】杨柳;张敏;贺曦;朱洁;王进平;孟涛【作者单位】重庆市急救医疗中心神经内科,重庆 400014;重庆市急救医疗中心神经内科,重庆 400014;重庆市急救医疗中心神经内科,重庆 400014;重庆市急救医疗中心神经内科,重庆 400014;重庆市急救医疗中心神经内科,重庆 400014;重庆市急救医疗中心神经内科,重庆 400014【正文语种】中文【中图分类】R285.5;R282.71血管性痴呆(VD)是老年人群常见的痴呆类型之一,是一类与脑血管因素有关的痴呆,通常以各种脑血管疾病导致脑组织损伤引起的认知功能障碍为临床特征。
双氢青蒿素通过调节TGF-β
doi:10.3969/j.issn.1000-484X.2023.09.011双氢青蒿素通过调节TGF-β/Smad通路改善小鼠接触性皮炎①孙鸣远②金权鑫③张馨元张琪李芳芳金桂花(延边大学医学院免疫学与病原生物学教研室,延吉 133002)中图分类号R284.2 文献标志码 A 文章编号1000-484X(2023)09-1852-06[摘要]目的:探讨双氢青蒿素(DHA)对小鼠接触性皮炎(CHS)的抑制作用及机制。
方法:0.5%2,4-二硝基氟苯(DNFB)涂抹小鼠腹部连续2 d致敏,5 d后用0.25%DNFB涂抹左耳发敏,右耳涂抹丙酮和橄榄油混合液作为对照,于致敏前2 d灌胃给予DHA处理。
HE染色观察小鼠皮肤组织病理学变化,免疫组化染色观察小鼠耳部皮肤CD4+T、CD8+T细胞浸润情况,测定脾脏指数。
ELISA检测血清IL-6、IFN-γ、IL-10、TGF-β和单核细胞趋化蛋白(MCP)-1变化,Western blot检测皮肤Smad2和Smad3磷酸化水平,流式细胞术检测皮肤和脾脏免疫细胞浸润情况。
结果:DHA可显著改善CHS小鼠耳朵肿胀、皮肤红斑及脾脏指数(P<0.05)。
组织病理学结果显示,DHA处理可明显抑制CHS小鼠皮肤增厚和炎症细胞浸润。
流式细胞术结果显示,DHA处理后皮肤和脾脏中浸润的CD4+T细胞、CD8+T细胞、树突状细胞和巨噬细胞显著减少(P<0.05)。
ELISA结果显示,相对于模型组,DHA处理组血清IL-6、IFN-γ、TGF-β和MCP-1水平明显降低(P<0.05)。
Western blot结果表明DHA处理显著抑制皮肤Smad2和Smad3磷酸化水平(P<0.05)。
结论:DHA通过减少免疫细胞浸润和调节TGF-β/Smad信号传导抑制CHS,为治疗CHS提供了新的药物选择和实验依据。
[关键词]接触性皮炎;双氢青蒿素;TGF-β;Smad2/3Dihydroartemisinin ameliorates contact hypersensitivity in mice by regulating TGF-β/Smad signaling pathwaySUN Mingyuan, JIN Quanxin, ZHANG Xinyuan, ZHANG Qi, LI Fangfang, JIN Guihua. Department of Immunology and Pathogenic Biology, Yanbian University Medical College, Yanji 133002, China[Abstract]Objective:To investigate inhibition of dihydroartemisinin (DHA) on contact hypersensitivity (CHS) in mice and its mechanisms. Methods:Mice were sensitized with 0.5%2,4-dinitrofluorobenzene (DNFB)on shaved abdominal flank skin for 2 consecutive days, and CHS was elicited by 0.25%DNFB on left ear 5 days later. Right ear was treated with acetone/olive-oil alone as control. Mice were given DHA orally 2 days before sensitization. Skin histopathological changes were observed by HE staining,infiltra‐tions of CD4+T and CD8+T cells in ear skin were observed by immunohistochemical staining, and spleen index was detected. Serum IL-6,IFN-γ, IL-10, TGF-β and monocyte chemotactic protein (MCP)-1 changes were detected by ELISA, skin Smad2 and Smad3 phos‐phorylation levels were detected by Western blot,and skin and spleen immune cells infiltration were detected by flow cytometry. Results:DHA significantly improved ear swelling, skin erythema and spleen index of CHS mice (P<0.05). Histopathological analysis revealed that degree of edema and cellular infiltration were markedly decreased in DHA-treated CHS mice. Flow cytometry results show that DHA treatment significantly decreased CD4+T cells, CD8+T cells, dendritic cells and macrophages infiltration in ear skin and spleen (P<0.05). ELISA results showed that DHA treatment also diminished serum levels of IL-6, IFN-γ, TGF-β and MCP-1 compared with model group (P<0.05). Western blot showed that Smad2 and Smad3 phosphorylation were normalized by DHA treat‐ment (P<0.05). Conclusion:DHA suppresses CHS by reducing infiltration of immune cells and regulating TGF-β/Smad signaling pathway, which provides a new drug selection and experimental basis for CHS treatment.[Key words]Contact hypersensitivity;Dihydroartemisinin;TGF-β;Smad2/3①本文为国家自然科学基金项目(81960305)。
阿尔茨海默病的纳米疗法研究进展
固体脂质 载体
胡椒碱固体脂质纳米粒[33] 槲皮素固体脂质纳米粒[34]
靶向性高,药物物理稳定 性强,药物释放性良好
脂质/ 脂蛋白 纳米颗粒
ApoE3-rHDL[35]
乳铁蛋白-姜黄素低密度脂蛋白 纳米粒[36]
载药能力强,稳定性高, 药物不良反应低
金属基 载体
氧化铈纳米颗粒[40] TPP-Ceria NPs[41]
大量的纳米载体和 NPs 前体药物在动物模型中的细胞 毒性可以忽略不计,纳米释药系统还可以非侵入性地将药物 递送至大脑,通过靶向给药可增强治疗 AD 的各种药物、生 物活性剂的生物利用度或生物有效性,NMs 在穿过 BBB 治
* 基金项目
作者简介 **通讯作者
收稿日期
国家重点研发计划渊2016YFC1306300冤曰国家重点研发计 划渊2018YFA0108503冤 王晓珍袁女袁研究实习员 E-mail: wxz.6016@ 王蓉袁女袁博士生导师 E-mail: wangrong@ 2020-09-30 修回日期 2021-01-11
Kulkarni PV 等[16]开发了一种基于 2-氰基丙烯酸正丁酯 的脑靶向纳米多聚体系统,包载了放射性标记的淀粉样脂肪 酸药物 125I-氯碘喹啉(CQ,5-氯-7-碘-8-羟基喹啉),用于 AD 的早期诊断,在小鼠模型中,负载的 NPs 可有效地穿过
表 1 不同类型纳米药物及其特点
NMs 类型
成螺旋片段,产生神经纤维缠结,最终导致神经元死亡。目前 发现的 Tau 蛋白磷酸化位点至少有 45 个,其中主要发生在 丝氨酸残基和苏氨酸残基的羟基上。Tau 蛋白的磷酸化受一 系列激酶的调节,包括蛋白激酶 A、糖原合成酶激酶 3茁、酪 氨酸激酶和细胞周期蛋白依赖激酶 5 等[8]。研究表明,相比 茁-淀粉样蛋白的异常沉积,Tau 蛋白的异常磷酸化所致的聚 集同 AD 的相关性更高。 1.3 小胶质细胞
作为PDE4抑制剂的[1,7]二氮杂萘[发明专利]
专利名称:作为PDE4抑制剂的[1,7]二氮杂萘
专利类型:发明专利
发明人:A·德诺姆,T·H·凯勒,C·麦卡锡,N·J·普雷斯,R·J·泰勒申请号:CN200380106300.8
申请日:20031215
公开号:CN1726215A
公开日:
20060125
专利内容由知识产权出版社提供
摘要:本发明公开了游离或盐形式的式I化合物,其中R、R和R具有说明书中指定的含义,这些化合物可用于治疗4型磷酸二酯酶介导的疾病或减量调节或抑制TNF-α释放,特别是阻塞性或炎性气道疾病。
