新型的CD_4_T细胞_Th17细胞

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Th17产生的细胞因子与Th1、Th2不同并且与其相互对抗。

Th17细胞很可能对防御胞外病原菌的感染及自身免疫性疾病产生影响。

影响Th17细胞从T细胞前体分化的因素也很快被发现,本文综述了Th17细胞诱导分化的影响因素、产生的细胞因子、在自身免疫病中的作用。

关键词:C D4+T细胞;Th17细胞;白细胞介素17A N e w Sub s et of CD4+T C ell s:Th17WA NG Gu o2d ong,Z HA NG Ai2yuan,S HAO J i ng2bo.(De part2m e n t of Card iol ogy,Wei fang P eo p le c s H os pit a l,Wei fang261041,China)Ab stract:Th17,a novel s ubset of CD4+T cells was i den ti fi ed t hat p l ays a cruci a l ro l e i n i n fla m2 m ation and au t oi m m un e d iseas e,wh ich p roduces s everal proi n fl a mm at ory cytok i n es,i ncl ud i ng t he novel cytok i ne i n t erl euk i n I L217.The cytok i nes produ ced by Th17are d ifferent fro m t hose by Th1or Th2, they are antagon i zed.Th17cells are prob ab l y eff ecti ve i n p rotection agai ns t extracell u lar b acteria,bu t al so p l ay a rol e i n a m p lification of au t o i m m une d i sorders.And t h e factors t hat s pecif y d ifferenti ati on ofI L217producing effect or T cells fro m n ai ve T cell p recu rsors are be i ng rapidly d i scovered.Th is articl ediscussed t h e fact ors on Th17i ndu ced generati on and d ifferenti ation,t he cytok i ne profili ng,the f un cti on of the cell li neage involved i n au t o i m m une d i seases.K ey word s:CD4+T cel;l Th17cel;l In t erleuk i n217天然CD4+T细胞是一种具有很多亚群的前体,具有抗原识别特异性,是主要组织相容性复合物Ò类分子限制性T细胞。