1、SCLM Chapter 05
【总裁大人轻一点】浪漫言情:浪漫言情
【总裁大人轻一点】浪漫言情:浪漫言情话题:浪漫言情总裁大人轻一点居家生活策划案副作用母亲的男人女人总裁大人轻一点爱情通常都是一念之差,最幸福的不过就是,你曾温柔呼唤,而我恰好有过应答。
抓奸走错房,她被那个神秘的男人吃干抹净。
第二天一早,正牌老公带着一**记者涌进来反抓奸,狼狈不堪的她跳窗逃离。
再见面,他是执行总裁,她是天才设计师,他开始向她张开天罗地网。
★★凌御行,A市叱咤风云运筹帷幄的集团总裁,出身红色贵族,爷爷是军区司令,父亲领上将军衔,依着雄厚的家世背景,年纪轻轻便玩转军政商三界。
面对一个结了婚的女人,他食髓知味,步步引诱算计,只为把她收入囊中。
却不想,低估了她的智商,爱情局中局,还把自己给算计进去了。
★★【情节一】“乘乘,陪他一晚,我放你走。
”“严子饶,我是你老婆,你竟然把我送给别的男人?你无耻!”“只要一晚,你要什么我都答应你!”“我要离婚!”★★【情节二】“凌先生,我被扫地出门了,让我混口饭吃呗?”“可以,我给你一个公司,你去管理,赢了算你的,赔了算我的。
”一个月后,公司面临被收购场面。
某女视死如归半夜爬上龙床,准备把自己打包奉上。
“小乖,下次换点新招数安抚军心!”“凌先生,对付你,老娘一向奉行招不在新,管用就行。
”“那好,上贼船了,等会别喊着下船!”“唔……”第四十四章:害怕了么?好不容易熬到比赛结束,千乘看了眼身旁依旧一脸淡定的男人,似乎并没有离开的念头,满心的浮躁再度漫了上来。
今天,她面前的男子,白色的POLO衫搭配卡其色长裤和浅色系休闲鞋,本身就带着一股与生俱来的尊贵的气息,完美倨傲的身材在合宜的衣服衬托下,更加出众夺目!不同于之前严肃的西装,衣着休闲服的模样,让他看起来更加的闲适优雅!像他这样出众非凡的男人,越是心思深沉得让人难以捉摸!就在她看得有些出神的时候,身旁的男人突然起身,一把拉过她的手带着她往外走,一旁还愣着的唐锦铭愣愣然的跟着起身追了过来,身后那**公子哥儿看着这场景,纷纷摸不着头脑。
高考英语一轮选择性必修第一册Unit1Laughoutloud外研版
or funny movements. 能力提升——微写作 ③这些游乐场为游客提供娱乐与教育相结合的体验,值得我们关注。
These amusement parks offering visitors experience
t_h_a_t c_o_m_b_i_n_es_e_n_t_er_ta_i_nm__e_nt_w_i_th__ed_u_c_a_ti_o_n deserve our attention.
(1)entertain sb. with sth. 用某物使某人快乐 entertain sb. to sth. 用某物招待某人 (2)to one's entertainment 使某人高兴的是
3spot vt.发现;认出;点缀 n.处所;斑点;污点;地点 基础练习——单句语法填空 ①[2022·新高考Ⅰ卷]I looked around and finally __s_p_o_tt_ed__ (spot) David,
deserves __p_a_y_in_g__ (pay) attention to. ②Mary is constantly making efforts, and her teachers remark that she
畅销巨作向奚宋清渊宋清渊罗茜完整版在线阅读
畅销巨作向奚宋清渊宋清渊罗茜完整版在线阅读《向奚宋清渊》第1章本站最新上架的优质新书,言情小说《向奚宋清渊》,书中关键人物分别,讲述一段缠绵悱恻的爱情,故事内容简介:伤害到底是造成了。
自从和宋清渊结婚之后,她不肯让宋清渊碰他。
即便如此,宋清渊还是小心翼翼的维护这段婚姻。
除了每日辛苦工作,下班之后还要照看儿子,做饭,做家务,甚至打好了洗脚水给她。
即便这样,也没捂热向奚的心...《向奚宋清渊》免费试读怒吻如狂风骤雨袭来,向奚瞳仁震颤着,看着眼前熟悉又陌生的脸,陷入一连串震动!宋清渊?环顾四周,光线充足的大瓦房,墙壁粉刷的白净平整,皮革沙发小茶几,席梦思大床上悬挂着的赫然是她和宋清渊的结婚照!她和宋清渊不是离婚了?还没等向奚回过神来,巴掌不受控制,重重的落在宋清渊的脸上!“啪”的声,向奚愣住。
眼前宋清渊的脸年轻紧致,没有岁月雕凿的痕迹,俊美的令人怦然心动,可惜被通红的巴掌印破坏殆尽。
他此时咬着牙,目眦欲裂,眼尾通红,克制和汹涌的怒火在这张脸上彰显的淋漓尽致。
只一眼,就将向奚带入了多年前的爱恨纠葛中,心口像被大掌重重揪着,喘不上气来。
“向、奚!和我结婚之后,你可曾喜欢过我,哪怕只有一点点?”宋清渊一字一句,愤怒的气音从齿缝嘶泄,漆黑瞳仁酝酿着风暴,脸上浮现的五指山,将他衬有些可怖。
认识宋清渊这么多年,他向来斯文自持,从未失控,只除了她提出离婚的那天!电光火石间,向奚悟了。
她重生了!回到了和宋清渊离婚的前一天!前世她被程子黔的甜言蜜语蛊惑,狠心抛夫弃子,带着丰厚嫁妆嫁给程子黔。
没想到程子黔是个坏的,利用她的嫁妆做生意飞黄腾达之后,立马和叶明珠勾搭,狠心将她抛弃。
她为了程子黔众叛亲离,被绿后悲痛欲绝,吐血病重,后来更是凄惨的死在出租屋里。
死后,她亲眼看到宋清渊带着儿子来给自己敛尸,彼时的宋清渊已是功成名就,一跃成为了全国首富。
她看着那个身形颀长的男子,将玫瑰花打落在她墓前,蹲下身讽刺的抚摸她的墓碑。
“向奚,你后悔吗?”向奚后悔莫及。
虐心文
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Fujitsu PRIMERGY Linux安装后操作指南(适用于x86版本3.0)说明书
2005-11-01 Notes on Using Red Hat Enterprise Linux AS (v.3 for x86) PrefaceAbout This ManualThis manual provides notes on PRIMERGY operation with Linux installed. Be sure to read this manual before using Linux.Intended ReadersThis manual is intended for persons who operate PRIMERGY.Organization of This ManualThis manual consists of the following chapters:Chapter 1 Notes on OperationThis chapter provides notes on operation after installation. Be sure to read this chapterbefore operating PRIMERGY with Linux installed.Chapter 2 Addition of Peripheral Devices and Option CardsThis chapter explains the procedures for adding peripheral devices and cards afterinstallation and provides notes on adding these options. Read this chapter as required.Chapter 3 OthersThis chapter explains other functions and provides other notes such as notes on limits.Operation VerificationThe operations of the products described in this manual have been confirmed by Fujitsu. Please note, however, that these operations are subject to change without prior notice.Support & ServiceA support service(SupportDesk Product basic service), available for a fee, provides customers usingLinux with an enhanced sense of security and confidence. Customers concluding a support and service agreement are entitled to receive support in such areas as assistance with queries regarding this manual and questions and problems that may come up during the installation and operation of this product.Please consider taking advantage of this service option by concluding a support and service agreement with us.CopyrightAll rights Reserved, Copyright (C) FUJITSU LIMITED 20051. Notes on Operation1.1 Assignment of Device NamesLinux assigns device names to a variety of devices, such as the hard disk drive, in the order that it recognizes them during its startup sequence. If the system is restarted after a device such as a hard disk drive or controller fails, the assigned device names may be changed because the system cannot recognize a device that has failed.Example: When hard disk drives are connected to SCSI ID 1, 2, and 3, device names /dev/sda, /dev/sdb, and /dev/sdc are assigned respectively to the disk drives. If /dev/sdb failsunder this condition, the device previously assigned /dev/sdc/ is moved up by one andrecognized as /dev/sdb after the system is restarted.If an assigned device is unexpectedly changed, it may prevent the system from starting or,in the worst case, may damage your data. If a device fault is detected, therefore, Fujitsurecommends starting the system in rescue mode and checking for hardware faults beforerestarting the system (*1). Repair the hardware fault, restore the system by means suchas the backup tape, and then restart the system.*1 For details on starting the system in rescue mode, see Section 1.4, "Starting theSystem in Rescue Mode."After starting the system, use the fdisk command to check whether the relevant hard diskdrive can be recognized, and take necessary steps such as checking for hardware errormessages in /var/log/messages.1.2 Installation of Red Hat Enterprise Linux AS (v.3 for x86) PackagesRed Hat Enterprise Linux provides installation types so that the optimum system can be constructed according to the use purpose. For this reason, packages required for your purposes might not be installed. If a required package has not been installed, log in as the root and install it by executing the following procedure:Install the necessary packages by using the installation CDs (1/4 to 4/4) that have beencreated according to the Installation Procedure included in the driver kit.