本发明还描述了含有所述化合物的药物组合物和制备所述化合物的方法。
申请人:诺瓦提斯公司
地址:瑞士巴塞尔
国籍:CH
代理机构:北京市中咨律师事务所
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抗阿尔兹海默症灯盏乙素苷元衍生物设计、合成及活性研究
背景介绍阿尔兹海默症(AD)是一种渐行性神经退行性疾病,是导致痴呆的主要原因。
灯盏乙素及其活性代谢物灯盏乙素苷元(Scutellarein)具有广泛的药理活性,包括抗氧化、神经保护、金属螯合和抗炎特性,以及改善Aβ诱导的损伤等,表明灯盏乙素可能成为治疗A D的有利药物。
基于A D这种神经退行性疾病表现出复杂的发病机制表明,人们的注意力正转向探索多靶点定向配体策略(MTDLs),即单个药物分子可以同时与疾病病理相关的多个靶点结合并调节。
本文亮点1、根据多靶点定向配体策略,以灯盏乙素苷元为骨架,通过不同的连接体,连接N,N-双取代氨基甲酸酯片段和炔丙胺,N-甲基炔丙胺片段,设计并合成抗AD灯盏乙素苷元衍生物;2、基于AD的胆碱酯酶假说和单胺氧化酶假说,根据Ellama法和Holt法,进行酶活性测试,2-(4-((二甲基氨基甲酰基)氧基)苯基)-5,6-二羟基-4-氧代-4H-色烯-7-基5-(甲基(丙-2-炔-1-基)氨基)-5-氧代戊酸酯对两种酶表现出较好的抑制活性;3、目标化合物可能是一个具有潜力的抗AD化合物,有待在抗氧化活性、金属离子螯合、肝微粒体代谢等抗AD活性实验中进一步研究。
内容介绍1 实验部分1.1主要仪器与试剂1.2实验步骤1.2.1灯盏乙素苷元的制备3mol/L硫酸-95%乙醇溶液的制备:①先配制95%乙醇:取950mL的无水乙醇于1000mL容量瓶中,用超纯水定容,摇匀,装入备用瓶。
②取163mL(18.4mol/L)浓硫酸,少量多次加入到盛有上述95%乙醇的大烧杯中,勤搅拌,待冷却后,转移至1000mL容量瓶,用95%乙醇定容,摇匀备用。
苷元的制备:取2.00g灯盏乙素于250mL的圆底烧瓶中,加入180mL的上述硫酸-乙醇溶液,80℃回流20h,至橘红色澄清液体。
反应结束后,倒入盛有2L冰水的大烧杯中,待沉淀析出完全后,抽滤,超纯水反复洗涤滤饼至中性,用无水乙醇溶解并减压旋干,得到黄色灯盏乙素苷元粗品,产率70%,直接用于下一步反应。
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a r X i v :h e p -p h /0404103v 3 13 A u g 2004SISSA 26/2004/EP hep-ph/0404103Reactor Anti-Neutrino Oscillations and GadoliniumLoaded Super-Kamiokande DetectorSandhya Choubey 1,2and S.T.Petcov 2,1,3,41INFN,Sezione di Trieste,Trieste,Italy.2Scuola Internazionale Superiore di Studi Avanzati,I-34014Trieste,Italy.3Yukawa Institute for Theoretical Physics,Kyoto University,Kyoto 606-8502,Japan.4Institute of Nuclear Research and Nuclear Energy,Bulgarian Academy of Sciences,1784Sofia,Bulgaria.AbstractWe explore the potential of measuring the solar neutrino oscillation parameters in the proposed gadolinium loaded Super-Kamiokande (SK-Gd)detector.Gadolinium dissolved in water can detect neutrons much more efficiently than pure water.This imparts the detector the ability to observe electron type antineutrinos,transforming Super-Kamiokande into a huge reactor antineutrino detector with an event rate approximately 43times higher than that observed in KamLAND.We simulate the reactor antineutrino data expected in this high statistics detector.We use these prospective data to study the precision with whichthe solar neutrino oscillation parameters,∆m 2⊙and sin 2θ⊙,can be determined i)with the SK-Gd detector,and ii)by combining the SK-Gd data with the global data on solar neutrinooscillations.For comparison and completeness the allowed regions of ∆m 2⊙and sin 2θ⊙,expected to be obtained from the data of the solar neutrino and KamLAND experiments,are also presented.We find that the SK-Gd experiment could provide one of the most precise (if not the most precise)determination of the solar neutrino oscillation parameters ∆m 2⊙and sin 2θ⊙.11IntroductionAt present we have compelling evidences for oscillations of both solar(νe)and atmospheric(νµand¯νµ)neutrinos,driven by nonzero neutrino masses and neutrino mixing[1,2].They have been accumulated over a long period of time in the experiments with solar neutrinos[3,4,5, 6,7,8,9,10],Homestake,Kamiokande,SAGE,GALLEX/GNO,Super-Kamiokande and SNO, in the KamLAND experiment with reactor antineutrinos[11],and in the studies of thefluxes of atmospheric neutrinos by the Super-Kamiokande collaboration[12,13,14].Indications for oscillations of neutrinos have also been obtained in the K2K long base-line experiment[15].Evidences for oscillations of the solarνe,induced by nonzero neutrino masses and neutrino mixing[2],have been reportedfirst by the pioneering Davis et al.(Homestake)experiment[16,17]. They have been confirmed and reinforced later by Kamiokande,SAGE,GALLEX/GNO and Super-Kamiokande experiments.The evidences for mixing and oscillations of the solarνe have been made compelling during the last three years by the data from the SNO solar neutrino and KamLAND reactor antineutrino experiments[8,9,10,11](see also,e.g.,[18]).Under the assumption of CPT-invariance,the observed disappearance of reactor¯νe in the KamLAND experiment,in particular, confirmed the interpretation of the solar neutrino data in terms ofνe→νµ,τoscillations,induced by nonzero neutrino masses and nontrivial neutrino mixing.The KamLAND results[11]practically established the large mixing angle(LMA)MSW solution(see,e.g.,[8])as unique solution of the solar neutrino problem.The solar