鞠建华博士研究员海洋微生物天然产物及其生物合成学科组

鞠建华博士海洋微生物天然产物及其生物合成学科组组长E-mail: jju@职务描述1. 中国科学院热带海洋生物资源与生态重点实验室主任2. 广东省海洋药物重点实验室主任3. 中国科学院南海海洋研究所研究员，博士生导师个人简介鞠建华，男，1972年生，理学博士，研究员，博士生导师，中国科学院大学岗位教授。

广东省海洋药物重点实验室主任（2010-），中国科学院热带海洋生物资源与生态重点实验室副主任（2010-），海洋微生物天然产物及其生物合成学科组组长。

2014年获得国家杰出青年科学基金、同年入选科技部“创新人才推进计划”中青年科技创新领军人才，2015年入选广东省百千万人才工程领军人才。

主要从事海洋微生物活性次级代谢产物的发现、生物合成和抗感染、抗肿瘤创新药物研发工作，从海洋微生物中发现了具有抗感染、抗肿瘤等活性天然产物500余个，开发了海洋微生物的组合生物合成和异源表达技术，阐明了12种特征活性代谢产物的生物合成机制，揭示了咔啉碱合成酶、Dieckmann缩合酶、细胞色素P450氧化酶等26种新颖生物合成酶的催化功能，筛选出3个自主产权的抗结核杆菌感染、抗胶质瘤和抗白血病候选海洋药物，其中1个在系统临床前研究。

主持国家科技部863计划重点课题、973计划子课题、NSFC-广东联合基金重点项目、国家海洋经济创新发展区域示范专项课题、广东省自然科学基金团队和中科院科技创新交叉团队项目等20余项。

获得第五届施维雅青年药物化学奖(2002)、第七届药明康德生命化学研究奖(2013)。

中国药学会海洋药物专业委员会委员，中国微生物学会海洋微生物专业委员会委员，广东药学会药物化学专业委员会副主任委员，热带海洋学报副主编，中国海洋药物编委，广州市科技创新专家咨询委员会委员，国家自然科学基金委学科会评专家。

在J. Am. Chem. Soc.(IF=12.1)、Angew. Chem. Int. Ed. (IF=11.3)、Org. lett.(6.4)、PNAS、Nature Chem. Biol.、Antimicrob. Agents Chemother.、J. Nat. Prod.、ChemBioChem等国内外学术刊物发表论文121篇（其中SCI论文82篇），论文近5年被引用超过1600次，多篇论文被Nature Chemical Biology, Faculty of 1000, Science-Perspectives和Global Medical Discovery等作为研究亮点评述，被自然指数中国增刊评为2014年广州个体科研产出领先者，获授权专利13项，参与撰写专著3部。

研究兴趣与领域本学科组以海洋微生物为研究对象，以海洋微生物活性次级代谢产物的生物学功能及其形成机制为拟解决的关键科学问题。

主要从特殊海洋环境中（深海沉积物、珊瑚礁生态系统、不同深度的海水层、特色海洋生物等）分离、培养、鉴定海洋放线菌、真菌和细菌；综合运用微生物学、天然产物化学、细菌遗传学、分子生物学、生物信息学、生物化学和药理学等多学科专业技能，从海洋微生物中筛选发现新的生物活性物质，发掘新的生物合成途径、新型酶催化反应机理，利用代谢工程、组合生物合成和合成生物学技术手段构建新结构衍生物，并对具有自主产权、有前景的化合物进行成药性评价和药物开发，具体包括以下内容：(1) 海洋微生物活性次级代谢产物的发现（Marine Bioactive Natural Products Discovery）。

利用化学生态学原理和多种发酵培养技术，从海洋微生物中筛选、分离和鉴定结构新颖、活性显著的生物活性物质。

研究海洋微生物产生的活性物质在特定海洋生态系统中的化学防御机理，发现生理活性显著药效活性物质，为开发具有我国独立知识产权的创新药物提供先导化合物。

(2) 海洋微生物复杂活性天然产物的代谢工程和组合生物合成(Metabolic Engineering and Combinatorial Biosynthesis of Complex Bioactive Natural Products)。