# mount -r /dev/cdrom /mnt/cdrom# cd /mnt/cdrom/RedHat/RPMS# rpm -ivh <package_file>Example: To install package "make"# rpm -ivh make-3.79.1-17.i386.rpm# cd /# umount /mnt/cdrom# eject* Remove the CD.1.3 Installing and Setting Up Global Array Manager (GAM)Use Global Array Manager (GAM) as a RAID management tool in a system with a mounted onboard SCSI-RAID and SCSI-RAID card (PG-142E3).For details on installing GAM-Client (Windows), see "Outline of Installation Procedure for Global Array Manager-Client", which is an attachment.The GAM-Server (Linux) installation procedure is explained below.[Notes]1)The screen display may become unstable during GAM installation or GAM service startup.This is not an operational problem.2)Specify the port numbers shown below for GAM service.Take care when configuring firewall settings.Port numbers: 157,158(1)To install GAM-Server (Linux), insert the driver CD into the CD-ROM drive, and entercommands as follows:# mount -r /dev/cdrom /mnt/cdrom# cd /mnt/cdrom/UTY/GAM/Linux# rpm -ivh gam-server-6.02-21.i386.rpm# rpm -ivh gam-agent-6.02-21.i386.rpm- Enter the following only if onboard SCSI for RX200 S2# rpm -ivh 1030SNMPAgent-2.4-3.i386.rpm# sh ./insgam* Confirm that “GAM is installed successfully.” is displayed.# cd /# umount /mnt/cdrom# eject* Remove the CD.(2)For user accounts in Linux, create "gamroot" as a user account with GAM administratorauthority and then create user accounts (e.g., "gamuser") with user authority.(If a user account with user authority has already been created, another account need not be created.) # adduser gamroot# passwd gamrootChanging password for user gamrootNew-password <--- Enter a password.Retype new password <--- Re-enter the same password for confirmation.passwd: all authentication tokens updated successfully* Create a user account with user authority in the same way as explained above.(3)Edit three lines as shown below in the /etc/sysconfig/gam file.Events can be posted to GAM-Client after this editing is completed.# vi /etc/sysconfig/gam[Before editing]START_GAMEVENT=nGAMEVENT_OPTIONS=""[After editing]START_GAMEVENT=y <--- Change "n" to "y".GAMEVENT_OPTIONS="-h ip-address" <--- Specify the IP address of the managementWindows system on which GAM-Client isinstalled.[Before editing]START_GAMEVLOG=n[After editing]START_GAMEVLOG=y <--- Change "n" to "y".(4)Restart the system.# shutdown -r now* The following message may be displayed after the system starts. It does not indicate an operational problem.[Message]gamagent: gamagent: Connection refusedgamagent connect failure1.4 Starting the System in Rescue ModeUsing only one of the installation CDs that have been created according to the Installation Procedure included in the driver kit, you can start the system in rescue mode. This may enable system recovery in the event of a problem that prevents the system from starting normally.This section explains only how to start the system as one that has minimum functionality.Start the system in rescue mode as follows:(1)Start the system from installation CD 1/4 that was created according to the InstallationProcedure included in the driver kit. Enter the appropriate response in the following window,and press the [Enter] key.(2)In the Choose a Language window, select "English" and select "OK."(3)In the Keyboard Type window, select "jp106" and select "OK."If an accessory keyboard such as of a flat display (PG-R1DP3) is used, select "us" here.(4)In the following window, select "Yes."(5)In the following window, select "Add Device."(6)In the Driver List window, select the drivers for the devices installed in the system, and select"OK." The following drivers must be selected:[onboard SCSI type for TX200 S2][onboard SCSI type or onboard SCSI-RAID type for RX200 S2]Two drivers must be selected. Select drivers as follows:1.Select the driver shown below, and select "OK.""LSI Logic Fusion MPT Base Driver (mptbase)"2.The Device Selection window is displayed. Select "AddDevice."3. A list of drivers is displayed. Select the driver shown below, and select "OK.""LSI Logic Fusion MPT SCSI Driver (mptscsih)"[SCSI-RAID card(PG-140D1/PG-142E3) for TX200 S2][onboard SCSI-RAID type for RX300 S2]Select the driver shown below, and select "OK.""LSI MegaRAID controller (megaraid2)"(7)Make sure that the selected driver is displayed in the following window, and select "Done."(8)The Setup Networking window is displayed. Select "No" because network settings need not beconfigured at this time.(9)Select "Continue" in the Rescue window.(10)If the root partition (/) in the existing Linux system has been mounted successfully under/mnt/sysimage, this is reported in the Rescue window. Select "OK."(11)When the prompt is displayed, enter the chroot command to change the root path to the harddisk drive.sh-2.05b# chroot /mnt/sysimage(12)This completes startup in rescue mode. To exit rescue mode, enter the exit command twice.sh-2.05b# exit <--- Exit from the chroot environment.sh-2.05b# exit <--- Exit from the rescue mode.1.5 Power-off at ShutdownPower is not automatically turned off at shutdown.When [Power down] is displayed on the console screen, press the power switch to turn off the power.Note that the power is automatically turned off when the system is shut down in an environment in which ServerView is installed.2. Addition of Peripheral Devices and Option Cards2.1 Adding a SCSI DiskThe number of LUNs is set to 1 by default. To add a SCSI disk, shared disk, or tape library, log in as the root and define the number of LUNs as shown below. Multiple LUN referencing is enabled after the system is started next.