【复旦大学-高级病理生理学学习】_复旦大学-高级病生-血管新生与疾病

Smooth Muscle Cells
Basement Membrane
Endothelium
Prot百度文库ases
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Angiogenesis - Endothelial Cell Migration
VEGF
Smooth Muscle Cells
Basement Membrane
Endothelium
ANGIOGENESIS
Department of Physiology and Pathophysiology, Shanghai Medical College Fudan University
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Outline
1- Angiogenesis and vasculogenesis 2- Important factors, receptors and signaling pathways 3- Tumor angiogenesis 4- Angiogenesis-related diseases
5- Anti-angiogenesis therapies and therapeutic Angiogenesis 6- Angiogenesis assay model
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Angiogenesis and vasculogenesis
Angiogenesis Sprouting or Non-sprouting of cells from mature endothelial cells of the vessel wall
SMC, pericyte recruitment
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Angiogenesis - Vascular Maturation
Smooth Muscle Cells
Basement Membrane
Endothelium
Endothelial cell-cell junctions
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Non-Sprouting Angiogenesis (Intussuseptive angiogenesis)
Nascent Vascular Sprouts
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Angiogenesis - Endothelial Cell Proliferation
VEGF
Smooth Muscle Cells
Basement Membrane
Endothelium
Sprout Elongation
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Angiogenesis - Capillary Morphogenesis
VEGF
Smooth Muscle Cells
Basement Membrane
Endothelium
New Lumen Formation
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Angiogenesis - Vascular Maturation
VEGF
Smooth Muscle Cells
Basement Membrane
Endothelium
Mouse cornea: wounding induces angiogenesis, chemotactic response to angiogenic factors
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Angiogenesis - Basement Membrane Breakdown
Angiogenic Stimulus (VEGF)
Structure of vessels and capillaries
Small artery: Capillary: endothelial cell, basal lamina, pericytes
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Angiogenesis: Sprouting angiogenesis
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Angiogenesis: Sprouting angiogenesis
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Capillary lumen opening up behind the tip cell
(red dye injected)
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Angiogenesis in retina
Normal macular
macular degeneration
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Outline
1- Angiogenesis and vasculogenesis 2- Important factors, receptors and signaling pathways 3- Tumor angiogenesis 4- Angiogenesis-related diseases 5- Anti-angiogenesis therapies and therapeutic Angiogenesis 6- Angiogenesis assay model
Discovery by Napoleone Ferrara and colleagues of possibly the most important
angiogenic factor, VEGF
1Ferrara. Nat Rev Cancer 2002 5 2Folkman. NEJM 1971
Vasculogenesis Formation of blood vessels by differentiation from (hem)angioblasts
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Angiogenesis and vasculogenesis
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Key landmarks in understanding angiogenesis
suggestion that the new vessels have an important pathogenic role in the cancer process1
Landmark publication: Judah Folkman proposes tumour growth is angiogenesis-dependent2
1787
Angiogenesis first described by Dr John Hunter
1990s
1800 1971 1989
Several German pathologists observe that some human tumours are highly vascularised, leading to the
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Normal Angiogenesis in Children
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Normal Angiogenesis in Adults
Angiogenesis in uterine lining
Angiogenesis in tissue during wound healing
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Capillaries sprouting in the retina of an embryonic mouse