neutrino and KamLAND data,including the salt phase SNO results,strongly favor the low-LMA solution with[10,19,20]∆m221∼7×10−5eV2and sin2θ12∼0.3,∆m221≡∆m2⊙andθ12≡θ⊙being the neutrino mass squared difference and mixing angle driving the solar neutrino oscillations.The high-LMA solution(see,e.g.,[11]),characterized by∆m221∼1.5×10−4eV2and similar value of sin2θ12,is only allowed at99.14%C.L.by the data [19].Strong evidences for oscillations of the atmosphericνµ(¯νµ)have been obtained in the Super-Kamiokande experiment from the observed i)Zenith angle dependence of the multi-GeV and sub-GeVµ-like events[12,13],and ii)the recently reported observation of an“oscillation dip”in the L/E−dependence of the(essentially multi-GeV)µ−like atmospheric neutrino events[14]1,L and E being the distance traveled by neutrinos and the neutrino energy.As is well known,the SK atmospheric neutrino data is best described in terms of dominant two-neutrinoνµ→ντ(¯νµ→¯ντ) vacuum oscillations with[13,14]∆m2atm≡∆m231∼(2.0−3.0)×10−3eV2and maximal mixing, sin22θatm≡sin22θ23∼1.0.The observed dip is predicted due to the oscillatory dependence on L/E of theνµ→ντand¯νµ→¯ντoscillation probabilities.This beautiful result represents the first ever observation of a direct effect of the oscillatory dependence on L/E of the probability of neutrino oscillations in vacuum.Information on the third mixing angleθ13,present in the case of3-neutrino mixing which is required to describe the solar and atmospheric neutrino(and KamLAND)data in terms of neutrino oscillations,is provided essentially by the short baseline reactor antineutrino experiments CHOOZ and Palo Verde[21].Using the range of allowed values of∆m2atm found in the latest SKdata analysis[13,22],a combined3-νoscillation analysis of the solar neutrino,CHOOZ and KamLAND data gives(at99.73%C.L.)sin2θ13<0.074[19].A somewhat more stringent limit was obtained in the global analysis of all the available solar,atmospheric and reactor neutrino data,performed in[23]:sin2θ13<0.050(99.73%C.L.).Neutrinoflavor oscillations have also been claimed to have been observed in the LSND exper-iment[24].This interpretation of the LSND results is being currently tested in the MiniBOONE experiment[25].After the remarkable progress made in the last few years in establishing the existence of neu-trino oscillations,one of the main goals of the future experimental studies of neutrino mixing is to measure with high precision the parameters which drive the solar and atmospheric neutrino oscil-lations,∆m221,∆m231,sin2θ12and sin2θ23.The potential of the current and future experiments for high precision determination of the solar neutrino oscillation parameters,∆m221and sin2θ12,was studied recently in[26,27,28,29](see also[30]).The precision in the measurement of∆m221and sin2θ12,which can be reached in the Borexino and the so-called LowNu experiments,was explored in[26,27].The impact of the prospective increase in statistics of the KamLAND data on the determination of∆m221and sin2θ12was investigated in detail in[19,26,29].If the e+−spectrum measured at KamLAND is simulated at a point in the low-LMA region,the allowed3σarea in the high-LMA zone reduces in size in the case of0.41kTy of data,and disappears if the statistics is increased to1.0kTy[19].In this case∆m221will be determined with high precision.If,however, the spectrum observed in KamLAND conforms to a point in the high-LMA region,the conflicting trend of solar and KamLAND data would make the high-LMA solution reappear at90%C.L. and the determination of∆m221would remain ambiguous[19].In both cases sin2θ12cannot be determined with high precision.Actually,reaching high accuracy in the measurement of sin2θ12 (e.g.,10%error at1σ)is a rather challenging problem.It can be solved by performing a dedicated reactor¯νe experiment[26,28],or by the future solar neutrino experiments LENS and XMASS, aiming to measure the pp neutrinoflux[31,32].Recently it was proposed in[33]to dope the SK detector with Gadolinium by dissolving0.2% gadolinium trichloride in the water2.The added gadolinium would make it possible to detect the neutrons,released in the¯νe capture on protons,with a relatively high efficiency.This would allow the SK experiment,in particular,to detect the reactor antineutrinos