3D ASL脑灌注成像技术临床应用及研究进展
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301 PLAGH
301病例
脑膜瘤
海绵状血管瘤
301 PLAGH
301病例
星形细胞瘤, WHO II 级
星形细胞瘤, WHO III 级
301 PLAGH
301病例
50岁，男性，脑干占位病变，平扫T2与T1加权像
301 PLAGH
DSC灌注
3D ASL
CBF=49
CBF=109
301 PLAGH
MELAS
301病例
脑梗死
Lou X, Ma L, et al. Differential Diagnosis of MELAS and Ischemic Stroke using 3D Pseudocontinuous Arterial Spin Labeling. ISMRM Scientific Meeting, Italy, 2014
PLD = 1.5S PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
1st test (scanner 1)
80
80
80
80
2nd test (scanner 2)
60
60
60
60
40
301 PLAGH
Musiek ES, etc. Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease. Alzheimers Dement. 2012;8:51-9.
301 PLAGH
采用可弥散的示踪剂进行成像的方法 15O-Water PET 放射性损伤、成本高 Xenon CT 放射性损伤、舒适性差 ASL MRI 99Tc-HMPAO SPECT（Microsphere-like tracers）放射性损伤、半定量 采用不可弥散的示踪剂进行成像的方法 CTP DSC MRI
301 PLAGH
Pulsed ASL (PASL) 脉冲式 Continuous ASL (CASL) 连续式 Pseudo-continuous ASL (PCASL) 准连续式
SNR
PASL CASL
ACCURACY
SAR
+ +++
+++ +
+ +++
PCASL
+++
+++
++
301 PLAGH
301医院放射科 娄昕
2014年4月 11日郑州
301 PLAGH
3D ASL技术简介
3D ASL临床应用
3DHale Waihona Puke BaiduASL研究进展
301 PLAGH
采用可弥散的示踪剂进行成像的方法 15O-Water PET Xenon CT ASL MRI 99Tc-HMPAO SPECT（Microsphere-like tracers） 采用不可弥散的示踪剂进行成像的方法 CTP DSC MRI
301 PLAGH
301 PLAGH
301病例
PLD=1.5S
16.56 51.04 42.29 43.12
PLD=2.5S
301 PLAGH
301病例
Lou X, Ma L. Can 3D pCASL be another predictor to evaluate the collateral Perfusion in Patients with severe intracranial arterial stenosis? ISMRM Scientific Meeting, Italy, 2014
301 PLAGH
有很好的一致性 CBF的侧值无明显差异 ASL 更有利于显示治疗后的过度灌注 (luxury perfusion)
Hernandez D a, etc. Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. Stroke. 2012;43:753–8. Wang DJ, etc. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrastenhanced MRI. Stroke. 2012;43:1018–24. Bokkers RPH,etc. Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke. 2012;43:1290–4.
301 PLAGH
脑发育过程中全 脑CBF的变化
脑发育过程中扣
带回和枕叶的变 化
301 PLAGH
ASL技术进行脑灌注成像准确无创
在ASL技术中PCASL序列SNR高，SAR较低
PCASL序列的可重复性好 PCASL序列扫描参数选择中PLD是关键
ASL临床应用范围广泛
301 PLAGH
301病例
51岁，男性，右顶叶占位病变术后，T2WI与DWI
301 PLAGH
术后增强
DSC灌注
301 PLAGH
3D ASL
CBF=85
CBF=41
DSC灌注
301 PLAGH
301病例
49岁男性，右侧肢体力弱
治 疗 前
治 疗 后
301 PLAGH
3D ASL显示溶栓治疗后过度灌注
301 PLAGH
301 PLAGH
3D ASL技术简介
3D ASL临床应用
3D ASL研究进展
301 PLAGH
N=8 healthy volunteers (7M, 1F, 27-41Y) PCASL, BS, 3D spiral FSE 3 Scans on 2 scanners, 10-15 days apart
传统ASL
3D ASL
采用EPI采集，磁敏感伪影
采用FSE采集，有效克服
明显
磁敏感伪影
2D采集，成像范围有限 对运动伪影敏感
3D采集，大范围成像
Spiral采集高效快速，有
效克服运动伪影
图像质量不稳定
图像信噪比明显提高
301 PLAGH
3D ASL技术简介 3D ASL临床应用 3D ASL研究进展
301 PLAGH
Huang DD, Wu B, Shi KN, Ma L Lou X*. Reliability of Threedimensional pseudo-continuous arterial spin labelling MR imaging for measuring visual cortex perfusion on two 3T scanners. PLOS ONE. 2013;8(11):e79471 HuangDD, Lou X*, Ma L, etc. RSNA, 2013, Oral presentation
灌注成像在食物、药物药代动力学方面 的应用 State and trait (phenotype/genotype) effects状态与特质（表型与基因型）效 应对CBF的影响 Perfusion-based fMRI
301 PLAGH
301 PLAGH
40
40
40
3rd test (scanner 1)
20
20
20
20
0
0
0
0
Subject 1
Subject 2
Subject 3
Subject 4
301 PLAGH
Wu B, Lou X*, Wu XH, Ma L. Intra- and inter-scanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spinlabeling MR perfusion on 3T. J Magn Reson Imaging. 2014;39(2):402-9.
