新型的CD_4_T细胞_Th17细胞

[8]Grunds tro m S,And ers on P,Scheipers P,et a l.Bcl23and NFkap2

paB p502p50homod i m ers act as transcri pti onal rep ress ors i n tol2

erant CD4+T cells[J].J Bi ol Ch e m,2004,279(9):

846028468.

[9]Y e S,W atts GF,M anda li a S,et al.Preli m i nary report:geneti c vari2

ati on i n t he hum an s tro m el ysi n pro m oter is associat ed w i th p rogers2

si on of coronary at heroscl erosis[J].BrH eart J,1995,73(3):2092

215.

[10]H i rash i k iA,Ya m ada Y,M urase Y,et a l.Associ ati on of gen e po l y2

m orphis m s w i th coronary artery d is ease i n lo w2or h i gh2ris k s ub2

jects defined by conven ti onal ri sk factors[J].J Am Coll Cardio,l

2003,42(8):142921437.

[11]Zh ou X,H uang J,Chen J,et al.H ap l otype anal ys i s of t he m atrix

m etall op rotei nas e23gene and m yocard i al i n farcti on i n a Ch i n ese

H an popu l ati on.Th e Beiji ng A t eroscl erosis Study[J].Thro m b

H ae most,2004,92(4):8672873.

[12]Poll anen PJ,Leh ti m ak iT,M i kkelsson J,et al.M atri xm etall oprotei2

nase3and9gene pro m oter pol ymorph is m s:j oi n t acti on of t w o l oci

as a ris k factor for coronary artery co m p li cated p l aques[J].A t h er2

oscl erosis,2005,180(1):73278.

[13]H oppm ann P,K och W,Schom i g A,et al.The5A/6A pol ymor2

ph is m of the stro m el ys i n21gene and res t en os i s after percu t an eou s

coronary i n terventi on s[J].Eur H eart J,2004,25(4):3352341. [14]Y e S,Gale C R,M artyn C N.Vari ation i n t he m atri x m etalloprotei n2

ase21gen e and ris k of coronary heart disease[J].Eu r H eart J,

2003,24(18):166821671.

[15]H l at ky MA,Ash l ey E,Querter m ou s T,et al.M atrix m etalloprotei n2

ase circu l ati ng l evels,gen eti c pol y m orph i s m s,and suscep ti b ili ty to

acu t e m yocard i al i nfarcti on a m ong patients w it h coronary artery

d isease[J].Am H eart J,2007,154(6):104321051.[16]Y a m ada Y,Iza wa H,Ic h i h ara S,et a l.Pred icti on of t h

e ri sk ofm y2

ocard i al infarcti on from pol y m orph i s m s i n cand i date genes[J].N

Engl J M ed,2002,347(24):191621923.

[17]Samnegard A,Sil vei ra A,Lundman P,et a l.Seru m m atri x m et a ll o2

p rotei nas e23con centrati on i s i n fluenced by MMP2316125A/6A

pro m oter genot ype and as soci ated wit h m yocard i al i n farcti on[J].J

IntM ed,2005,258(5):4112419.

[18]Gn asso A,Motti C,Irace C,et al.G enetic vari ati on i n hum an

stro m elys i n gen e p ro m ot er and co m m on carotid geo m etry in healthy

m ale sub jects[J].A rteri oscl er Th ro m b Vasc Bi o,l2000,20(6):

160021605.

[19]Raura maa R,Va i sanen SB,Luong LA,et a l.Stro m el ys i n21and i n2

terleuk i n26gen e pro m oter po l y m orph is m s are deter m i nan ts of a2

s ymp t o m ati c caroti d artery at h eroscl erosis[J].A rteri oscler Thromb

Vasc Bi o,l2000,20(12):265722662.