包括：抗生素生物合成基因簇的克隆、序列测定和生物信息学分析；重要活性化合物产生菌全基因组的序列测定及其功能基因研究；新的生物合成途径的发现及其调控机制；基因阻断、置换、重组或异源表达构建工程菌，产生“非天然”的天然产物或提高目标天然产物的产量；利用基因克隆、蛋白表达、纯化手段，对酶促反应机理和动力学进行表征，发掘新型酶促反应催化剂；重要活性天然产物的体外全生物合成(in vitro total biosynthesis)，体外构建重要天然产物的生物合成途径，用生物酶快速合成天然产物衍生物库。

(3) 抗感染、抗肿瘤海洋药物的成药性评价和药物研发(Anti-infective and Anti-tumor Drug Development)。

对通过发现和生物合成技术改造获得的化合物进行构效关系研究，筛选出结构新颖、活性显著、具有自主知识产权的化合物进行体内药效、安全性、质量标准、药代和药剂学等临床前研究，开发抗感染、抗肿瘤海洋药物。

工作经历2008.03—，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，广东省海洋药物重点实验室，研究员，博士生导师，中国科学院大学岗位教授；2003.03—2008.02，美国威斯康星–麦迪逊大学(University of Wisconsin-Madison) 药学院，研究助理(Research Associate)、助理研究员(Assistant Researcher)；2000.08—2003.03，中国医学科学院/北京协和医学院药用植物研究所，助理研究员、副研究员，硕士生导师。

教育背景1995.09—2000.07，北京协和医学院/中国医学科学院，理学博士，天然药物化学专业；1991.09—1995.07，山东大学药学院，理学学士，药学专业。

教授课程研究生课程：生物有机化学，中国科学院大学，北京主要获奖情况1. 2017年获得广东省特支计划“杰出人才”（南粤百杰）称号2. 2016年获得国家“万人计划”科技创新领军人才称号3. 2015年获得广东省特支计划“百千万人才工程领军人才”称号4. 2014年获得“中青年科技创新领军人才”称号5. 国家杰出青年基金获得者（2014年）6. 第七届药明康德生命化学研究学者奖（2013年）7. 第五届施维雅青年药物化学奖(2002)8. 鞠建华,林耕,杨峻山等. 第二届中国科协期刊优秀学术论文奖. 获奖论文：铁破锣皂苷O和P的结构及其药理活性. 药学学报, 2002, 37(10),788-792。