coming from the numerous powerful nuclear reactors located in Japan,thus transforming SK into a huge reactor antineutrino detector with an event rate approximately43times higher than that observed in KamLAND. In this paper we study the prospects of measuring the solar neutrino oscillation parameters by observing the reactor antineutrino oscillations in the proposed gadolinium loaded SK(SK-Gd) experiment.Since∆m221≪∆m231and the mixing angleθ13is restricted to be relatively small, the third(heaviest)neutrino with definite mass is expected to have negligible impact on the determination of the values of the solar neutrino oscillation parameters3in the experiment of interest and we perform our study in the framework of the2ν−mixing scenario(sin2θ13=0).We begin in Section2with an overview of the currently allowed ranges of values of the solar0.20.30.4sin 2θ121.0e−055.0e−059.0e−051.3e−041.7e−04∆m 2210.20.30.40.5sin 2θ12Figure 1:The 90%,95%,99%,99.73%C.L.allowed regions in the ∆m 221−sin 2θ12plane.The left-hand and right-hand panels show the allowed regions obtained in χ2−analysis respectively of the global data from the solar neutrino experiments and of the solar neutrino and KamLAND data.neutrino oscillation parameters by the existing global solar neutrino and KamLAND data.Wepresent further the regions in the ∆m 221−sin 2θ12plane,which are expected to be allowed after tak-ing into account future higher statistics and lower systematic data from SNO and from KamLAND experiments.The SK-Gd detector is considered in Section 3,where we discuss the assumptions made to simulate the data in this proposed modification of the SK experiment,as well as the procedure used to statistically analyze the simulated data.We investigate further the potential ofthe SK-Gd experiment in reducing the uncertainties in the values of ∆m 221and sin 2θ12.In Section 4the expected results from a combined analysis of the solar neutrino data and the prospective SK-Gd simulated spectrum data are given.In Sections 3and 4we also discuss the bounds on∆m 221and sin 2θ12one would obtain if some of the reactors in Japan would be “switched off”.Section 5contains the main conclusions of our study.2Solar Neutrino Oscillation Parameters from the Solar Neutrino and KamLAND DataWe begin by reviewing the current status of determination of the solar neutrino oscillation pa-rameters.We present in Fig.1the regions in the ∆m 221−sin 2θ12plane,allowed by the global solar neutrino data (left-hand panel),and by the combined data from the KamLAND and solar4only solar 3.2-14.965%0.22−0.3725% solar+162Ty KL 5.2-9.831%0.22−0.3725%solar with future SNO3.3−11.957%0.22−0.3421% solar+1kTy KL(low-LMA) 6.5-8.010%0.23−0.3723%solar+2.6kTy KL(low-LMA)6.7−7.77%0.23−0.3622% solar with future SNO+1.3kTy KL(low-LMA)6.7−7.88%0.24−0.3417% 3yrs SK-Gd7.0-7.43%0.25−0.3719%5yrs SK-Gd7.0−7.32%0.26−0.3515% solar+3yrs SK-Gd(low-LMA)7.0−7.43%0.25−0.3415% solar+3yrs SK-Gd(high-LMA)14.5−15.43%0.24−0.3721% solar with future SNO+3yrs SK-Gd(low-LMA)7.0−7.43%0.25−0.33514% solar with future SNO+3yrs SK-Gd(high-LMA)14.5−15.43%0.24−0.3519% 3yrs SK-Gd with Kashiwazaki“down”6.8−7.66%0.23−0.4027% 7yrs SK-Gd with only Shika-2“up”7.0−7.32%0.28−0.32 6.7%0.20.30.4sin 2θ121.0e−055.0e−059.0e−051.3e−041.7e−04∆m 221/e V20.20.30.4sin 2θ120.20.30.40.5sin 2θ12Figure 2:The 90%,95%,99%,99.73%C.L.allowed regions in the ∆m 221−sin 2θ12plane.The left-panel shows the the areas obtained in a χ2analysis of the global solar neutrino data with assumed errors of 5%and 6%on the values of the CC and NC event rates respectively,measured in the SNO experiment.The right panel shows the allowed region expected if 1.3kTy KamLAND data were added to the prospective global solar neutrino data (see text for details).neutrino experiments (right-hand panel).The global solar neutrino data used in the analysis include the total event rates measured in the Homestake [3]and SAGE+GALLEX+GNO [5,6](combined)experiments,the Super-Kamiokande 44bin Zenith angle spectrum data [7],the 34bin day-night spectrum data from the D 2O phase of the SNO experiment [9]and the charged current (CC),neutral current (NC)and elastic scattering (ES)data from the salt phase of SNO [10]4.In what concerns the KamLAND results,we use the 13binned spectrum data released by the KamLAND collaboration [11]5.Figure 1was obtained using the updated standard solar model (BP2004)results on the solar neutrino fluxes and the associated errors [36].The range of allowedvalues of the parameters ∆m 221and sin 2θ12are shown in Table 1.Also shown are the %spread,which is defined as,spread =a max −a min4We refer the reader to [18,19,34]for further details of the solar neutrino data analysis.5For details of the statistical analysis procedure used for handling the KamLAND spectral data see ref.