(1)Add the following lines to /etc/modules.conf:options scsi_mod max_scsi_luns=N <--- Add* N is the number of LUNs. Define the appropriate number.(2)Enter the mkinitrd command to create initrd.To create initrd, enter the mkinitrd command appropriate for the type of kernel used.* Enter the following command to check the type of kernel used:# uname -r[2.4.21-32.0.1.EL (kernel for single CPU)]# cp /boot/initrd-2.4.21-32.0.1.EL.img /boot/initrd-2.4.21-32.0.1.EL.img.bak# mkinitrd -f /boot/initrd-2.4.21-32.0.1.EL.img 2.4.21-32.0.1.EL[2.4.21-32.0.1.EL smp (kernel for multi-CPU)]#cp /boot/initrd-2.4.21-32.0.1.ELsmp.img /boot/initrd-2.4.21-32.0.1.ELsmp.img.bak# mkinitrd -f /boot/initrd-2.4.21-32.0.1.EL smp.img 2.4.21-32.0.1.EL smp(3)Restart the system.Enter the following command to restart the system.# shutdown -r now2.2 Adding Option CardsIf any of the option cards supported by the models listed in the following table is added after system installation, kudzu is automatically started at system startup. This section explains the operations that enable the system to automatically recognize the added card at each subsequent system startup.The table lists models and the option cards supported by them.TX200 S2 RX200 S2 RX300 S2PG-128 V -- -- SCSI cardPG-130L -- V V PG-140D1V V -- SCSI-RAID cardPG-142E3V V -- PG-1852 V V -- PG-1853 V -- -- PG-1853L -- V -- PG-1862 V V -- PG-1882 V -- -- PG-1882L -- V V PG-1892 V -- -- LAN cardPG-1892L -- V V PG-FC106V V V onboard Fibre-Channel cardPG-FC107V V VSCSI cardPG-128 -- -- V SCSI-RAID cardPG-142E3-- -- V PG-1852 -- -- V PG-1853 -- -- V PG-1862 -- -- V PG-1882 -- -- V LAN cardPG-1892 -- -- V PG-FC106-- -- V Raiser Card Fibre-Channel cardPG-FC107-- -- VV: Supported --: Not supported- TX200 S2 or RX300 S2If any of the option cards supported by the models listed in the above table is added after system installation, kudzu is automatically started at system startup. To add a fibre channel card, follow the steps below. Except for a fibre channel card, select "configure."To add a LAN card, configure network settings according to the instructions displayed in the window. Login as a root user at system startup, and perform the operations explained in Section 2.3, "Executing mkinitrd."This section explains the operations that enable the system to automatically recognize the added card at each subsequent system startup.[A fibre channel card is added](1)If a fibre channel card is added after system installation,kudzu is automatically started at system startup.Always select "ignore ."(2)Add the following line to /etc/modules.conf.If SCSI or SCSI-RAID device is installed in the system,number the end of "scsi_hostadapter", as "2, 3, ...".options scsi_mod max_scsi_luns=128 Add- RX200 S2If any of the option cards supported by the models listed in the above table is added after systeminstallation, kudzu is automatically started at system startup.To add a fibre channel card or LAN card, follow the steps below.Except for a fibre channel card and LAN card, select "configure." Login as a root user at system startup, and perform the operations explained in Section 2.3, "Executing mkinitrd."This section explains the operations that enable the system to automatically recognize the added card at each subsequent system startup.[A LAN card(PG-1852, PG-1862, PG-1882L or PG-1892L) is added](1)If any of the LAN cards supported by the models listed in the above table is addedafter system installation, kudzu is automatically started at system startup.Always select " ignore."(2)Add the following lines to /etc/modules.conf.[ PG-1852, PG-1853L,PG-1892L, or PG-1882L]alias eth0 e1000alias eth1 e1000alias eth2 e1000 <--- Add[ PG-1862]alias eth0 e1000alias eth1 e1000alias eth2 e1000 <--- Addalias eth3 e1000 <--- Add(3)Set up the network.[ PG-1852, ,PG-1853L ,PG-1892L, or PG-1882L]# netconfig -d eth0# netconfig -d eth1# netconfig -d eth2[ PG-1862]# netconfig -d eth0# netconfig -d eth1# netconfig -d eth2# netconfig -d eth3[A fibre channel card is added](1)If a fibre channel card is added after system installation,kudzu is automatically started atsystem startup.Always select "ignore ."(2)Add the following line to /etc/modules.conf.If SCSI or SCSI-RAID device is installed in the system,number the end of "scsi_hostadapter",as "2, 3, ...".options scsi_mod max_scsi_luns=128 Add2.3 Executing mkinitrd(1) Create initrd by executing the mkinitrd command.Create initrd by executing the mkinitrd command according to the kernel used.* Enter the following command to check the kernel used:# uname -rCommand execution examples are shown below.[2.4.21-32.0.1.EL (kernel for a single CPU)]# cp /boot/initrd-2.4.21-32.0.1.EL.img /boot/initrd-2.4.21-32.0.1.EL.img.bak# mkinitrd -f /boot/initrd-2.4.21-32.0.1.EL.img 2.4.21-32.0.1.EL[2.4.21-32.0.1.EL smp (kernel for multi-CPUs)]# cp /boot/initrd-2.4.21-32.0.1.EL smp.img /boot/initrd-2.4.21-32.0.1.ELsmp.img.bak# mkinitrd -f /boot/initrd-2.4.21-32.0.1.EL smp.img 2.4.21-32.0.1.EL smp(2) Restart the system.Restart the system as follows:# shutdown -r now3. Others3.1 Sound FunctionNo sound function is supported.3.2 PCI Hot Plug FunctionThe PCI hot plug function is not supported.3.3 Usable KernelsThe kernels that can be used vary depending on the hardware conditions.See the table below for the kernels that can be used.Note that middleware specifications might limit the kernel to be selected. In this case, select the kernel in accordance with the middleware specifications.Hardware conditionsKernel to be selectedMemory Number of logical CPUs (*1)for single CPU1CPU Kernel Up to 4 GB2 or more CPUs Kernel for multi-CPUMore than 4 GB and up to 8 GB No conditions Kernel for multi-CPU(*1) Even when only one CPU is installed, the number of logical CPUs is 2if Hyper Threading = Enabled.3.4 Distribution LimitationsOperation is not guaranteed if one of the following CPU, memory, and file system limitations is exceeded:Maximum number of logical CPUs: 16Maximum memory size: 8 GBFile system: Less than 1 TB3.5 Installation ProcedureFor information on the procedure for installing Red Hat Enterprise Linux ES (v.3 for x86), see the Installation Procedure included in the "Installation Kit" downloaded from Download Search.Attachment Outline of Global Array Manager Client Installation* Perform this operation only when an onboard SCSI-RAID or a SCSI-RAID card (PG-140D1 or PG-142E3) are mounted.