学术任职1. 中国微生物学会海洋微生物专业委员会委员2. 中国药学会海洋药物专业委员会委员3.广东省药学会药物化学专业委员会委员4.《热带海洋学报》副主编5.《中国海洋药物》编委代表性成果论文发表：20181. Li Qinglian+*, Ding Wenjuan, Yao Ziwei., Tu Jiajia, Wang Liyan, HuangHongbo, Li Shengying, Ju Jianhua*. AbmV catalyzes tandem ether installationand hydroxylation during neoabyssomicin/abyssomicin biosynthesis. organicletters. 2018, 20,4854-48572. Qin Xiangjing, Xie Yunchnag, Huang Hongbo, Chen Qi, Ma Junying, Li Qinglian, Ju Jianhua*. Enzymatic synthesis of GDP-b-L-fucofuranose by MtdL and Hyg20. organic letters. 2018, 20,1015-10183. Zhang Chunyan, Yang Zhijie, Qin Xiangjing, Ma Junying, Sun Changli, Huang Hongbo, Li Qinglian, Ju Jianhua*. Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries. organic letters. 2018, 20,7633-76364. Gui Chun, Liu Yena., Zhou Zhen, Zhang Shanwen, Hu Yunfeng, Gu Yucheng, Huang, H.,*. Ju Jianhua*. Angucycline glycosides from mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. Marine Drugs. 2018,16,1855. Li Yan, Zhang Chunyan, Liu Chengxiong, Ju Jianhua,* Ma Junying.* . Genome sequencingof Streptomyces atratus SCSIO ZH16 and activation production of nocardamine via metabolic engineering. Frontiers in Micrbiology. 2018,9,1269-12786. Huang Hongbo., Song Yongxiang, Li Xin, Wang, Xin, Ling Chunyao, Qin Xiangjing, Zhou Zhenbin, Li Qinglian, Wei Xiaoyi, Ju Jianhua*. Abyssomicin monomers and dimers from the marine-derived Streptomyces koyangensis SCSIO 5802. Journal of naturalproducts. 2018, 81,1892-18987. Zhang Chunyan, Sun Changli, Gui Chun, Wang Liyan, Huang Hongbo, Li Qinglian, Ju Jianhua.*. Biosynthetic Baeyer–Villiger chemistry enables access to two anthracene scaffolds from a single gene cluster in deep sea-derived Streptomyces olivaceus SCSIO T05. Journal of natural products. 2018, 81,1570-15778. Gui Chun., Yuan, J., Mo Xuhua, Huang Hongbo, Zhang Shanwen, Gu Yucheng, Ju Jianhua.*. Cytotoxic anthracycline metabolites from a recombinant Streptomyces. Journal of natural products.2018, 81,1278-12899. Sun Jianbin, Shao Junli, Song Yongxiang, Sun Changli, Li Qinglian, Lu Laichun, Hu Yunfeng, Zhang Hua,* Ju Jianhua.* . Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. Bioorganic & Medicinal Chemistry. 2018,26,1488-149410. Sun Changli, Zhang Chunyan., Qin Xiangjing., Wei Xiaoyi, Liu Qing, Li Qinglian, Ju Jianhua*. Genome mining of Streptomyces olivaceus SCSIO T05: discovery of olimycins A andB and assignment of absolute configurations.Tetrahedron. 2018, 74,199-20311. Zhang Shanwen, Gui Chun, Shao Mingwei., Kumar, Saravana, Huang Hongbo,* Ju Jianhua.*. Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077. Natural Product Research. doi:10,1080/14786419,2018,149373620171. Zhu, Q.; Chen, Q.; Song, Y.; Huang, H.; Li, J.; Ma, J.; Li, Q.; Ju, J.* Deciphering the sugarbiosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 4948-4953.2. Ma, J.;* Huang, H.; Xie, Y.; Liu, Z.; Zhao, J.; Zhang, C.; Jia, Y.; Zhang, Y.; Zhang, H.; Zhang,T.; Ju, J.* Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat. Commun.2017, 8(1), 391(doi: 10.1038/s41467-017-00419-5).3. Gui, C.; Mo, X.; Gu, Y.-C.; Ju, J.* Elucidating the sugar tailoring steps in the cytorhodinbiosynthetic pathway. Org. Lett. 2017, 19, 5617-5620.4. Gui, C.; Zhang, S.; Zhu, X.; Ding, W.; Huang, H.; Gu, Y.C.; Duan, Y.; Ju, J.* Antimicrobialspirotetronate metabolites from marine-derived Micromonospora harpali SCSIO GJ089. J.Nat. Prod. 2017, 80, 1594-1603.5. Luo, M.; Cui, Z.; Huang, H.; Song,X.; Sun, A.; Dang, Y.; Lu, L*; Ju, J.* Amino AcidConjugated Anthraquinones from the Marine-derived Fungus Penicillium sp. SCSIO sof101.J. Nat. Prod. 2017, 80, 1668-1673.6. Xie, Y.; Ma, J.; Qin, X.; Li, Q.; Ju, J.* Identification and utilization of two importanttransporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis. Microb. Cell Fact.2017, 16(1):177 (doi:10.1186/s12934-017-0792-8).7. Song, Y.; Li, Q.; Qin, F.; Sun, C.; Liang, H.; Wei, X.; Wong, N.-K.; Ye, L.; Zhang, Y.; Shao,M.; Ju, J.