301病例
脑膜瘤
海绵状血管瘤
301 PLAGH
301病例
星形细胞瘤, WHO II 级
星形细胞瘤, WHO III 级
301 PLAGH
301病例
50岁，男性，脑干占位病变，平扫T2与T1加权像
301 PLAGH
DSC灌注
3D ASL
CBF=49
CBF=109
301 PLAGH
MELAS
301病例
脑梗死
Lou X, Ma L, et al. Differential Diagnosis of MELAS and Ischemic Stroke using 3D Pseudocontinuous Arterial Spin Labeling. ISMRM Scientific Meeting, Italy, 2014
PLD = 1.5S PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
PLD = 1.5S
PLD = 2.5S
100
1st test (scanner 1)
80
80
80
80
2nd test (scanner 2)
60
60
60
60
40
301 PLAGH
Musiek ES, etc. Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease. Alzheimers Dement. 2012;8:51-9.
301 PLAGH
采用可弥散的示踪剂进行成像的方法 15O-Water PET 放射性损伤、成本高 Xenon CT 放射性损伤、舒适性差 ASL MRI 99Tc-HMPAO SPECT（Microsphere-like tracers）放射性损伤、半定量 采用不可弥散的示踪剂进行成像的方法 CTP DSC MRI
301 PLAGH
Pulsed ASL (PASL) 脉冲式 Continuous ASL (CASL) 连续式 Pseudo-continuous ASL (PCASL) 准连续式
SNR
PASL CASL
ACCURACY
SAR
+ +++
+++ +
+ +++
PCASL
+++
+++
++
301 PLAGH
301医院放射科 娄昕
2014年4月 11日郑州
301 PLAGH
3D ASL技术简介
3D ASL临床应用
3DHale Waihona Puke BaiduASL研究进展
301 PLAGH
采用可弥散的示踪剂进行成像的方法 15O-Water PET Xenon CT ASL MRI 99Tc-HMPAO SPECT（Microsphere-like tracers） 采用不可弥散的示踪剂进行成像的方法 CTP DSC MRI
301 PLAGH
301 PLAGH
301病例
PLD=1.5S
16.56 51.04 42.29 43.12
PLD=2.5S
301 PLAGH
301病例
Lou X, Ma L. Can 3D pCASL be another predictor to evaluate the collateral Perfusion in Patients with severe intracranial arterial stenosis? ISMRM Scientific Meeting, Italy, 2014
301 PLAGH
有很好的一致性 CBF的侧值无明显差异 ASL 更有利于显示治疗后的过度灌注 (luxury perfusion)
Hernandez D a, etc. Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. Stroke. 2012;43:753–8. Wang DJ, etc. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrastenhanced MRI. Stroke. 2012;43:1018–24. Bokkers RPH,etc. Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke. 2012;43:1290–4.
301 PLAGH
脑发育过程中全 脑CBF的变化
脑发育过程中扣
带回和枕叶的变 化
301 PLAGH
ASL技术进行脑灌注成像准确无创
在ASL技术中PCASL序列SNR高，SAR较低
PCASL序列的可重复性好 PCASL序列扫描参数选择中PLD是关键
ASL临床应用范围广泛
301 PLAGH
301病例
51岁，男性，右顶叶占位病变术后，T2WI与DWI
301 PLAGH
术后增强
DSC灌注
301 PLAGH
3D ASL
CBF=85
CBF=41
DSC灌注
301 PLAGH
301病例
49岁男性，右侧肢体力弱
治 疗 前
治 疗 后
301 PLAGH
3D ASL显示溶栓治疗后过度灌注
301 PLAGH
301 PLAGH
3D ASL技术简介
3D ASL临床应用
3D ASL研究进展
301 PLAGH
N=8 healthy volunteers (7M, 1F, 27-41Y) PCASL, BS, 3D spiral FSE 3 Scans on 2 scanners, 10-15 days apart
传统ASL
3D ASL
采用EPI采集，磁敏感伪影
采用FSE采集，有效克服
明显
磁敏感伪影
2D采集，成像范围有限 对运动伪影敏感
3D采集，大范围成像
Spiral采集高效快速，有
效克服运动伪影
图像质量不稳定
图像信噪比明显提高
301 PLAGH
3D ASL技术简介 3D ASL临床应用 3D ASL研究进展
301 PLAGH
Huang DD, Wu B, Shi KN, Ma L Lou X*. Reliability of Threedimensional pseudo-continuous arterial spin labelling MR imaging for measuring visual cortex perfusion on two 3T scanners. PLOS ONE. 2013;8(11):e79471 HuangDD, Lou X*, Ma L, etc. RSNA, 2013, Oral presentation
灌注成像在食物、药物药代动力学方面 的应用 State and trait (phenotype/genotype) effects状态与特质（表型与基因型）效 应对CBF的影响 Perfusion-based fMRI
301 PLAGH
301 PLAGH
40
40
40
3rd test (scanner 1)
20
20
20
20
0
0
0
0
Subject 1
Subject 2
Subject 3
Subject 4
301 PLAGH
Wu B, Lou X*, Wu XH, Ma L. Intra- and inter-scanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spinlabeling MR perfusion on 3T. J Magn Reson Imaging. 2014;39(2):402-9.