* GAM-Client runs on Windows2000 and Windows2003. Prepare a management Windows system.1. Insert the driver CD into the CD-ROM drive in the management Windows system.2. Execute setup.exe in RHEL3¥UTY¥GAM¥Windows on the driver CD.3. When the "Welcome" window is displayed, click "Next."4. The "Software License Agreement" window is displayed. Read the statements and click "Yes" if youaccept the terms of this agreement.5. The "Select Components" window (Figure 1) is displayed. Confirm that the check box before "GlobalArray Manager Client" is selected. Clear the "Global Array Manager Server" and "SAN Array Manager Client" check boxes, and click "Next."Figure 1* "SAN Array Manager Client" is not supported. Do not install it.6.The "Choose Destination Location" window is displayed.Click "Browse," specify the location that you want as the installation destination, and click "Next."* If GAM-Client is already installed, a message confirmingwhether to overwrite is displayed. Click "OK" to continue.7. A dialog box for specifying the GAM-Client installation destination is displayed. Click "Next." and thesetup program starts copying files.8. The "Setup Complete" window is displayed.Click "Finish" to exit the GAM-Client installation wizard.-- END --。
爱情与金钱(中英对照)_书虫系列
目录1 Chapter (2)2 Chapter (6)3 Chapter (16)4 Chapter (24)5 Chapter (32)6 Chapter (41)7 Chapter (47)Love Or Money爱情与金钱1 Chapter1The Clarkson family lived in the country near Cambridge,about half a mile from the nearest village and about a mile from the river.They had a big,old house with a beautiful garden,a lot of flowers and many old.trees.克拉克森家住在剑桥附近的乡下,离最近的村庄约有半英里路,距离河有1英里左右。
他们有幢大而古老带有美丽花园的房子,花园里有许多花和许多古树。
One Thursday morning in July,Jackie came in from the garden.She was a tall,fat woman,thirty years old.It was the hottest day of the year,but she wore a warm brown skirt and yellow shirt.She went into the kitchen to get a drink of water.Just then the phone rang.7月的一个星期四早上,杰基从花园进了屋。
她是个高大,肥胖,30来岁的女人。
这是一年中最热的日子,而她却穿着暖色调的黄色衬衫和棕色裙子。
她走进厨房去喝水,这时电话响了。
'Cambridge 1379,'Jackie said.“剑桥1379号,”杰基说。
'Hello.This is Diane.I want to talk to Mother.'“你好!我是黛安娜。
小薄荷星(五)
小薄荷星(五)作者简介:薄皮大馅,专注甜文的相声派写手,极其擅长逗猫、遛狗与做白日梦。
努力学习与发际线治疗并行中,希望你一见我就笑。
已出版作品:《月光着陆》上期回顾:简澄虽然看似对向林洲表白十分胆大,实质上并无进展,而且以向林洲为原型画的漫画还遇到了瓶颈,看不过去的室友推荐简澄去电影院找找灵感……如果不是“病急乱投医”,无辜的简澄同学是不会选择在周末大好的晚上,到学校的小电影放映厅去自取其辱的。
她有时候真的觉得他们学校的学风,是不是有点儿过于开放了?一整个放映厅都是两个两个排在一起的座位,这会儿塞满了姿态亲密的男男女女,她斜前方的一对小情侣已经过分到把两个座位中间的扶手抬上去,紧紧贴着坐在一块儿了。
男生:“宝贝,吃爆米花吗?”女生:“想吃,但是要宝贝喂我哦!”简澄心想,跟你们这两个二十来岁的小宝贝考上同一所大学,我也真是挺不容易的。
她坐在放映厅最后方,俯瞰的视野也很好,小情侣们都坐在前面,她自己独占一排,非常威风。
可惜这种威风只维持了两分钟,在厅里灯全都熄灭,电影幕布拉下,男主穿着校园男神最爱的白衬衫,骑着单车出场的时候,有一道身影和她隔着一条走道坐了下来。
放映厅里的空气本来是沉闷湿热的,但那人却像是带来了一阵清爽的凉风,含着淡淡的薄荷的气息,悉数涌进了她的鼻腔里。
几乎是第一时间,简澄心中就浮现了一个名字。
她转过头,在电影屏幕忽明忽暗的微弱光线中,捕捉到了熟悉的英俊轮廓。
——在这里都能碰见。
——她和向林洲也是真的“锁”了吧。
向神不是单纯来看电影的。
昨天和教授讨论完ACM竞赛的事后,他就开始着手找队友组队伍,本来和一个大三学长约好了今晚见一面,结果不料撞上对方异地恋的女朋友飞过来看他。
计划泡汤,学长自知理亏,带女朋友看电影之余,还不忘也给他塞了张票作为弥补。
向林洲看过的文艺片很少,文艺片中的爱情片更是凤毛麟角,本来没打算进来看,但最近忙的事情很多,他近一周都没怎么好好休息过,这会儿回寝室,有室友在打游戏,不见得会比放映厅安静。
1--Silver.Theory in Relation to Research and Practice
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《最后期限》书籍
《最后期限》书籍"这本关于治理的书读起来明白有味。
«最后期限»是一个创新性与趣味性并重的故事,每章结尾都有基于团队的项目治理方面的原那么。
"--John Aculley"……这是一部技术力作。
它涵盖了大量主题,从项目评估到度量标准,从相冲突的决定到处理模糊不清的说明…每章结尾的要点差不多足以让您这本书成为超值之选了……«最后期限»像Dilbert的漫画书一样有味,却没有那么讽刺。
更重要的是,书中包括一些深刻的聪慧,以及一些关心您实现最后期限的有用积极的建议。
我强烈举荐这本书。
"--Ed Yourdon 内容与特色:汤普金斯先生是一位体会丰富的项目经理,却也难免被炒鱿鱼的命运。
这时有人出双倍的价钱将他"请"到一个海上的小国治理六个软件项目,资金、人员、设备等所有外部条件都万事俱备,能够放手去做,还能够将自己的奇思妙想付诸实践。
本以为因祸得福,却逐步发觉情况并没有那么简单,最后期限看起来变得不可能,但他已骑虎难下……书中用一个虚构的故事阐述了真实世界中关于项目治理的一些原那么,尽管它并不能解决任何软件问题,但它绝对会让你对项目治理的重要原那么终生难忘。
它将看似高深莫测的项目治理理论以浅显易明白的方式展现出来,改变了项目治理书籍一贯枯燥乏味的形象,让你在轻松阅读小说的同时受益非浅。
书中每章都以汤普金斯先生的日记结尾,是他逐步收集的体会,有了这些,你也能够成为一个优秀的项目b经理。
本书前言在二十世纪三十年代,科罗拉多大学的物理学家乔治.伽莫夫开始撰写一系列关于"汤普金斯先生"--一位中年银行职员--的小故事。
故事中讲述的汤普金斯先生对现代科学专门感爱好。
他总是去听当地一位大学物理教授在晚上的演讲,然后在中途他必定会睡着。
当他醒来的时候,他会发觉自己身在另一个宇宙之中,在那儿某个物理常量发生了明显的变化。
口琴曲谱
三首《犬夜叉》插曲的简谱犬夜叉《超越时空的思念》,此曲为犬夜叉剧场版插曲,及其忧伤,婉如凋零的花朵,有兴趣的,可以上百度搜一下。
()为高音,[]为底音。
然而,吹奏时,无需完全按谱走,可以自行改变乐曲的八度。
356 6(1)(2) (3)(5)(3) (2)(1)6 (3)(2)6 (3)(2)6 53 356 6(1)(2) (3)(5)(3) (2)(1)6 (3)(2)6 (3)(2)6 56 356 56 756 523 356 56(1)753 356 56 756 523 32[6] 32[6] 56 356 56 756 523 356 56(1)753 356 56 756 523 32[6] 32[6] 56 (3)(2)6 (3)(2)6 56运命と恋心:26543212 67(1)(1)7656 26543212 23432132456(1)7656465 456(1)(3)(1)76 456(1)7656465 23434545626543212 67(1)(1)7656 26543212 23432132慕情:3 235 423 235 42321<6> <5><6><7><6><5><3><6><7>123 235 423 235 42321<6> <5><6><7><6><5><6><6><7>123 235 423 235 42321<6> <5><6><7><6><5><3><6><7>123 235 423 235 42321<6> <5><6><7><6><5><6>《银之意志,金之翼》——剑帝的角色歌,游戏中由小提琴演奏(其实是合成音乐),相信玩过游戏的朋友都熟悉这首歌吧?其实还有一个慢节奏的,3rd中,与剑帝决战之后便出现的那首,旋律一样,就是节奏变慢了。
SCLM文档增补说明书
impact upon documentation. 2. The enhancements and corrections described in this section are only available
Chapter 19, ″SCLM macros″ v FLMCNTRL macro v FLMALTC macro
OA20514
Additional parameters for GETBLDMP SCLM service.
See changes marked with a change bar (″|″) in these sections:
after applying the listed APARs.
© Copyright IBM Corp. 1990, 2008
v
vi Addendum to the SCLM documentation
PTF/APAR documentation changes
There are no PTF/APAR documentation changes contained in this Addendum.
Chapter 16. ″Invoking the SCLM Services″ ISPF Variables
Chapter 17. ″SCLM Services″ GETBLDMP
SCLM Messages and Codes V1 R9 (SC34-4815-07)
OA21740
Cross-dependency database.
