3D ASL脑灌注成像技术临床应用及研究进展

CBF=41

DSC灌注

301病例

49岁男性，右侧肢体力弱 治 疗 前

治 疗 后

3D ASL显示溶栓治疗后过度灌注

MELAS

301病例

脑梗死

Lou X, Ma L, et al. Differential Diagnosis of MELAS and Ischemic Stroke using 3D Pseudocontinuous Arterial Spin Labeling. ISMRM Scientific Meeting, Italy, 2014

  

Pulsed ASL (PASL) 脉冲式 Continuous ASL (CASL) 连续式 Pseudo-continuous ASL (PCASL) 准连续式
SNR ACCURAC Y SA R

PASL
CASL PCASL

+ +++
+++

+++ +
+++

+ +++
++

传统ASL


 HuangDD, Lou X*, Ma L, etc. RSNA, 2013, Oral presentation

301病例
PLD=1wk.baidu.com5S
16.56 51.04 42.29 43.12

PLD=2.5S

301病例

Lou X, Ma L. Can 3D pCASL be another predictor to evaluate the collateral Perfusion in Patients with severe intracranial arterial stenosis? ISMRM Scientific Meeting, Italy, 2014
脑膜瘤

海绵状血管瘤

301病例
星形细胞瘤, WHO II 级

星形细胞瘤, WHO III 级

301病例

50岁，男性，脑干占位病变，平扫T2与T1加权像

DSC灌注

3D ASL
CBF=49

CBF=109

301病例

51岁，男性，右顶叶占位病变术后，T2WI与DWI

术后增强

DSC灌注

3D ASL

CBF=85

3D ASL技术简介
3D ASL临床应用

3D ASL研究进展

 



N=8 healthy volunteers (7M, 1F, 27-41Y) PCASL, BS, 3D spiral FSE 3 Scans on 2 scanners, 10-15 days apart
PLD = 1.5S PLD = 2.5S

 Huang DD, Wu B, Shi KN, Ma L Lou X*. Reliability of Threedimensional pseudo-continuous arterial spin labelling MR imaging for measuring visual cortex perfusion on two 3T scanners. PLOS ONE. 2013;8(11):e79471





采用可弥散的示踪剂进行成像的方法  15O-Water PET 放射性损伤、成本高  Xenon CT 放射性损伤、舒适性差  ASL MRI 99Tc-HMPAO SPECT（Microsphere-like  tracers）放射性损伤、半定量 采用不可弥散的示踪剂进行成像的方法  CTP  DSC MRI

20

20

20

20

0

0

0

0

Subject 1

Subject 2

Subject 3

Subject 4

Wu B, Lou X*, Wu XH, Ma L. Intra- and inter-scanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spinlabeling MR perfusion on 3T. J Magn Reson Imaging. 2014;39(2):402-9.
100

PLD = 1.5S

PLD = 2.5S
100

PLD = 1.5S

PLD = 2.5S
100

PLD = 1.5S

PLD = 2.5S
100

1st test (scanner 1)

80

80

80

80

2nd test (scanner 2)

60

60

60

60

40

40

40

40

3rd test (scanner 1)
3D ASL技术简介
3D ASL临床应用 3D ASL研究进展





采用可弥散的示踪剂进行成像的方法  15O-Water PET  Xenon CT  ASL MRI 99Tc-HMPAO SPECT（Microsphere-like  tracers） 采用不可弥散的示踪剂进行成像的方法  CTP  DSC MRI


 


有很好的一致性 CBF的侧值无明显差异 ASL 更有利于显示治疗后的过度灌注 (luxury perfusion)
Hernandez D a, etc. Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. Stroke. 2012;43:753–8. Wang DJ, etc. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrastenhanced MRI. Stroke. 2012;43:1018–24. Bokkers RPH,etc. Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke. 2012;43:1290–4.

3D ASL


采用EPI采集，磁敏感伪影 明显

采用FSE采集，有效克服
磁敏感伪影

 

2D采集，成像范围有限 对运动伪影敏感

 

3D采集，大范围成像 Spiral采集高效快速，有 效克服运动伪影

图像质量不稳定

图像信噪比明显提高

3D ASL技术简介 3D ASL临床应用 3D ASL研究进展

301病例