妊娠合并肝功能异常患者临床特征及妊娠结局分析

第36卷第2期2016年4月

健康研究

Health Ｒesearch

Vol．36No．2Apr．2016

收稿日期：2015－05－20

作者简介：谢晓婷（1979－），女，浙江泰顺人，本科，主管技师。

doi ：10．3969/j．issn．1674-6449．2016．02．017

健康科学临床研究

妊娠合并肝功能异常患者临床特征及妊娠结局分析

谢晓婷1，毛凌哲

2

（1．泰顺县罗阳镇中心卫生院检验科，浙江泰顺325500；2．温州康宁医院检验科，浙江温州325000）

摘要：目的探讨妊娠合并肝功能异常患者临床特征及其妊娠结局。方法产检的82例妊娠合并肝功能异常患

者作为肝功能异常组，再随机选择同期健康孕妇的100例作为对照组，分析妊娠肝功能异常患者的病因及妊娠结

局。结果

肝功能异常组妊娠期高血压综合征（Pregnancy induced hypertension syndrome ，PIH ）25例、病毒性肝炎

18例、妊娠期肝内胆汁淤积症（Intrahepatic cholestasis of pregnancy ，ICP ）15例、妊娠剧吐（Hyperemesis gravidarum ，HG ）9例；PIH 、ICP 患者主要发生于妊娠中、晚期，HG 患者主要发生于妊娠早、中期，病毒性肝炎以妊娠晚期为主。肝功能异常组孕妇剖宫产率、产后出血率、胎儿早产率以及胎儿宫内窘迫率均显著高于对照组（P ＜0．05），两组围产儿死亡发生率无显著差异（P ＞0．05）。结论妊娠合并肝功能异常的主要病因为妊娠高血压综合征、病毒性肝

炎、妊娠肝内胆汁淤积症以及妊娠剧吐等，增加母婴不良妊娠结局发生率。

关键词：妊娠；肝功能异常；临床特征；妊娠结局中图分类号：Ｒ563．8

文献标识码：A

文章编号：1674－6449（2016）02－0168－03

An analysis of the clinical characteristics of patients in pregnancy and

with abnormal liver function and the outcomes of pregnancy

XIE Xiao-ting 1，MAO Ling-zhe 2

（1．Clinical Laboratory ，Taishun Luoyang Hospital ，Taishun 325500；2．Clinical Laboratory ，

Wenzhou Kangning Hospital ，Wenzhou 325000，China ）

Abstract ：Objective To investigate the clinical characteristics of patients with pregnancy complicated with abnormal liver function and the outcome of pregnancy．Method 82patients in pregnancy complicated with abnormal liver function were chosen as the experimental group and 100healthy pregnant women were chosen as the control group．Then ，the clinical etiology of abnormal liver function and pregnancy outcomes were analyzed．Findings Of the 82cases of pregnancy with abnormal liver function in patients with disease etiology ，30．49%experienced pregnancy induced hypertension syndrome （PIH ）（25/82）．21．95%experienced viral hepatitis （18/82）．18．29%experienced intrahepatic cholestasis of pregnancy （ICP ）（15/82）．10．96%experienced hyperemesis gravidarum （HG ）（9/82）．PIH ，ICP mainly occurred in the late stage of pregnancy．HG mainly occurred in the early and middle stages of pregnancy while viral hepatitis can occur in any trimester of pregnancy ，yet mainly in the late stage of pregnancy．The cesarean section rate ，postpartum hemorrhage rate ，premature birth rate and fetal distress of the experimental group were higher than those of the control group （P ＜0．05）．No significant difference was found between the two groups in perinatal death rate （P ＞0．05）．Conclusion The disease of pregnancy with abnormal liver function was mainly due to pregnancy induced hypertension syndrome ，viral hepatitis ，pregnancy intrahepatic cholestasis and hyperemesis gravidarum．It gives rise to the incidence adverse pregnancy outcomes．Key words ：pregnancy ；liver function abnormality ；clinical characteristics ；pregnancy outcome