供应链物流SCLM
铁路货运供应链物流管理SCLM整体解决方案关键字:铁路货场铁路物流供应链管理供应链物流SCLM 铁路货运信息化供应链物流管理(Supply Chain Logistics Management,简称SCLM),是指以供应链核心产品或者核心业务为中心的物流管理体系。
SCLM也是一种物流管理,它和通常的物流管理没有本质的区别。
它同样包括运输、储存、包装、装卸、加工和信息处理等。
SCLM主要是通过信息管理来实现,通过物流系统,缩短物流活动的周期,加快物流速度。
我们amiue一直致力于物流信息领域的SCLM系统研究,与铁路总公司、铁科院等机构合作,面向铁路物流领域开展相关业务。
为铁路货场、物流园区、铁路物流基地、城市配送中心、铁路物流企业、物资生产商、零售商、货主企业等提供SCLM解决方案。
一、铁路货运物流行业的业务模式和特点分析运输工具铁路物流行业采用的运输工具和运输形式多样化,包括但不限于:铁路整车、铁路集装箱、自备车、自备箱、铁路零担、铁路零散货物快运、特种车辆、特种集装箱。
同时,铁路物流也在短途运输的时候采用汽车运输方式。
仓储类型铁路货场的仓库有:传统的露天库、露天堆场、雨棚站台,近几年,随着铁路货运体制改革,铁路货场的扩建和改造,铁路的仓库也有了较大的升级,立体库、室内库不断兴起,低温库、超低温库、危险品库等也开始出现。
物流配送模式铁路的配送一般称为“接取送达”,主要包括发到站的“送货上门”“上门取货”服务,主要采用汽车运输方式,自有车辆、社会加盟车辆、货主自有车辆多种模式并存。
综上所述,铁路物流有自身的行业特点:既有传统业务又有新兴社会化业务,粗放和精细两种模式共存。
∙多网点、多货主、多仓库,跨区域运营,整合社会资源参与业务流程∙货运量大,品类多、客户费收体系复杂,管理难度高。
二、铁路物流行业的管理特点和要求铁路物流行业推行多级管理的模式,如:总公司-路局-站段、集团-分公司-网点。
根据铁路运输的组织架构特点,归纳铁路物流企业的管控需求:①集团需要全面掌握各分公司网点的运营情况②业务网点需要全面掌握业务流程中各个环节的运行情况。
欧洲药典5.5_GAOQS
COMMENTS CONCERNING SOME REVISED/ CORRECTED TEXTS PUBLISHED IN SUPPLEMENT 5.5Here follows information concerning certain technical modifications to some revised/corrected texts adopted by the European Pharmacopoeia Commission at the June 2005 session. This information completes the modifications indicated by lines in the margin in the supplement. Therefore, the information below is not necessarily exhaustive.ANALYTICAL METHODS2.4.29. Composition of fatty acids in oils rich in omega-3-acidsIn the test for system suitability, as in the case of thetest for oligomers in the omega-3-acid ethyl esters 90 monograph, the fi rst 3 requirements are consideredsuffi cient; the 4th requirement is not routinely performed by the producers who proposed the test, and is deleted. 2.6.15. Prekallikrein activatorThis general chapter has been revised based on the outcome of the international collaborative study BSP049 organised by the EDQM, to mention that a microtitre plate-based method, which is nowadays the most frequently used, may also be used instead of methods using autoanalysers, which were more appropriate whena large number of samples had to be analysed.2.6.21. Nucleic acid amplifi cation techniquesThis general chapter has been revised to makeit applicable to new applications such as the testfor mycoplasmas (see revised chapter 2.6.7) anda quantitative test system used to control anti-Dplasma for B19 virus (see monograph Human anti-D immunoglobulin (0557)).2.6.22. Activated coagulation factorsThis general chapter has been revised together with general chapters 2.7.11 and 2.7.22 to:— change protamine sulphate R to being an example of a suitable substance to neutralise the heparin;— replace the reference to cephalin R and platelet substitute R, which were obsolete, by a phospholipid preparation to act as a platelet substitute.2.7.4. Assay of human coagulation factor VIIIThe assay of human coagulation factor VIII using a chromogenic substrate was fi rst included in the European Pharmacopoeia in 1993, replacing the two-stage assay,in line with the recommendation of the Scientifi cand Standardisation Committee of the International Society on Thrombosis and Haemostasis (SSC ISTH). Commercial kits are used for the assay and the description of the method is generic to allow the use of all currently available kits with acceptable performance. The revision brings no essential major changes to the method. Work has been carried out recently to defi ne critical aspects of the method, particularly with respect to B domain-deleted factor VIII. Problems encountered with the latter product are best resolved by the useof a B domain-deleted factor VIII reference standardfor routine assay. The experimental work carried out recently indicates that it is best for these products to halt factor Xa generation when the factor Xa concentration has reached approximately 50 per cent of the maximum (plateau) level. Furthermore, since it has been shown that, from a statistical point of view, the potency found with independent or serial dilutions is not signifi cantly different, independent dilutions are no longer required. 2.7.11. Assay of human coagulation factor IXThis general chapter has been revised to:— mention factor IX-defi cient plasma as a predilution medium, since this is used routinely;— allow the use of commercial APTT reagents and omit the reference to cephalin-based reagents, which are now obsolete.2.7.21. Assay of human von Willebrand factorThis general chapter has been revised to improve and supplement the description of ristocetin cofactor activity, and in particular to introduce general statements on quantitative assays. Furthermore, since it has been shown that, from a statistical point of view, the potency found with independent or serial dilutions is not signifi cantly different, independent dilutions are no longer required. 2.7.22. Assay of human coagulation factor XIThe general chapter has been revised to:— mention factor XI-defi cient plasma as a predilution medium since this is used routinely;— allow the use of commercial APTT reagents and omit the reference to cephalin-based reagents, which are now obsolete.5.10. Control of impurities in substances for pharmaceutical useThe section on Interpretation of the test for related substances in the monographs on active substances has been modifi ed to replace the examples by a decision tree, which better illustrates the interpretation of monographs.^_^ ---VACCINES FOR HUMAN USEDOSAGE FORMSGENERAL MONOGRAPHSSubstances for pharmaceutical use (2034)In the section dealing with related substances, the possibility of exemptions to the general provisions has been introduced, since it is now seen to be appropriate to make exceptions in some specifi c monographs.The section on residual solvents has been modifi ed tostate explicitly that the content of residual solvents is taken into account for calculation of specifi c optical rotation and specifi c absorbance.Capsules (0016)In order to take account of the new harmonised chapteron Disintegration, adaptations have been introduced to the relevant sections.Ear preparations (0652)The test for Deliverable mass or volume has been the cause of some misunderstanding amongst users: it was not a quality control test, and aimed only to ensure that the fi lling was such that the labelled dose could be withdrawn; furthermore, it has been considered to be vague and impractical. It has therefore been replaced by an additional sentence under Production.Liquid preparations for cutaneous application (0927)Liquid preparations for oral use (0672)The test for Deliverable mass or volume has been the cause of some misunderstanding amongst users: it was not a quality control test, and aimed only to ensure that the fi lling was such that the labelled dose could be withdrawn; furthermore, it has been considered to be vague and impractical. It has therefore been replaced by an additional sentence under Production.Rectal preparations (1145)The test for deliverable mass or volume has been the cause of some misunderstanding amongst users: it was not a quality control test, and aimed only to ensure that the fi lling was such that the labelled dose could be withdrawn; furthermore, it has been considered to be vague and impractical. It has therefore been replaced by an additional sentence under Production.Also, in order to take account of the new harmonised chapters on Dissolution and Disintegration, adaptations have been introduced to the relevant sections.Semi-solid preparations for cutaneous application (0132)The test for deliverable mass or volume has been the cause of some misunderstanding amongst users: it was not a quality control test, and aimed only to ensure that the fi lling was such that the labelled dose could be withdrawn; furthermore, it has been considered to be vague and impractical. It has