[35].6depends both on the8Bflux normalization and the solar neutrino survival probability,the NC rate is determined,in the case offlavor oscillation involving only active neutrinos,solely by the8Bflux normalization.This gives SNO the ability to determine the averageνe survival probability and hence the oscillation parameters with a relatively good precision.In particular,the combination of CC and NC rates in SNO can be effectively used to obtain stringent upper limits on the allowed values of both∆m221and sin2θ12[37,38].The upper limits on∆m221and sin2θ12follow from the fact that the ratio of the CC and NC event rates observed in SNO is significantly smaller than 0.50[10].The smaller the ratio of the CC and NC event rates observed in SNO,the smaller the maximal allowed values of both∆m221and sin2θ12[37,38].For values of∆m221and sin2θ12in the low-LMA region,the matter-enhanced transitions of8B neutrinos inside the Sun are adiabatic and the8Bνe survival probability,which affects the CC event rate observed in SNO during day-time, is given approximately by P ee≈sin2θ12.Thus,improvement in the precision with which the CC and NC rates are measured in SNO would lead to a diminishing of the maximal allowed values of∆m221and sin2θ12,provided the mean values of these two observables do not change.This is illustrated in the left-hand panel of Fig.2where we show the regions of values of∆m221and sin2θ12,which would be allowed by the global solar neutrino data if the experimental errors in the CC and NC event rates measured by SNO are reduced respectively to5%and6%6,while the mean values of the two rates coincide with those found in the salt phase of the SNO experiment [10].We note that the maximal allowed values of both∆m221and sin2θ12would be smaller,while the minimal values essentially do not change.Thus,the uncertainties in the values of∆m221and sin2θ12would be reduced with respect to the currently existing ones.Much better precision in the determination of the value of∆m221might be achieved in the KamLAND experiment.In Table1we present the range of allowed values of this parameter and the corresponding spread expected if1kTy data of KamLAND is combined with the current solar neutrino data(see refs.[30,40]for details of the KamLAND prospective data analyses).The expected precision in the determination of∆m221from KamLAND data corresponding to statistics of2.6kTy,is also shown.Since a new reactor power plant Shika-2is planned to start operating in March of2006,we have also included the contribution of theflux from this new reactor to the data collected in KamLAND after March2006.The impact of the new Shika-2reactor on the KamLAND sensitivity to∆m221and sin2θ12was studied in detail in[29].As was shown in [29],with Shika-2reactor running,the precision with which sin2θ12can be determined in the KamLAND experiment does not improve considerably,while the high-LMA-low-LMA solution ambiguity increases.In the middle(right-hand)panel of Fig.2we show the expected allowed region when we combine a higher precision global solar neutrino data,including projected SNO III results,with prospective KamLAND data,simulated at the current low-LMA(high-LMA)best-fit point.We expect KamLAND to have collected approximately1.3kTy of data by the end of2006,when theSNO experiment is foreseen to conclude.In Fig.2we present results obtained by combining the solar neutrino data,including SNO data with5%and6%total uncertainties on the measured CC and NC event rates,respectively,with simulated1.3kTy KamLAND data.We again note that the allowed range of∆m221diminishes remarkably with the incorporation of the KamLAND data simulated at the low-LMA bestfit point.With the KamLAND data simulated at the high-LMA bestfit point,the low-high LMA solution