[20]Rundek T,E l k i nd MS,P itt m an J,et al.Caroti d i nti m a2m ed i a

thickness i s associ ated wit h all elic vari an ts of s tro m el ysi n21,i n ter2

leuk i n26,and h epatic li pase genes:t h e Northern Manh attan Pro2

s pecti ve Cohort Study[J].Stroke,2002,33(5):142021423. [21]Gh ilardiG,Bi ond iML,D e M on tiM,et al.M atrixm etall op rotei nas e2

1and m atri x m etall op rotei nas e23gen e p ro m ot er pol y m orph i s m s are

associat ed w it h caroti d artery stenosis[J].Stroke,2002,33(10):

240822412.

[22]A r m strong C,Ab illei ra S,Si tzerM,et al.Po l y m orph is m s i n MM P

Fa m il y and TI M P genes and caroti d art ery i n ti m a2m ed ia th i ckness

[J].Stroke,2007,38(11):289522899.

[23]F l ex A,Gaetan i E,Papal eo P,et al.Proi n fla m m atory geneti c pro2

fil es i n sub jects w it h h i story of i sche m i c strok e[J].Stroke,2004,

35(10):227022275.

收稿日期:2008203217修回日期:2008205207

新型的CD4+T细胞:Th17细胞

王国栋,张爱元,邵静波

(潍坊市人民医院心内一科,山东潍坊261041)

中图分类号:R392.11文献标识码:A文章编号:100622084(2008)1722603204

摘要:Th17是近年来发现的一种CD4+T细胞亚型,在自身免疫性疾病中发挥重要的作用,其分泌产生几种致炎细胞因子,包括新发现的细胞因子白细胞介素17。Th17产生的细胞因子与Th1、Th2不同并且与其相互对抗。Th17细胞很可能对防御胞外病原菌的感染及自身免疫性疾病产生影响。影响Th17细胞从T细胞前体分化的因素也很快被发现,本文综述了Th17细胞诱导分化的影响因素、产生的细胞因子、在自身免疫病中的作用。

关键词:C D

4

+T细胞;Th17细胞;白细胞介素17

A N e w Sub s et of CD4+T C ell s:Th17WA NG Gu o2d ong,Z HA NG Ai2yuan,S HAO J i ng2bo.(De part2

m e n t of Card iol ogy,Wei fang P eo p le c s H os pit a l,Wei fang261041,China)

Ab stract:Th17,a novel s ubset of CD4+T cells was i den ti fi ed t hat p l ays a cruci a l ro l e i n i n fla m2 m ation and au t oi m m un e d iseas e,wh ich p roduces s everal proi n fl a mm at ory cytok i n es,i ncl ud i ng t he novel cytok i ne i n t erl euk i n I L217.The cytok i nes produ ced by Th17are d ifferent fro m t hose by Th1or Th2, they are antagon i zed.Th17cells are prob ab l y eff ecti ve i n p rotection agai ns t extracell u lar b acteria,bu t al so p l ay a rol e i n a m p lification of au t o i m m une d i sorders.And t h e factors t hat s pecif y d ifferenti ati on of

I L217producing effect or T cells fro m n ai ve T cell p recu rsors are be i ng rapidly d i scovered.Th is articl e

discussed t h e fact ors on Th17i ndu ced generati on and d ifferenti ation,t he cytok i ne profili ng,the f un cti on of the cell li neage involved i n au t o i m m une d i seases.

K ey word s:CD4+T cel;l Th17cel;l In t erleuk i n217

天然CD4+T细胞是一种具有很多亚群的前体,具

有抗原识别特异性,是主要组织相容性复合物Ò类分子限制性T细胞。根据产生淋巴因子的种类和生物学功能的不同,CD4+T细胞主要分为辅助性T细胞1型(T help ce ll1, Th1)、2型(T help ce ll2,Th2)和调节性T细胞(regulatory T cells,T reg)[1]。Th1型细胞主要产生干扰素C(interferon2C, I FN2C)、白细胞介素2(i n terleu2 k i n22,I L22)和肿瘤坏死因子B (tumor necr osis f actor B,T NF2B),参与细胞免疫和迟发型超敏反应,协助B细胞产生Ig G2,在抗

细胞内微生物感染和细胞免疫所引起的炎性反应中发挥作用。Th2型细胞主要产生I L24、I L25、I L210和