therefore been replaced by an additional sentence under Production.Tablets (0478)This monograph was published in Pharmeuropa 15.2 and 16.2 for enquiry related to uniformity of subdivided tablets and to oral lyophilisates. Due to the comments received, it was necessary to carry out a new enquiry as regards oral lyophilisates (Pharmeuropa 17.4). As regards subdivision of tablets, uniformity of mass is now tested on 30 parts; no 2nd test is required in case of failure. This revision is the result of the enquiry and the study performed by the OMCLs on the basis of Pharmeuropa 16.2. This text also takes into account the new harmonised chapters on Disintegration and Dissolution.Vaginal preparations (1164)The test for deliverable mass or volume has been the cause of some misunderstanding amongst users: it was not a quality control test, and aimed only to ensure that the fi lling was such that the labelled dose could be withdrawn; furthermore, it has been considered to be vague and impractical. It has therefore been replaced by an additional sentence under Production.Also, in order to take account of the new harmonised chapters on Dissolution and Disintegration, adaptations have been introduced to the relevant sections.Pneumococcal polysaccharide conjugate vaccine (adsorbed) (2150)The monograph has been revised to clarify that the test for sterility that is carried out on intermediates (the pneumococcal polysaccharides, the carrier protein and the monovalent bulk conjugate) uses 10 ml for each medium or the equivalent of 100 doses, whichever is less. Furthermore, it harmonises this monograph with the monograph on Meningococcal group C conjugate vaccine (2112).^_^---MONOGRAPHSAluminium hydroxide, hydrated, for adsorption (1664) Based on batch data, the limit for iron has been increased from 10 ppm to 15 ppm.Beclometasone dipropionate, anhydrous (0654) Beclometasone dipropionate monohydrate (1709) Following the establishment of beclometasone dipropionate for system suitability CRS and beclometasone dipropionate for peak identifi cation CRS, the identifi cation of impurities D and M has beenmodifi ed. In addition, relative retentions of the other detectable impurities have been deleted according to usual practice.Benzyl alcohol (0256)In the test for residue on evaporation, the temperatureof 100 °C indicated for evaporation on a water-bath was too low in view of the boiling point of benzyl alcohol (205 °C), therefore the evaporation method has been changed.In the assay, it is now specifi ed that the mixture is heated on a water-bath.Digoxin (0079)This monograph has been revised to replace the TLCtest for related substances by LC and to replace the assay with an LC test using the same system. For this product of natural origin having a complex impurity profi le, it has not proved possible to apply the general policy for impurities shown in the monograph on Substances for Pharmaceutical Use (2034). It has been necessary to give an acceptance criterion equivalent to 0.2 per cent for “any other impurities”. An acceptance criterion for the sum of impurities (specifi ed and unspecifi ed) has been defi ned and in order to provide a further degree of control, an acceptance criterion for the subtotal of unspecifi ed impurities has been added.Dipivefrine hydrochloride (1719)The following changes have been made:— an increase in the amount of concentrated ammonia solution used in the mobile phase to improve the symmetry of the peaks;— the introduction of a higher upper limit for the symmetry factor in the assay, i.e. 2.0 for the principal peak in the chromatogram obtained with referencesolution (c).Evening primrose oil, refi ned (2104)The unsaponifi able matter is largely composed of natural vitamins. It is therefore desirable that the oil is smoothly refi ned so that the unsaponifi able matter remains rather high. Based on batch data, the limit for unsaponifi able matter has been increased from 2.0 per cent to 2.5 per cent. Gemfi brozil (1694)Following a study in the EDQM laboratory, method C has been replaced by method F in the test for heavy metals. Furthermore, impurity D has been corrected.Glutathione (1670)Following the establishment of the CRS for glutathione, several batches have been tested and it appeared that the limits for impurity D and for the total of impurities were too strict. These 2 limits have therefore been increased. Human coagulation factor XI (1644)This monograph has been revised to harmonise thetotal protein test with other monographs. Reference to general chapter 2.5.33 is not appropriate since 7 different methods are described and it has not been shown that these 7 methods are equivalent. Since the determination of nitrogen by sulphuric acid digestion (Kjeldahl method) is the only method that can be performed without using a reference preparation, this is the method of choice. Indeed, this is a big advantage since results obtainedcan be compared directly. Other methods can also be used provided that they have been validated against the determination of nitrogen by the sulphuric acid digestion method described in the monograph.Ketorolac trometamol (1755)Following a study in the EDQM laboratory, method C has been replaced by method F in the test for heavy metals. Lauroyl macrogolglycerides (1231)Linoleoyl macrogolglycerides (1232)By analogy with the revision made to the monograph Stearoyl macrogolglycerides (1268) in 2004, the conditions used for the test for free glycerol have been modifi ed.Macrogol 20 glycerol monostearate (2044)In the test for hydroxyl value the method has been changed: method A yields better results, within the limits of 65 to 85.Methadone hydrochloride (0408)The silver nitrate titration in the assay has been replaced by the acid-base titration, which is more specifi c as it determines the active moiety; in addition, the titrant is low-cost, odourless, and easy to handle. This titration has been shown to be equivalent to the silver nitrate titration and to the previous perchloric acid titration.Oleoyl macrogolglycerides (1249)By analogy with the revision made to the monograph stearoyl macrogolglycerides (1268) in 2004, the conditions used for the test for free glycerol have been modifi ed.^_^ ---Pancuronium bromide (0681)2 new impurities have been added to the transparency list. Pancuronium bromide and its impurities cannot be analysed by LC because of insuffi cient sensitivity(little or no chromophores). For this reason, the current TLC method has been optimised to allow detection of impurities at 0.1 per cent.Sucrose (0204)As the amount of lead in the test solution is in practice extremely low, the system suitability criterion in the test for lead has been changed.Sumatriptan succinate (1573)As it is diffi cult to obtain samples of the individualimpurities to prepare replacement CRS batches, a method has been developed based on the injection of mixtures of sumatriptan with impurities obtained by evaporation, to identify the specifi ed impurities in the test for impurity A and impurity H and in the test for related substances.NEW : PHARMEUROPA SCIENTIFIC NOTESFor prices and ordering information please consult the catalogue on our internet site • Few Bicyclic Acetals at Reducing End of Low-Molecular-Weight Heparins: Might they Restrict Specifi cation of Pharmacopoeia?• The Control of Impurities in Chlortalidone Using a Reversed-Phase Stationary Phase • Factor VIII Test in Reference Preparations: Compensation for Different Dilutions • The Control of Impurities in Amitriptyline Hydrochloride Using a Reversed-Phase Hybrid Stationary Phase• A Precise Colour Determination Method for Tablets - an Application of Instrumental Colour Measurement in the Pharmaceutical Development• Development of an in vivo Test Procedure for the Ease of Breaking of Scored Tablets• Chromogenic Assay of Human Coagulation Factor VIII: Statistical Comparison of 2 Working Dilution Procedures• Impurity Profile of Amino Acids?• Batch Variability of Bacitracin: HPLC versus MEKC • Quality Criteria of Homoeopathic Mother Tinctures: Considerations Regarding Suitable Tests for Homoeopathic Monographs • Instructions for Authors Available now (English only)As from Pharmeuropa 17.4, Scientifi c Notes are principally published in a new publication called Pharmeuropa Scientifi c Notes.Articles published in Pharmeuropa Scientifi c Notes are indexed in the PubMed database of the National Library of Medecine, available on the internet site ().The fi rst edition of Pharmeuropa Scientifi c Notes (Pharmeuropa SN 2005-1) became available in August 2005.This issue is included in the subscription to Pharmeuropa, and is not available separately.SCIENTIFIC NOTES 2005-1________________________________________________________________________________^_^---。