ambiguity“appears”at95%C.L.The range of allowed values of sin2θ12,however,in both cases remains practically unchanged with the inclusion of the KamLAND data.3Measurement of the Solar Neutrino Oscillation Param-eters in the SK-Gd Reactor ExperimentSuper-Kamiokande is the world’s largest running water Cerenkov detector,situated in the Kamioka mine in Japan.Next to SK in Kamioka is the KamLAND detector.KamLAND uses1kton of liquid scintillator to detect the¯νe coming from the nuclear reactors.SK receives the same reactor antineutrinoflux as KamLAND.Since SK has ultra pure water as its detector material,it cannot efficiently tag the¯νe capture on protons.In particular,the neutron released in¯νe+p→e++n has to thermalise and then get captured to releaseγ,which can be then detected and the process tagged through delayed coincidence.The capture cross-section of thermal neutron on free protons in extremely small and hence SK is unable to separate the reactor¯νe capture events from the background.However,this could change if gadolinium was mixed with the SK water,as proposed recently in ref.[33].The capture cross-section of thermal neutron on gadolinium is known to be remarkably large.In addition,neutron capture on Gd produces8MeV energy in photons making it easier for SK-Gd to detect them.Thus,SK loaded with Gadolinium could be used as a very big reactor anti-neutrino detector[33].With its22.5kton of ultra pure water,the SK detector has about1.5×1033free protons as target for the antineutrinos coming from various reactors in Japan.The KamLAND detector has only3.46×1031free target protons[11].Therefore for the same period of measurements,SK-Gd detector is expected to have about43times the statistics of the KamLAND experiment.The number of positron events in the SK-Gd detector is given by, N SK−Gd=N p dE vis dEνσ(Eν)R(E vis,Eν) i S i(Eν)0.20.30.40.50.60.70.8sin 2θ126.4e−056.6e−056.8e−057e−057.2e−057.4e−057.6e−057.8e−058e−05∆m 221Figure 3:The 90%,95%,99%,99.73%C.L.allowed regions in the ∆m 221−sin 2θ12plane from an analysis of prospective data,obtained in 3years of running of the SK-Gd detector with all the main 17reactors running (see text for details).We simulate the data expected after 3years of running of the proposed SK-Gd detector at apoint in the low-LMA region with ∆m 221=7.2×10−5eV 2and sin 2θ12=0.3;for the high-LMA solution the data is simulated in the point ∆m 221=1.5×10−4eV 2and sin 2θ12=0.37.We construct a 18bin data with a visible energy threshold of 3MeV 8and with bin width of 0.5MeV.We wish to statistically analyze this prospective data.We define a χ2function given byχ2=i,j(N data i −N theory i )(σ2ij )−1(N data j −N theory j ),(3)where N αi (α=data,theory )is the number of events in the i th bin,σ2ij is the covariant er-ror matrix containing the statistical and systematic errors and the sum is over all bins.The KamLAND experiment in their first published results of the measurement of reactor ¯νe flux have reported a systematic error of 6.48%[11].However,while KamLAND is a liquid scintillator de-tector,SK-Gd would be practically a water Cerenkov detector.Therefore the systematics of the SK-Gd experiment would be different from those of the KamLAND experiment.We would expect the SK-Gd systematics to be similar to those of the SK solar neutrino experiment,since even the energy range of the SK-Gd reactor ¯νe experiment could be approximately the same as that of the SK solar neutrino experiment.We therefore assume a 5%systematic error in our analysis [7].3456789101112E vis (MeV)00.20.40.60.8low−LMA high−LMA00.20.40.60.81r a t i o o f e v e n t s w i t h t o w i t h o u t o s c i l l a t i o n sGadzooks with 3 years datalow−LMA high−LMA2345678E vis (MeV)0.20.40.60.8low−LMA high−LMAwith 16 reactorswith 17 reactors with 16 reactorswith 17 reactors 00.20.40.60.81KamLAND with 3 KTON−YEAR datalow−LMA high−LMAFigure 4:The ratio of the numbers of the prospective e +−events at the SK-Gd and KamLAND experiments in the cases of oscillations and of absence of oscillations,with their expected 1σerrorbars.The errorbars for the SK-Gd detector correspond to 3years of data,while those for KamLAND are for a total statistics of 3kTy.The upper panels are obtained assuming that the current 16main reactors in Japan are operative.The bottom panels