Bcr-Abl抑制剂_激动剂_MCE

Bcr-Abl
most patients with chronic myelogenous leukemia (CML). More than
90% of CML cases are caused by a chromosomal abnormality that
results in the formation of a so-called Philadelphia chromosome. This
abnormality is a consequence of fusion between the Abelson (Abl)
tyrosine kinase gene at chromosome 9 and the break point cluster
(Bcr) gene at chromosome 22, resulting in a chimeric oncogene
(Bcr-Abl) and a constitutively active Bcr-Abl tyrosine kinase that has
been implicated in the pathogenesis of CML. Compounds have been
developed to selectively inhibit the tyrosine kinase.
Bcr-Abl Inhibitors & Modulators
Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of 1 nM/0.8 nM respectively; also inhibit c-Kit DCC-2036(Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to Flumatinib mesylate (HH-GV-678 mesylate), a derivative of imatinib,is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and GNF-2 is a highly selective non-ATP competitive inhibitor of GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22(plusmn)0.1 uM (Wild type Abl).
Email: sales@
(BMS-354825 hydrochloride; Sprycel hydr
Cat. No.: HY-10181A
Cat. No.: HY-13024
Cat. No.: HY-12070
Cat. No.: HY-13904
Cat. No.: HY-13905
Cat. No.: HY-11007
Cat. No.: HY-15738
Cat. No.: HY-10943
Nilotinib (AMN-107) is a Bcr-Abl inhibitor with IC50 less than 30 nM.
Nilotinib (AMN-107) is a Bcr-Abl inhibitor with IC50 less than 30 nM.
Nocodazole is a rapidly-reversible inhibitor of microtubule
polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K (alpha)/(delta) isoforms PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of
~22 nM for Src, Yes and Abl kinase; less potent for FGFR(alpha) and Radotinib(IY-5511) is a novel and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.
XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora
ZM-306416(CB 676475) is a VEGFR inhibitor that inhibits Flk-1 (KDR)(IC50=100 nM) and Flt (IC50 =2 (mu)M); displays 4-fold selectivity Cat. No.: HY-10159
Cat. No.: HY-10159A
Cat. No.: HY-13520
Cat. No.: HY-12338
Cat. No.: HY-10395
Cat. No.: HY-15728
Cat. No.: HY-15749
Cat. No.: HY-13785。