ICD疾病编码规则
***医院疾病分类规则汇编———根据英文版ICD-10编码规则翻译改编目录CHAPTER I 某些传染病和寄生虫病(A00—B99) (3)CHAPTER II 肿瘤(COO—D48) (4)CHAPTER III 血液与造血器官疾病和某些涉与免疫机制的疾患(D50—D89) (6)CHAPTER IV 内分泌、营养和代谢疾病(E00—E90) (7)CHAPTER V 精神和行为障碍(F00 —F99) (8)CHAPTER VI 精神系统疾病(G00—G99 ) (10)CHAPTER VII 眼和附器疾病(H00—H59) (12)CHAPTER VIII 耳和乳突疾病 (14)CHAPTER IX 循环系统(I00—I99) (15)CHAPTER X 呼吸系统疾病(J00—J99) (20)CHAPTER XI 消化系统疾病(K00—K93) (22)CHAPTER XII 皮肤和皮下组织疾病(L00—L99) (26)CHAPTER XIII 肌肉骨骼系统和结缔组织疾病(M00—M99) . 28CHAPTER XIV 生殖系统疾病(N00—N99) (32)CHAPTER XV 妊娠、分娩和产褥期疾患(O00—O99) (35)CHAPTER XVI 起源于围生期的某些情况(P00—P96) (40)CHAPTER XVII 先天性畸形、变形和染色体异常(Q00—Q99) (42)CHAPTER XVIII 症状、体征、临床和实验室检查的异常发现,不可分类于他处者(R00—R99) (43)CHAPTER ⅩⅨS00-T98 损伤、中毒和外因的某些其它后果 (45)CHAPTER XX 疾病和死亡的外因V01-Y98 (52)CHAPTER XXI 影响健康状态和与保健机构接触的因素(Z00—Z99) (55)笔记 (57)注:特殊组合章 (61)Chapter I 某些传染病与寄生虫病(A00—B99)1、该章是典型的特殊组合章,因为它并不局限地集中于任何一个身体系统。
热恋至上(三)
热恋至上(三)钟晚眼圈发红,身子颤抖得厉害,她慢慢地、一颗颗地解开衬衣的扣子。
她想,她应该是真的很爱秦盛。
男人面色很冷,里面黑色衬衫的扣子一丝不苟地扣到最上面一颗。
他皱着眉,走到钟晚面前。
“是钟小姐吗?”钟晚点点头,问:“您是哪位?”男人看了姜瑜一眼,淡淡地开口:“姜瑜是我太太。
”“是。
韩先生?”韩致轻轻点头,弯腰抱起姜瑜,道:“辛苦钟小姐了。
”“等一下。
”钟晚沉声开口,她看了韩致一眼,微微垂眸,“姜瑜虽然娇气,但性子直率,若是韩先生对这段婚姻没兴趣的话,还请早日放姜瑜离开。
”韩致皱了皱眉,问道:“钟小姐这话是什么意思?”“婚姻过错方是要净身出户的。
”钟晚礼貌地微笑,“我想韩先生也不想闹到法庭上。
”“是误会,我会和阿瑜解释清楚。
”韩致声音微冷,“阿瑜喝醉了,我得带她回家,钟小姐能让开了吗?”钟晚静静地看了他一眼,侧了下身。
她一直看着韩致抱着姜瑜走远。
期间,韩致低下头,似乎用鼻尖碰了碰姜瑜,看上去亲昵至极。
钟晚叹了口气,心想,但愿只是误会吧。
钟晚寒假没回家,她把行李都搬到秦盛的出租屋里,睡在了那张有些狭窄的床上。
出租屋不大,甚至有些狭小。
客厅只有一张沙发,厨房和客厅是连在一起的,其实也不算是厨房,只是在客厅的一个角落里放了锅碗瓢盆。
卧室更简陋了,除了床,就剩下一张有些破旧的木头桌子,之前上面摆放的是杂物,现在堆着钟晚的书。
钟晚不知道在哪儿买了一小盆仙人掌摆在客厅里,好歹也算个绿植,被她照顾得仔仔细细的。
秦盛曾不止一次嘲笑她:“人家都种花,就你特殊,非种仙人掌。
”钟晚歪着头笑了,道:“仙人掌和我一样,好养活,只要浇水就能长大。
”秦盛挑了下眉,勾起嘴角,笑得有些邪气:“说得对。
”钟晚没急着出去打工,她安安心心地住下,每天起得早,趁着秦盛去修理铺之前煮一锅粥出来,还让他给于哥和黄毛各带一碗。
傍晚的时候她会去菜市场买菜,这个点菜市场的菜都打折处理,一块钱就能买一把青菜。
秦盛晚上回来的时候,就看到狭小的屋子里热气腾腾,钟晚腰上围着围裙在厨房里给他做饭。
拜谨芬(Rylaze)产品说明书
Rylaze™ (asparaginase Erwinia chrysanthemi (recombinant)-rywn) (Intramuscular)-E-Document Number: IC-0655 Last Review Date: 12/01/2022Date of Origin: 02/01/2022Dates Reviewed: 02/2022, 05/2022, 12/2022I.Length of AuthorizationCoverage will be provided for 6 months and may be renewed.II.Dosing LimitsA.Quantity Limit (max daily dose) [NDC Unit]:•Rylaze 10 mg/0.5 mL solution in a single-dose vial: 25 vials per 7 daysB.Max Units (per dose and over time) [HCPCS Unit]:•2,500 billable units (250 mg) per weekIII.Initial Approval Criteria 1Coverage is provided in the following conditions:•Patient is at least 1 month of age; ANDUniversal Criteria 1•Patient must not have a history of serious pancreatitis, thrombosis, or hemorrhagic events with prior L-asparaginase therapy; AND•Used as a component of multi-agent chemotherapy; ANDAcute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) † Ф1-3,5•Used as a substitute for E. coli-derived asparaginase (e.g., pegaspargase) in cases of hypersensitivity (e.g., systemic allergic reactions or anaphylaxis) §§ Definition of Hypersensitivity Reactions (CTCAE v5.0) 7,8Allergic Reaction−Grade 1: Systemic intervention not indicated−Grade 2: Oral intervention indicated−Grade 3: Bronchospasm; hospitalization for clinical sequelae; IV intervention indicated−Grade 4: Life-threatening consequences; urgent intervention indicated−Grade 5: DeathAnaphylaxis−Grade 1 or 2: N/A−Grade 3: Symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated;allergy-related edema/angioedema; hypotension−Grade 4: Life-threatening consequences; urgent intervention indicated−Grade 5: DeathPreferred therapies and recommendations are determined by review of clinical evidence. NCCNcategory of recommendation is taken into account as a component of this review. Regimens deemedequally efficacious (i.e., those having the same NCCN categorization) are considered to betherapeutically equivalent.† FDA Approved Indication(s); ‡ Compendia recommended indication(s); Ф Orphan DrugIV.Renewal Criteria 1Coverage can be renewed based upon the following criteria:•Patient continues to meet universal and other indication-specific relevant criteria such as concomitant therapy requirements (not including prerequisite therapy), performancestatus, etc.identified in section III; AND•Disease stabilization or improvement as evidenced by a complete response [CR] (i.e., morphologic, cytogenetic or molecular complete response CR), complete hematologicresponse or a partial response by CBC, bone marrow cytogenic analysis, QPCR, or FISH;AND•Absence of unacceptable toxicity from the drug. Examples of unacceptable toxicity include:severe hypersensitivity reactions including anaphylaxis, pancreatitis, thrombosis,hemorrhage, hepatotoxicity, etc.V.Dosage/Administration 1All Indications When replacing a long-acting asparaginase product, there are two Rylaze regimens that can be used. (See table below for duration of administration as a replacement therapy).•Rylaze 25 mg/m2 administered intramuscularly every 48 hours; OR •Rylaze 25 mg/m2 administered intramuscularly on Monday and Wednesday morning, and 50 mg/m2 on Friday afternoon (Administer the Friday afternoon dose 53 to 58 hours after the Wednesday morning dose (e.g., 8:00 am on Monday and Wednesday, and 1:00 pm to 6:00 pm on Friday)RYLAZE™ -E- (asparaginase erwinia chrysanthemi recombinant-When RYLAZE is Administered: Recommended Duration ofRYLAZE to ReplaceCalaspargase Pegol ProductsRecommended Duration ofRYLAZE to ReplacePegaspargase Products25 mg/m2 intramuscular every 48 hours Replace one dose ofcalaspargase pegol productswith 11 doses of RYLAZEReplace one dose ofpegaspargase products with7 doses of RYLAZE25 mg/m2 intramuscular on Monday morning and Wednesday morning, and 50 mg/m2 intramuscular on Friday afternoon Replace one dose ofcalaspargase pegol productswith 9 doses of RYLAZEReplace one dose ofpegaspargase products with6 doses of RYLAZEVI.Billing Code/Availability InformationHCPCS Code:•J9021 – Injection, asparaginase, recombinant, (rylaze), 0.1 mg; 1 billable unit = 0.1 mgNDC(s):•Rylaze 10 mg/0.5 mL solution in a single-dose vial: 68727-0900-xxVII.References (STANDARD)1.Rylaze [package insert]. Palo Alto, CA; Jazz Pharmaceuticals, Inc.; November 2022.Accessed November 2022.2.Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCNCompendium®) for Asparaginase Erwinia chrysanthemi (recombinant)-rywn. NationalComprehensive Cancer Network, 2022. The NCCN Compendium® is a derivative work ofthe NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®,and NCCN GUIDELINES® are trademarks owned by the National Comprehensive CancerNetwork, Inc. To view the most recent and complete version of the Compendium, go online to . Accessed November 2022.3.Pieters R, Hunger SP, Boos J, et al. L-asparaginase treatment in acute lymphoblasticleukemia: a focus on Erwinia asparaginase. Cancer. 