correspond to the case of the Shika-2reactor operating along with the current 16main reactors.The dashed (solid)lines correspond to the low-LMA (high-LMA)solution.Figure 3shows the allowed regions in the ∆m 221−sin 2θ12plane,obtained using 3years of thus simulated data in the SK-Gd experiment,when the true solution is in the low-LMA region.In obtaining this figure we have assumed that all reactors in Japan,relevant for the analysis,including the forthcoming Shika-2reactor,would be running with their full power.We note thatthe size of the allowed areas diminishes significantly in both ∆m 221and sin 2θ12compared to thecurrently allowed regions.In Table 1we show the uncertainties in ∆m 221and sin 2θ12after three years of running of SK-Gd alone.We also give the expected uncertainties if data from 5years of running of the SK-Gd detector are used in the analysis.As Fig.3shows,the spurious high-LMA solution would be completely ruled out by the SK-Gd data,if low-LMA is the true solution.We have checked that SK-Gd can rule out the “wrong”solution with about 0.4−0.5years of data.This is in sharp contrast with what we have obtained for KamLAND,where it is hard to resolve the low-LMA –high-LMA ambiguity even with 2.6kTy of data once the Shika-2reactor is switched on.To facilitate the understanding of this result we present in Fig.4the spectral distortions predicted to be observed in the SK-Gd (left panels)and in KamLAND (right panels)experiments.The upper panels show the ratio of the events (or event rates)in the cases of oscillations and of absence of oscillations,with the current main 16reactors10running,while the lower panels are for the case where the Shika-2reactor is operating along with the other16reactors.The dashed black lines are the expected spectra for the low-LMA solution, while the red solid lines are the spectra for the high-LMA solution.The errorbars correspond to the1σstatistical errors for3years of running of the SK-Gd detector and for3kTy(∼7years) of running of the KamLAND detector.The bin sizes used are0.5MeV for SK-Gd and0.425 MeV for KamLAND.The threshold for KamLAND is taken as E th vis=2.6MeV[11],while for SK-Gd we use a threshold of E th vis=3.0MeV.For the SK-Gd detector the observed spectrum extends to nearly12MeV due to the worse energy resolution of SK.Clearly,in the16reactor case the SK-Gd experiment can distinguish between the low-LMA and high-LMA spectra.The KamLAND experiment could also distinguish between the two solutions with a3kTy statistics (see also[26,29,40])9.The differences between the e+−spectra in the cases of the low-LMA and the high-LMA solutions,measured in SK-Gd and KamLAND experiments,diminish once the Shika-2reactor is switched on.The low-LMA and high-LMA solution spectra measured with the KamLAND detector would be almost overlapping,as can be seen in the lower right-hand panel. This results in the reappearance of the“wrong”high-LMA solution,as stressed in[29].Even for the SK-Gd detector,the difference between the spectra corresponding to the two solutions reduces considerably,especially in the statistically most relevant bins.However,there are still bins at intermediate energies at which the two solutions can be easily distinguished.This is why the SK-Gd experiment could still resolve the ambiguity between the low-LMA and high-LMA solutions with Shika-2reactor operating,while KamLAND cannot.The mixing angle is most precisely determined when the baseline corresponds to a minimum in the survival probability(SPMIN)in the statistically most relevant part of the positron energy spectrum[26].It was pointed out in[29]that for the low-LMA solution the baseline from the Shika-2reactor to Kamioka is such that the SPMIN for the Shika-2flux occurs at E vis∼=4MeV. The Kashiwazaki-Kariwa power plant,which is the most powerful reactor complex in the world, is at a distance of about160km from Kamioka.Hence,the most significant part of theflux of¯νe from this most important source falls at Kamioka in the region of a survival probability maximum (SPMAX).The effectiveflux at Kamioka in absence of oscillations is defined asP iΦi KL=9Let us note that using combined data from the KamLAND detector,corresponding to statistics of1kTy,and from the solar neutrino experiments,can permit to rule out