肺放射性损伤
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B. Emami (1991)
➢ Acute & Late Radiation Morbidity Scoring System by
EORTC/ RTOG (1983-1992)
➢ LENT SOMA Scales by EORTC/RTOG (1995)
(subjective, objective, management, analytic scale, late effects of radiation on normal tissues )
Introductory Papers
Guest editor's introduction to QUANTEC
An introduction to scientific issues.
Use of normal tissue complication probability models in the clinic
江苏省肿瘤医院
正常组织的放射耐受剂量
（到目前为止采用的标准）
➢ The WHO Handbook for Reporting Results of Cancer
Treatment [M]. Geneva, Switzerland：World Health Organisation, 1979:48
➢ Tolerance of Normal Tissue to Therapeutic Irradiation
江苏省肿瘤医院 Int J. Radiation Oncology Biol. Phys. Vol. 21, pp. 109-122. 1991
江苏省肿瘤医院
28 critical sites of normal tissue. 197 references 1,062 citations, No.1 in ISI Web of Science (Until 2009.2.3. )
江苏省肿瘤医院
ຫໍສະໝຸດ Baidu
90年代前后放射治疗的改变江苏省肿瘤医院
QUANTEC
江苏省肿瘤医院
A kickoff workshop with 57 invited participants from North America and Europe was held in Madison, Wisconsin, in October 2007 with generous financial support from the American Association of Physicists in Medicine and the Board of the American Society for Therapeutic Radiation Oncology.
➢Analytic data (e.g., pulmonary function
tests or blood gas results).
江苏省肿瘤医院
The US National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v3.0 Some 27 items are listed at the website
Tolerance of normal tissue. B. EMAMI et al. I. J. Radiation Oncology . Biol . Phys. May 15, 1991, Volume 21, Number I
SOMA-late effects normal tissu江e苏s省肿瘤医院 (SOMA-LENT) system
Organ-Specific Papers
16 organ specific clinical papers and each article is organized in a consistent format including 10 sections
➢Subjective findings (e.g.,symptoms of
shortness of breath)；
➢Objective findings (e.g.,changes in
respiratory rate)；
➢Management interventions (e.g., the
institution of steroids or oxygen)；
M. BENTZEN et al. QUANTEC: scientific issues. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S3–S9, 2010
QUANTEC
江苏省肿瘤医院
Quantitative Analysis of Normal Tissue Effects in the Clinic
➢ Common Terminology Criteria for Adverse Events
(CTCAE) by NCI (1988), V3 (2006)
➢ PROMIS Patient-Reported Outcomes Measurement
Information System by National Institutes of Health (2004)
江苏省肿瘤医院
QUANTEC的任务
1. 通过现有资料的总结，对于正常组织特定观测终
点(Endpoint)，提供量化的剂量－效应，与剂量 －体积关系。
2. 根据上述剂量－体积的数据与模型的研究结果，
给临床提供合理的毒性分类方法与工作指南。
3. 提出有助于正确估测和减轻急性、晚期放射治疗
副作用的研究方向。
GUEST EDITORS
Lawrence b. Marks, M.D.(北卡罗来纳大学) Randall k. Ten Haken, Ph.D.(密歇根大学)
Associate Guest Editor
Mary K. Martel, PH.D. (MD安德森医院)
Int. J. Radiation Oncology Biol. Phys., 2010年76卷3 Suppl期S1-160页
➢ Acute & Late Radiation Morbidity Scoring System by
EORTC/ RTOG (1983-1992)
➢ LENT SOMA Scales by EORTC/RTOG (1995)
(subjective, objective, management, analytic scale, late effects of radiation on normal tissues )
Introductory Papers
Guest editor's introduction to QUANTEC
An introduction to scientific issues.
Use of normal tissue complication probability models in the clinic
江苏省肿瘤医院
正常组织的放射耐受剂量
（到目前为止采用的标准）
➢ The WHO Handbook for Reporting Results of Cancer
Treatment [M]. Geneva, Switzerland：World Health Organisation, 1979:48
➢ Tolerance of Normal Tissue to Therapeutic Irradiation
江苏省肿瘤医院 Int J. Radiation Oncology Biol. Phys. Vol. 21, pp. 109-122. 1991
江苏省肿瘤医院
28 critical sites of normal tissue. 197 references 1,062 citations, No.1 in ISI Web of Science (Until 2009.2.3. )
江苏省肿瘤医院
ຫໍສະໝຸດ Baidu
90年代前后放射治疗的改变江苏省肿瘤医院
QUANTEC
江苏省肿瘤医院
A kickoff workshop with 57 invited participants from North America and Europe was held in Madison, Wisconsin, in October 2007 with generous financial support from the American Association of Physicists in Medicine and the Board of the American Society for Therapeutic Radiation Oncology.
➢Analytic data (e.g., pulmonary function
tests or blood gas results).
江苏省肿瘤医院
The US National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v3.0 Some 27 items are listed at the website
Tolerance of normal tissue. B. EMAMI et al. I. J. Radiation Oncology . Biol . Phys. May 15, 1991, Volume 21, Number I
SOMA-late effects normal tissu江e苏s省肿瘤医院 (SOMA-LENT) system
Organ-Specific Papers
16 organ specific clinical papers and each article is organized in a consistent format including 10 sections
➢Subjective findings (e.g.,symptoms of
shortness of breath)；
➢Objective findings (e.g.,changes in
respiratory rate)；
➢Management interventions (e.g., the
institution of steroids or oxygen)；
M. BENTZEN et al. QUANTEC: scientific issues. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S3–S9, 2010
QUANTEC
江苏省肿瘤医院
Quantitative Analysis of Normal Tissue Effects in the Clinic
➢ Common Terminology Criteria for Adverse Events
(CTCAE) by NCI (1988), V3 (2006)
➢ PROMIS Patient-Reported Outcomes Measurement
Information System by National Institutes of Health (2004)
江苏省肿瘤医院
QUANTEC的任务
1. 通过现有资料的总结，对于正常组织特定观测终
点(Endpoint)，提供量化的剂量－效应，与剂量 －体积关系。
2. 根据上述剂量－体积的数据与模型的研究结果，
给临床提供合理的毒性分类方法与工作指南。
3. 提出有助于正确估测和减轻急性、晚期放射治疗
副作用的研究方向。
GUEST EDITORS
Lawrence b. Marks, M.D.(北卡罗来纳大学) Randall k. Ten Haken, Ph.D.(密歇根大学)
Associate Guest Editor
Mary K. Martel, PH.D. (MD安德森医院)
Int. J. Radiation Oncology Biol. Phys., 2010年76卷3 Suppl期S1-160页