2011 Jan 15; 117(2): 238–249.4.Raetz EA, Salzer WL. Tolerability and Efficacy of L-Asparaginase Therapy in PediatricPatients With Acute Lymphoblastic Leukemia, Journal of Pediatric Hematology/Oncology:October 2010 - Volume 32 - Issue 7 - p 554-563 doi: 10.1097/MPH.0b013e3181e6f0035.Maese L, Rau RE, Raetz EA, et al. A phase II/III study of JZP-458 in patients with acutelymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) who are hypersensitive to E.coli-derived asparaginases. DOI: 10.1200/JCO.2020.38.15_suppl.TPS7568 Journal of Clinical Oncology 38, no. 15_suppl6.Lin T, Hernandez-Illas M, Rey A, Jenkins J, et al. A Randomized Phase I Study to Evaluatethe Safety, Tolerability, and Pharmacokinetics of Recombinant Erwinia Asparaginase (JZP-RYLAZE™ -E- (asparaginase erwinia chrysanthemi recombinant-458) in Healthy Adult Volunteers. Clin Transl Sci. 2021 May;14(3):870-879. doi:10.1111/cts.12947. Epub 2021 Mar 23.7.Stock W, Douer D, DeAngelo DJ, et al. Prevention and management ofasparaginase/pegasparaginase-associated toxicities in adults and older adolescents:recommendations of an expert panel. Leuk Lymphoma 2011:52;2237-2253.mon Terminology Criteria for Adverse Events (CTCAE) v5.0. NIH National CancerInstitute: Division of Cancer Treatment & Diagnosis – Cancer Therapy Evaluation Program.Available at:https:///protocoldevelopment/electronic_applications/ctc.htm#ctc_50VIII.References (ENHANCED)1e.Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) for Acute Lymphoblastic Leukemia. Version 1.2022. NationalComprehensive Cancer Network, 2022. The NCCN Compendium® is a derivative work ofthe NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®,and NCCN GUIDELINES® are trademarks owned by the National Comprehensive CancerNetwork, Inc. To view the most recent and complete version of the Compendium, go onlineto . Accessed November 2022.2e.Vrooman LM, Kirov II, Dreyer ZE, et al. Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children andAdolescents With Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016Feb;63(2):228-33. doi: 10.1002/pbc.25757. Epub 2015 Sep 16.3e.Magellan Health, Magellan Rx Management. Rylaze Clinical Literature Review Analysis.Last updated November 2022. Accessed November 2022.Appendix 1 – Covered Diagnosis CodesC83.50 Lymphoblastic (diffuse) lymphoma, unspecified siteC83.51 Lymphoblastic (diffuse) lymphoma, lymph nodes of head, face, and neckC83.52 Lymphoblastic (diffuse) lymphoma, intrathoracic lymph nodesC83.53 Lymphoblastic (diffuse) lymphoma, intra-abdominal lymph nodesC83.54 Lymphoblastic (diffuse) lymphoma, lymph nodes of axilla and upper limbC83.55 Lymphoblastic (diffuse) lymphoma, lymph nodes of inguinal region and lower limbC83.56 Lymphoblastic (diffuse) lymphoma, intrapelvic lymph nodesC83.57 Lymphoblastic (diffuse) lymphoma, spleenC83.58 Lymphoblastic (diffuse) lymphoma, lymph nodes of multiple sitesC83.59 Lymphoblastic (diffuse) lymphoma, extranodal and solid organ sitesRYLAZE™ -E- (asparaginase erwinia chrysanthemi recombinant-C91.00 Acute lymphoblastic leukemia not having achieved remissionC91.01 Acute lymphoblastic leukemia, in remissionC91.02 Acute lymphoblastic leukemia, in relapseAppendix 2 – Centers for Medicare and Medicaid Services (CMS)Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National Coverage Determination (NCD), Local Coverage Determinations (LCDs), and Local Coverage Articles (LCAs) may exist and compliance with these policies is required where applicable. They can be found at: https:///medicare-coverage-database/search.aspx. Additional indications may be covered at the discretion of the health plan.Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCD/LCA): N/AJurisdiction Applicable State/US Territory ContractorE (1) CA, HI, NV, AS, GU, CNMI Noridian Healthcare Solutions, LLCF (2 & 3) AK, WA, OR, ID, ND, SD, MT, WY, UT, AZ Noridian Healthcare Solutions, LLC5 KS, NE, IA, MO Wisconsin Physicians Service Insurance Corp (WPS)6 MN, WI, IL National Government Services, Inc. (NGS)H (4 & 7) LA, AR, MS, TX, OK, CO, NM Novitas Solutions, Inc.8 MI, IN Wisconsin Physicians Service Insurance Corp (WPS) N (9) FL, PR, VI First Coast Service Options, Inc.J (10) TN, GA, AL Palmetto GBA, LLCM (11) NC, SC, WV, VA (excluding below) Palmetto GBA, LLCL (12) DE, MD, PA, NJ, DC (includes Arlington &Novitas Solutions, Inc.Fairfax counties and the city of Alexandria in VA)K (13 & 14) NY, CT, MA, RI, VT, ME, NH National Government Services, Inc. (NGS)15 KY, OH CGS Administrators, LLCRYLAZE™ -E- (asparaginase erwinia chrysanthemi recombinant-。
药物分析的基本任务
两人一路无话,很快就来到电梯口,时浅就站在他身边,拿着手机给人回复微信,垂头的姿势使她暴露一截莹白如玉的颈项。
她眨着眼睛,卷翘的睫毛上下鼓动,不笑的时分,眉眼间蕴着清凉的神-韵。 从电梯反光的镜面,能看到隋谨知眸色渐深,安静地凝视着身边的女孩。 刹那,时浅像是察觉到什么,视界从手机上挪开,但隋谨知现已飞快地移开了目光,仅仅唇边留有一抹浅淡的笑意。 “……怎么了?”她问。
6
二、药品检验工作的程序
取样 鉴别
❷ 性状观测 ❶ 留样
检查
❸
含量测定
❹
记录、判断结果,出具检验报告书
7
❶ ❷
❸
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• Quality Improvement • Cost Reduction • Lead Time Reduction • Delivery/Service Improvement • Technology Gain • Shortened Concept-to-Customer Cycle
• Improved supplier cost productivity
• Committed volumes to allow supplier investment
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Procurement Initiative Marketing Response
Purchaser
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-11
Volume Consolidation/Supply Base Optimization (Buy for Less)
• Increased supplier fixed cost utilization • Capitalize on competitive supply base
5-5
Importance of Sourcing
• In the average manufacturing firm purchased goods and services account for 55% of every sales Dollar
• Direct labor costs account for only about 10% of the sales dollar
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-12
Supplier-buyer Integration/ Linked Cost Minimization (Buy Better)
• Improved coordination/forecast accuracy and predictability
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-2
Purchasing vs. Procurement
• Purchasing is normally associated with a functional activity
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-13
Value Management/ Optimization (Consume Better)
• Early supplier involvement in solution design • Reduced complexity/simplified specifications • Increased standardization • Clarified response time objectives • Rationalized requirements • Controlled consumption rates
structure • Leveraged buyer’s share • Enhanced negotiations and contracting
skills
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper. Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
• Procurement/Sourcing should be viewed as a strategic activity for the business.
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-4
92,400,000
55,000,000
Labor
15,000,000
25,200,000
9,600,000
Other
22,000,000
36,960,000
22,000,000
Pre-tax Profit
13,500,000
13,440,000
13,400,000
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-8
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
5-3
Purchasing vs. Sourcing (cont’d)
Purchasing Mentality
One contract at a time Win-lose Immediate returns Secretive Current needs can be met Lowest purchase price Multiple suppliers Infrequent interaction Criticism Buyer-sales relationship Safety in numbers Quality inspected Inventory as safeguard
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
Copyright© 2002 by The McGraw-Hill Companies, Inc. All rights reserved.
Supplier Development Through Procurement
The Marketing Viewpoint
Supplier
Marketing Initiative Purchasing Response
Purchaser
Supplier
McGraw-Hill/Irwin
The Procurement Viewpoint
• Value management/Optimization => “Consume better”
• Sales synergy => “Sell better”
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
SupplyChainLo5-1gisticsManagement
Chapter5:ProcurementandManufactur ingStrategies
McGraw-Hill/Irwin
Supply Chain Logistics Management, First Edition. Bowersox, Closs, and Cooper.
• Optimized logistical flows/value added roles (including outsourcing)
• Streamlined transactional information flow
• Increased and earlier supplier involvement on cost issues