外周血嗜酸粒细胞评估老年危重AECOPD患者治疗效果预后的意义

外周血嗜酸粒细胞评估老年危重AECOPD患者治疗效果预后

的意义

摘要：目的探讨外周血嗜酸粒细胞在评估老年危重AECOPD患者治疗效果及预

后中的应用价值。方法回顾性分析我院2017年6月～2018年5月收治的80例

老年危重AECOPD患者临床资料，依据入院时血常规中的血嗜酸粒细胞百分比（Eos%）将入选患者分为阴性组、（Eos≤2%，n=58）和阳性组（Eos＞2%，

n=22）。分析并比较两组患者临床资料，进一步对生存及死亡患者进行性别、年龄、APACHEⅡ评分、Eos水平、激素使用及有创机械通气使用率等临床资料进行

组间分析、比较。结果阴性组与阳性组患者在性别、年龄、BMI、吸烟史、合并症、APACHEⅡ评分、CRP、血小板、无创通气使用率等指标差异比较上均无统计

学意义（P>0.05），但两组在白细胞指标及有创通气使用率、住院时间及死亡率

等差异比较上均具有统计学意义（P<0.05）。20例死亡组患者与60例生存组患

者在性别、年龄、APACHEⅡ评分等一般资料差异比较上均无统计学意义

（P>0.05）；但两组患者在Eos水平、激素使用、有创通气使用率等差异比较上

均具有统计学意义（P<0.05）。结论嗜酸粒细胞在老年危重AECOPD患者临床治

疗及预后评估中具有重要价值，其中嗜酸粒细胞≤2%患者住院时间较长、有创通

气使用率及死亡率均较高，临床中应对该类患者予以重点关注。

关键词：外周血嗜酸粒细胞；老年危重AECOPD；治疗效果；预后评估

[Abstract] objective to explore the application value of peripheral blood eosinophil in the evaluation of treatment effect and prognosis of senile critical patients with AECOPD. Methods retrospective analysis was performed on the clinical data of 80 critically ill elderly AECOPD patients admitted to our hospital from June 2017 to May 2018. According to the percentage of serum eosinophils（Eos%）in the blood routine

at the time of admission，the enrolled patients were divided into negative group，（Eos≤2%，n=58）and positive group（Eos > 2%，n=22）. Analysis and compare the two groups of patients with clinical data，further to gender，age，life and death in patients with APACHE Ⅱ score and the level of the Eos，hormone use，and invasive mechanical ventilation utilization rate between group analysis and comparison are made on the clinical data. Results negative groups and positive groups in gender，age，BMI，smoking history，complications，APACHE Ⅱ score，CRP，blood platelets，noninvasive ventilation efficiency indicators such as diff on no statistical significance

（P > 0.05），but the two groups in the leucocyte index and invasive ventilation utilization rate，length of hospital stay，and mortality differences such as comparisons were statistically significant（P < 0.05）. 20 deaths patients and 60 patients survival groups in gender，age，APACHE Ⅱ score data difference compared commonly on had no statistical significance（P > 0.05）；However，differences in Eos level，hormone use and invasive ventilation rate between the two groups were statistically significant（P<0.05）. Conclusion eosinophil is of great value in the clinical treatment and prognosis evaluation of elderly critically ill patients with AECOPD，among which the length of hospital stay，invasive ventilation rate and mortality of patients with acidophil less than 2% are relatively high，which should be paid more attention to in clinic.