间歇性与持续性雄激素阻断治疗晚期前列腺癌疗效比较

56

CHINA MEDICINE AND PHARMACY

2014年4月第4卷第7期

·短篇论著·

间歇性与持续性雄激素阻断治疗

晚期前列腺癌疗效比较

吴 松 赖海标 钟 亮 黄智峰 曾 晔 李 森 赖伟业 郑东祥 刘毅豪 唐荣志 黄新凯

广东省中山市中医院外一科，广东中山 528400

[摘要] 目的 比较间歇性与持续性雄激素阻断治疗晚期前列腺癌的疗效以及治疗产生的副作用。 方法 选

取我科2012年1月~2013年1月收治的晚期前列腺癌患者76例，分为观察组（38例）及对照组（38例）。

观察组38例行间歇性雄激素阻断治疗即药物去势加抗雄激素药物，对照组38例行持续性雄激素阻断治疗

即手术去势加抗雄激素药物。比较两组患者的副反应发生率及治疗后的生活质量。 结果 观察组38例患

者发生潮热症状者13例（34.21％）、乳房胀痛者12例（31.58％）。对照组23例患者发生潮热症状者26例（68.42％）、乳房胀痛者25例（65.79％）。比较两组潮热症状及乳房胀痛的发生率差异均有统计学意义（P＜0.05）。两组患者治疗后，观察组患者在肠道症状、性功能、尿路症状、骨痛、治疗相关症状方面都较对

照组有明显的改善，生活质量大大提高，两组对比差异有统计学意义（P＜0.01）。 结论 间歇性联合雄激素

阻断治疗可以明显降低患者治疗的副作用并且增加治疗后的生活质量，是晚期前列腺癌患者行雄激素阻断

治疗的首选方案。

[关键词] 前列腺癌；问歇性雄激素阻断；持续性雄激素阻断 

[中图分类号] R737.25 [文献标识码] B [文章编号] 2095-0616（2014）07-56-03

Efficacy comparison of intermittent and continuous androgen deprivation therapies for advanced prostate cancer

WU Song LAI Haibiao ZHONG Liang HUANG Zhifeng ZENG Ye LI Sen 

LAI Weiye ZHENG Dongxiang LIU Yihao TANG Rongzhi HUANG Xinkai

First Department of Surgery, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

[Abstract] Objective To compare the efficacy and side effects of intermittent and continuous androgen deprivation therapies in the treatment of advanced prostate cancer. Methods Seventy-six patients with advanced prostate cancer treated in our department from January 2012 to January 2013 were selected and divided into the observation group

(38 patients) and the control group (38 patients). The observation group received intermittent androgen deprivation

therapy, namely medical castration plus anti-androgen drugs; The control group received continuous androgen deprivation therapy, namely surgical castration plus anti-androgen drugs. The incidences of side effects and the post-

treatment quality of life of the two groups were compared. Results In the observation group, 13 patients (34.21%) had hot flash symptom and 12 patients (31.58%) had breast distending pain. In the control group, 23 patients (68.42%) had hot flash symptom and 25 patients (65.79%) had breast distending pain. The two groups were significantly different in the hot flash symptom and the breast distending pain (P＜0.05). After treatment, the observation group improved more significantly than the control group in the intestinal symptoms, sexual function, urinary symptoms, bone pain and treatment-related symptoms and the quality of life improved largely, with statistically significant differences between two groups (P＜0.01). Conclusion Intermittent androgen deprivation therapy can significantly reduce the patients’side effects and increase post-treatment quality of life, which is the first choice of patients with advanced prostate cancer receiving androgen deprivation therapy.

[Key words] Prostate cancer; Intermittent androgen deprivation; Continuous androgen deprivation

前列腺癌（prostate cancer，PCa）是男性恶性肿瘤中致死率十分高的疾病之一，其发病率现在也是呈不断上升趋势。在美国，其年新发病例数约为男性癌症每年新发病例的29％，居所有男性恶性肿瘤的第1位，男性恶性肿瘤致死原因中其占相关死亡总数的9％，居第2位[1-2]。虽然我国前列腺癌的发病率较欧美国家要低，但随着我国人口的不断老龄化和辅助检查水平的不断提升，前列腺癌的发病人数也是在不断上升。但是由于我们对于前列腺癌筛查工作开展比较晚，所以许多患者在确诊时已为