* Neoabyssomicins A–C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802. Tetrohedron, 2017, 73, 5366-5372.8. Chen. E; Chen, Q.; Chen, S.; Xu, B.; Ju, J.*; Wang, H.* Discovery and biosynthesis ofmathermycin from marine-derived Marinactinospora thermotolerans SCSIO 00652. Appl.Environ. Microbiol. 2017, 83(15), pii: e00926-17 (doi: 10.1128/AEM.00926-17).9. Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W.* Discovery of antimycin-type depsipeptides froma wbl gene mutant strain of deep sea-derived Streptomyces somaliensis SCSIO ZH66 andtheir effects on pro-inflammatory cytokine production. Front Microbiol. 2017, 8, 678.10. Zhu, X.; Duan, Y.; Cui, Z.; Wang, Z.; Li, Z.; Zhang, Y.; Ju, J.; Huang, H.* Cytotoxicrearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. J. Antibiot. 2017, 70, 819-822.11. Mo, X.*; Shi, C.; Gui, C.; Zhang, Y.; Ju, J.; Wang, Q.* Identification of nocamycinbiosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb. Cell Fact. 2017, 16(1):100.12. Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I？-？K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2017, doi: 10.1055/s-0043-119888.13. Li, X.; Xia, Z.; Tang, J.; Wu, J.; Tong, J.; Li, M.; Ju, J.; Chen, H.; Wang, L.* Identificationand biological evaluation of secondary metabolites from marine derived fungi-Aspergillus sp.SCSIOW3, cultivated in the presence of epigenetic modifying agents. Molecules,2017, 22(8), pii: E1302 (doi: 10.3390/molecules22081302).201614. Li, Q.; Qin, X.; Liu, J.; Gui, C.; Wang, B.; Li, J.; Ju, J.* Deciphering the biosynthetic originof L-allo-isoleucine.J. Am. Chem. Soc. 2016, 138, 408-415 (Highlighted in JACS Spotlights, 2016, 138, 461; Hot off the Press in Natural Products Reports, 2016, 33, 530)15. Luo, M.; Tang, G.; Ju, J.; Lu, L.; Huang, H.* A new diketopiperazine derivative from a deepsea-derived Streptomyces sp. SCSIO 04496.Nat. Prod. Res. 2016, 30, 138-143.201516. Liu, J.; Wang, B.; Li, H.; Xie, Y.; Li, Q.; Qin, X.; Zhang, X.; Ju, J.* Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries. Org. Lett. 2015, 17, 1509-1512 (Hot off the Press in Natural Product Reports).17. Gui, C.; Li, Q.; Mo, X.; Qin, X.; Ma, J; Ju, J.*Discovery of a new family of Dieckmanncyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org.Lett. 2015, 17, 628-631.18. Li, Q,; Song,X.; Qin, X,; Zhang, X.; Sun, A.; Ju, J.* Identification of the biosynthetic genecluster for the anti-infective desotamides and production of a new analogue in a heterologous host. 2015, J. Nat. Prod.2015, 78, 944-948.19. Song, Y.; Liu, G.; Li, J.; Huang, H.; Zhang, X.; Zhang, H.,* Ju, J.*Cytotoxic andantibacterial angucycline- and prodigiosin- analogues from the deep-sea derived Streptomyces sp. SCSIO 11594. Mar. Drugs, 2015, 13, 1304-1316.20. Medema, M.H.; et al; Xie, Y.; et al; Ju, J.; et al, Gl？ckner, F.O.* Minimum Informationabout a Biosynthetic Gene cluster. Nat. Chem. Biol. 2015, 11, 625-631.21. Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, LohmanJR, Tang GL, Ju J, Liu T, Wilding G, Shen B.* Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc. Natl. Acad. Sci. USA. 2015, 112, 8278-8283.22. Zhang, Y.; Huang, H.; Xu, S.; Wang, B.; Ju, J; Tan, H.; Li, W.* Activation and enhancementof fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology. Microb. Cell Fact. 2015, 14, 64.201423. Song,Y.; Li,Q.; Liu, X.; Chen, Y.; Zhang, Y.; Sun, A.; Zhang, W.; Zhang, J.; Ju, J.* Cyclichexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. J. Nat. Prod.2014, 77, 1937-1941.24. Xie, Y.; Li, Q.; Song, Y.; Ma, J.; Ju, J* Involvement of SgvP in carbon–sulfur bond formationduring griseoviridin biosynthesis.ChemBioChem,2014, 15, 1183-1189 (commented by Faculty of 1000).25. Ji C.,Chen Q., Li Q.,Huang H., Song Y.,Ma J, Ju J.*Chemoenzymatic synthesis of new β-carboline derivatives using McbA, an ATP-dependent amide synthetase. Tetrahedron Lett.2014, 55, 4901-4904.26. Mo X.,Li Q., Ju J.*Naturally occurring tetramic acid products: isolation, structureelucidation and biological activity. RSC Advances. 