低甲状腺摄碘率甲亢的_131_I治疗疗效分析

论著低甲状腺摄碘率甲亢的131I治疗疗效分析

林枫，史育红，颜兵，董延武，陈启

（核工业416医院甲亢专科，四川成都610051）

【摘要】目的探讨甲状腺摄碘率＜30%甲亢患者131I治疗疗效。方法分析甲状腺摄碘率＜30%(实验组)及＞30%(对照组)甲亢患者131I治疗后甲减发生率及甲亢治愈率。结果实验组276例与对照组568例甲亢患者131I治疗后

6个月，治愈率与甲低发生率无明显差异。结论甲亢131I治疗不仅适合甲状腺摄碘率＞30%的甲亢患者，同时适合甲状

腺摄碘率＜30%的甲亢患者。

【关键词】甲亢;131I治疗;甲状腺摄碘率

【中图分类号】R581.1【文献标识码】A【文章编号】1004-0501(2012)12-2127-02

Radioiodine treatment of hyperthyroidism in patients with lowradioiodine thyroid uptake．LIN Feng，SHI Yu-hong，YAN Bing，et al．The Nuclear Industry416Hospital，Chengdu，Sichuan610051，China

【Abstract】Objective To analyze the effectiveness of radioactive131I in hyperthyroid patients with confirmed lower radio-iodine uptake as compared to patients with an uptake of over30%．Methods We analyzed276consecutive hyperthyroid patients

with a maximum iodine uptake of（24.4ʃ5.3）%（range，20 30%）．The control group consisted of568patients treated with131

I with an iodine uptake of over30%．Each patient was evaluated before and6months after treatment．Results By comparison of clinical remission of hyperthyroidism in patients presented with lower radioiodine to that of control patients，the overall success rate

was not significantly different between these two groups（P＞0.05）．Conclusion The results of the treatment of patients with a

low iodine uptake are similar to the results obtained in the group of patients with iodine uptake above30%and therefore low iodine uptake should not be a contraindication for isotope131I therapy．

【Key words】hyperthyroidism；low radioiodine uptake；radioiodine therapy

131I治疗甲亢一次性治愈率高，复发率低，不良反应小［1］，不影响患者生活。国内多数131I治疗甲亢，其

参考文献：

［1］Virgili G，Menchini F，Dimastrogiovanni AF，et al．Optical coherence tomography versus stereoscopic fundus photography or biomicroscopy

for diagnosing diabetic macular edema：a systematic review［J］．Inves-

tigative ophthalmology＆visual science，2007，48（11）：4963

［2］Browning DJ，Mcowen MD，Bowen RM．Comparison of the clinical di-agnosis of diabetic macular edema with diagnosis by optical coherence

tomography［J］．Ophthalmology，2004，111（4）：712 715

［3］Goebel W，Kretzchmar-Gross T．Retinal thickness in diabetic retinop-athy：a study using optical coherence tomography（OCT）［J］．Retina，2002，22（6）：759

［4］Lee SBOK，Yun YJUN，Kim SH，et al．Changes in macular thickness after panretinal photocoagulation in patients with severe diabetic reti-

nopathy and no macular edema［J］．RETINA，2010，30（5）：756［5］Mcdonald H R，Schatz H．Visual loss following panretinal photocoagu-lation for proliferative diabetic retinopathy［J］．Ophthalmology，1985，

92（3）：388

［6］Henricsson M，Heijl A．The effect of panretinal laser photocoagulation on visual acuity，visual fields and on subjective visual impairment in preproliferative and early proliferative diabetic retinopathy［J］．Acta Ophthalmologica，1994，72（5）：570 575

［7］Mcdonald HR，Schatz H．Macular edema following panretinal photoco-agulation［J］．Retina，1985，5（1）：5

［8］Shimura M，Yasuda K，Nakazawa T，et al．Quantifying alterations of macular thickness before and after panretinal photocoagulation in pa-tients with severe diabetic retinopathy and good vision［J］．Ophthal-mology，2003，110（12）：2386 2394

［9］Klein R，Klein BEK，Moss SE，et al．Glycosylated hemoglobin pre-dicts the incidence and progression of diabetic retinopathy［J］．JAMA：

The Journal of the American Medical Association，1988，260（19）：

2864

（收稿日期：2012-04-12）