第五六章多组分反应和串联反应

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♦ Ivar Karl Ugi (1930-2005),
the inventor of the most significant isocyanide based MCRs.
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wenku.baidu.com
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四、多组分反应展望
♦ Hardly a field in organic chemistry has evolved faster over
only a couple of years than MCRs. However, the very large M CR s pace of >10 2 0 is only e x plore d m arginall y.
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Organic Synthesis
第六章 串联反应新进展
串联反应（ 串联反应（Tandem reaction） ） 串级反应(Cascade reaction) 串级反应 多米诺反应(Domino reaction) 多米诺反应 连续反应(Sequential reaction) 连续反应 Tandem reactions, in which multiple reactions are combined into one synthetic operation, have been reported extensively in the synthetic chemistry literature. ...
第五章 Multi-Component Reactions
Multicomponents reactions (MCRs) are those reactions in which three or more reactants come together in a single reaction vessel to form a new product which contains portions of all the components
A+B+C…. Selectivity Atom economy Diversity Convergency
P MCR
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Complexity Productivity
一、多组分反应的历史
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Angew. Chem. Int. Ed. 2003, 42, 3490 Organic Synthesis
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3.周环反应机理 周环反应机理
R6 R4 R1 NH2 R5 R6 R1 N H
R5 R4 R3 R2
+
R2CHO
+
R3
Tetrahedron Lett. 1998, 29, 5855
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4.混合机理 混合机理 自由基和负离子组合
Angew. Chem. Int. Ed. 1998, 37, 152
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三、金属催化的多组分反应
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♦ Future research in the area of MCRs will include the discovery
and design of novel MCRs, combinations of MCRs and traditional reactions, experimental improvements in solid-and liquid-phase, enantio-and diastereo-selective variations, and more and more applications in drug discovery, material science, bioconjugates, and agrochemical compounds.
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Angew. Chem. Int. Ed. 2009, 48, 7064 –7068 Organic Synthesis
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重排反应 自由基反应 Michael加成反应 加成反应 过渡金属催化的反应 Fischer卡宾配合物的反应 卡宾配合物的反应 周环反应 其他反应
二、多组分反应涉及的反应机理 1.离子机理 离子机理
异腈参与的多组分反应大多为离子机理。 异腈参与的多组分反应大多为离子机理。
Angew. Chem. Int. Ed. 1998, 37, 2234 Organic Synthesis
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2.自由基机理 自由基机理
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