2014, 4, 50566-50593.27. Zhou X., Huang H.,Li J., Song Y., Jiang R., Liu J., Zhang S., Hua Y.,* Ju J.* New anti-infective cycloheptadepsipeptide congeners and absolute stereo-chemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. Tetrehedron, 2014, 70, 7795-7801.28. Seo, J.W.; Ma, M.; Kwong, T.; Ju, J.; Lim, S.K.; Jiang, H.; Lohman, J.R.; Yang, C.;Cleveland, J.; Zazopoulos, E.; Farnet, C.M.; Shen, B.* Comparative characterization of thelactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 2014, 53(49):7854-7865.29. Wang, H.; Zhang, H.; Mi, Y.; Ju, J.; Chen, Q.; Zhang, H.* Expression, crystallization andpreliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis. Acta Crystallogr F Struct Biol Commun. 2014, 70(Pt 10), 1402-145.201330. Chen, Q.; Ji, C.; Song, Y.; Huang, H.; Ma, J.; Tian, Xi.; Ju, J* Discovery of McbB, a novelenzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew. Chem. Int. Ed., 2013, 52, 9980-9984 (commented by Faculty of 1000). 31. Zhang, Y.; Huang, H.; Chen, Q.; Luo, M.; Sun, A.; Song, Y.; Ma,J.; Ju, J.* Identification ofthe grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org. Lett. 2013, 15, 3254-3257.32. Wang, B.; Song, Y.; Luo, M.; Chen, Q.; Ma, J.; Huang, H.; Ju, J.*Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org. Lett. 2013, 15, 1278-1281.33. Song, Y.; Huang, H.; Chen, Y.; Ding, J.; Zhang, Y.; Sun, A.; Zhang, W.; Ju, J.* Cytotoxic andantibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. J. Nat. Prod. 2013, 76, 2263-2268.34. Zhang, Y.; Zhou, X.; Huang, H.; Tian, X.; Song, Y.; Zhang, S.; Ju, J.*03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. J. Antibiot. 2013, 66, 327-331.35. Zhang, H.; Chen, J.; Wang, H.; Xie, Y.; Ju, J.; Yan, Y.; Zhang, H.* Structural analysis ofHmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Lett. 2013, 587, 1675-1680.36. Ma, M.; Kwong, T.; Lim, S.-K.; Ju, J.; Lohman, J. R.; Shen, B.* Post-polyketide synthasesteps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate speci？city. J. Am. Chem. Soc., 2013, 135, 2489-2492.201237. Mo, X.; Ma, J.; Huang, H.; Wang, B.; Song, Y.; Zhang, S.; Zhang, C.; Ju, J.*11,12-doublebond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycosidehydrolase family enzyme. J. Am. Chem. Soc.2012, 34, 2844-2847 (highlighted in Nat.Chem. Biol. 2012, 8, 320).38. Zhu,Q.; Li, J.; Ma, J.;Luo, M.;Wang, B.; Huang, H.; Tian, X.; Li, W.; Zhang, S.; Zhang, C.;Ju, J.*Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652.Antimicrob. Agents. Chemother.2012, 56, 110-114.39. Xie, Y.; Wang, B.; Liu,J.; Zhou,J.; Ma,J.; Huang, H.; Ju, J.* Identification of the biosyntheticgene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis.ChemBioChem, 2012, 13, 2745-2757 (highlighted as an an inside cover).40. Ma, J.; Zuo, D.; Song, Y.; Huang, H.; Yao, Y.; Li, W.; Zhang, C.; Ju, J.* Characterization of asingle gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13, 547-552.41. Huang, H.; Yang, T.; Ren, X.; Liu, J.; Song,Y.; Sun, A.; Ma, J.; Zhang, Y.; Huang, C.; Zhang,C.; Ju, J.*Cytotoxic angucycline class glycosides from the deep sea actinomyceteStreptomyces lusitanus SCSIO LR32. J. Nat. Prod.2012, 75, 202-208.42. Chen, Z.; Song, Y.; Chen, Y.; Huang, H.; Zhang, W.; Ju, J.*Cyclic heptapeptides,codyheptapeptides C–E, from marine-derived fungus Acremonium persicinum SCSIO 115. J.Nat. Prod., 2012, 75, 1215-1219.43. Huang, H.; Wang, F.; Luo, M.; Chen, Y.; Song, Y.; Wang, B.; Ma, J.; Zhang, W.; Zhang, S.;Ju, J.*Halogenated anthranquinones from the deep sea-derived fungus Aspergillus sp.SCSIO F063. 2012, J. Nat Prod.75, 1346-1352.44. Zhou,X.; Huang, H.; Chen, Y.; Tan, J.; Song,Y.; Zou, J.; Tian, X.; Hua, Y.; Ju, J.*Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60-L scale fermentation of the deep sea-derived marinactinospora thermotolerans SCSIO 00652. J.Nat Prod.2012, 75, 2251-2255.45. Chen, Z.; Zheng, Z.; Huang, H.; Song, Y.; Zhang, X.; Ma,J.; Wang, B.; Zhang C.; Ju, J.*Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg. Med. Chem. Lett., 2012, 22, 3332-3335.201146. Ma, J.; Wang, Z.; Huang, H.; Zuo, D.; Luo, M.; Wang, B.; Sun, A.; Cheng, Y.; Zhang, C.; Ju,J.* Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450enzymes involved in the post-tailoring oxidative steps. Angew. Chem. Int. Ed. 2011, 50, 7797-7802 (commented by Faculty of 1000).47. Mo, X.; Huang, H.; Ma, J.; Wang, Z.; Wang, B.; Zhang, S.; Zhang, C.; Ju J.* Characterizationof TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Org. Lett., 2011, 13, 2212-2215.48. Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.;Zhang, S.; Zhang, C.; Ju, J.*Antimalarial -carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J. Nat. Prod.2011, 74, 2122-2127 (highlighted by Global Medical Discovery).49. Mo, X.; Wang, Z.; Wang, B.; Ma, J.; Huang, H.; Tian, X.; Zhang, S.; Zhang, C.; Ju, J.*Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.Biochem. Biophy. Res. Commun., 2011, 406, 341-347.50. Chen, Z.; Huang, H; Chen, Y.; Wang, Z.; Ma, J.; Wang, B.; Zhang, W.; Zhang, C.; Ju,J.*New cytochalasins from the marine-derived fungus Xylaria sp. SCSIO 156. Helv.Chim.Acta.2011, 94, 1671-1676.51. Huang, Y.; Huang, S. X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.* Characterization of the lnmKLMgenes unveiling key intermediates for -alkylation in leinamycin biosynthesis. Org. Lett., 2011, 13, 498-501.Other representative publications：52. Schneider-Poetsch, T.; Ju, J.; Eyler, D. E.; Dang, Y.; Bhat, S.; Merrick, W. C.; Green, R.;Shen, B.; Liu, J. O*. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat. Chem. Biol.2010, 6, 209-217.53. Ju, J.; Rajski, S.R.; Lim S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B.*Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. J. Am. Chem. Soc. 2009, 131, 1370-1371.54. Ju, J.;# Li, W.;# (co-first-author) Yuan, Q.; Peters, N.R.; Hoffmann, F.M., Rajski, S.R.; Osada,H.; Shen, B.* Functional characterization of ttmM unveils new tautomycin analogs andinsight into tautomycin biosynthesis and activity. Org. Lett., 2009, 11, 1639-1642.55. Ju, J.; Rajski, S.R.; Lim, S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B*. Evaluationof new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorg. Med. Chem. Lett. 2008, 18, 5951-5954.56. Kennedy, D.R.; Ju, J.; Shen, B.; Beerman, T.A.* Designer enediynes generate DNA breaks,interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 17632-17637.57. Ju, J.; Seo, J.-W.; Her, Y.; Lim, S.-K; Shen, B*. New lactimidomycin congeners shed insightinto lactimidomycin biosynthesis in Streptomyces amphibiosporus. Org. Lett., 2007, 9, 5183-5186.58. Ju, J.; Lim, S.-K; Jiang, H.; Seo, J.-W.; Her, Y.; Shen, B*. Thermolysis of isomigrastatin andits congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Org. Lett., 2006, 8, 5865-5868.59. Ju, J.; Lim, S.K.; Jiang, H.; Seo, J.W.; Shen, B.* Isomigrastatin congeners from Streptomycesplatensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. J. Am. Chem Soc. 2005, 127, 11930-11931.60. Ju, J.; Lim, S.K.; Jiang, H.; Shen, B.* Migrastatin and dorrigocins are shunt metabolites ofiso-migrastatin. J. Am. Chem. Soc. 2005, 127:1622-1623.61. Ju, J.; Ozanick, S.G.; Shen, B.; Thomas, M.G.* Conversion of (2S)-arginine to (2S, 3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861.ChemBioChem, 2004, 5:1281-1285.62. Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J*. Tu, G.; Ma, L.; Beesiosides A-F, Six newcycloartane triterpene glycosides from Beesia calthaefolia. J. Nat. Prod.,2002, 65, 42-47.63. Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong N.; Zheng, Q. Beesiosides G, H,and J-N, Seven new cycloartane triterpene glycosides from Beesia calthifolia. J. Nat. Prod., 2002, 65, 147-152.64. Ju, J.; Yang, J.; Li, J.; Xiao, P. Cypripediquinone A, a new phenanthraquinone fromCypripedium macranthum (Orchidaceae ). Chin. Chem. Lett.2000, 11(1), 37-38.授权专利：1. 鞠建华，黄洪波，姚月良，等。