the high-LMA solution[19,29].0.20.40.60.8sin 2θ126e−058e−050.00010.000120.000140.00016∆m 221Figure 5:Allowed regions in the ∆m 221−sin 2θ12plane from an analysis of prospective data fromthe SK-Gd detector collected over a period of 3years,with the Kashiwazaki-Kariwa complex switched offand all other reactors,including the Shika-2one,running.using the data collected by the SK-Gd detector after 3years of operation with Kashiwazaki reactor complex switched off,but with the Shika-2reactor working.We show the uncertainty on ∆m 221and sin 2θ12,determined with this set up,in Table 1.We note that instead of diminishing,the uncertainty in sin 2θ12increases.Even the spurious high-LMA solution reappears in this case.The predicted spectral distortions for the low-LMA and high-LMA solutions expected to be observed in SK-Gd and KamLAND,when the Kashiwazaki-Kariwa power plant does not operate,while the Shika-2one is running at its full power,are shown in the upper panels in Fig 6.For comparison we also show the spectrum expected with all the main 17reactors operating at their full strength.A comparison of the upper and lower left-hand panels indicates that with the Kashiwazaki complex switched off,the distortions in the expected spectrum for the low-LMA solution become smaller.We note that even though the spectra corresponding to the high-LMA and low-LMA solutions and measured with the SK-Gd detector are less overlapping,the difference in the spectral shape for the two solutions diminishes when the Kashiwazaki plant is not operating.Thus,it could be possible with a value of ∆m 221in the high-LMA zone,to describe the data simulated at the “true”low-LMA solution point.However,in this case a somewhat larger value of sin 2θ12is required in order to explain the larger reduction of the event rate corresponding to the value of ∆m 221of the “true”low-LMA solution.This is what we get in Fig.5,where the spurious high-LMA solution gets allowed with a higher value of sin 2θ12.To stress the importance of having an experimental set up in which there are no cancellations between SPMIN and SPMAX due reactors at very different distances,we consider a hypothetical3456789101112E vis (MeV)00.20.40.60.8low−LMA high−LMA 00.20.40.60.81r a t i o o f e v e n t s w i t h t o w i t h o u t o s c i l l a t i o n s Gadzooks with 3 years datalow−LMA high−LMA Kashi switched off Kashi switched off 2345678E vis (MeV)00.20.40.60.8low−LMA high−LMA with 16 reactors with 17 reactors with 16 reactors with 17 reactors 00.20.40.60.81KamLAND with 3 KTON−YEAR data low−LMA high−LMA Figure 6:The ratio of the number of e +−events in the cases of oscillations and of absence of oscillations with their 1σerrorbars,expected at SK-Gd (3years of data)and KamLAND (3kTy of data)experiments.The Shika-2reactor is supposed to be operating.The upper panels are obtained assuming that the Kashiwazaki-Kariwa power plant is completely switched off,while the lower panels correspond to all the 17reactors,including Kashiwazaki-Kariwa and Shika-2,working.The dashed (solid)lines correspond to the low-LMA (high-LMA)solution.situation where only one reactor is operating.As a concrete example we consider a scenario where only the Shika-2reactor is operating.The flux from this reactor would produce a SPMIN in the e +−spectrum detected at SK-Gd if low-LMA was the correct solution.We show in Table 1the range of allowed parameter values and the corresponding spread at 99%C.L.obtained with 7years of data recorded in SK-Gd,when only Shika-2is operating.The improvement in the precision of sin 2θ12measurement is seen to be remarkable.4Combined Impact of Solar and SK-Gd DataIn Fig.7we present the allowed regions obtained by a combined analysis of the current global solar neutrino data and prospective SK-Gd data,expected after 3years of running of the proposed SK-Gd experiment.The left-hand panel shows the case of low-LMA being the true solution of thesolar neutrino problem;we simulated the SK-Gd data at ∆m 221=7.2×10−5eV 2and sin 2θ12=0.3.The right-hand panel illustrates the scenario we would witness if against the current trend,the next set of data from the KamLAND experiment would favor the high-LMA solution.The SK-Gddata for the right-hand panel is simulated at ∆m 221=1.5×10−4eV 2and sin 2θ12=0.3.。