基于数据挖掘分析易无庸教授治疗慢性肾衰随诊6年中药处方
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摘要 目的:基于数据挖掘技术回顾性分析易无庸教授治疗慢性肾衰竭随诊 6年中药处方用药规律。方法:收集 2012年 1月至 2018年 8月于易无庸教授门诊处随诊 6年的慢性肾衰患者所开具的中药处方及门诊病例资料,通过 Python进行一 维及二维的数据分析、运用 FPgrowth算法得出频次前 1000的多维数据分析;使用 Gephi软件分层可视化网络图,总结出 用药规律及特点。结果:处方中,共用到中药饮片 267味,使用频率最高的中药为黄芪(970%);用药结构分析显示,药性 方面温药(410%)、寒药(360%)使用频率最高;药味方面甘味药(324%)、苦味药(302%)使用频率最高;药性归经方 面入肝经之药(194%)使用频率最高;药物类别方面补虚药(509%)使用频率最高,其次为活血药(177%)。三维、四 维分析组合最高的分别是黄芪、牡丹皮、麸炒枳实;黄芪、牡丹皮、麸炒枳实、熟大黄;黄芪、牡丹皮、麸炒枳实、熟大黄、熟地 黄。结论:易无庸教授在慢性肾功能衰竭长期治疗上用药主要遵循寒温并用,甘苦共调,益气扶正、补肾活血、疏肝理气、 通腑泄浊、健脾祛湿之法,与中医治疗理论相匹配,可为慢性肾衰竭的中药治疗提供参考。 关键词 数据挖掘;慢性肾衰;中药处方;用药分析;@易无庸;随诊
AnalysisofTraditionalChineseMedicinePrescriptionforChronicRenalFailureFollowingup 6YearsbyProfessorYiWuyong:BasedonDataMining
ChenZhihong1,LuChunjian1,YuanChanjian2,ChaiYuchun1,YiWuyong2 (1TheFourthClinicalMedicalCollegeofGuangzhouUniversityofChineseMedicine,Shenzhen518000,China;
·15wenku.baidu.com8·
WORLDCHINESEMEDICINE June2019,Vol.14,No.6
基于数据挖掘分析易无庸教授治疗 慢性肾衰随诊 6年中药处方
陈志红1 卢春键1 袁常健1 蔡玉纯1 易无庸2
(1广州中医药大学第四临床医学院,深圳,518000;2广州中医药大学附属深圳市中医院,深圳,518000)
2ShenzhenTraditionalChineseMedicineHospitalAffiliatedtoGuangzhouUniversity ofTraditionalChineseMedicine,Shenzhen518000,China)
Abstract Objective:ToretrospectivelyanalyzetheruleofprescriptionoftraditionalChinesemedicine(TCM)inchronicrenal failure(CRF)with6yearsfollowuptreatedbyProfessorYiWuyongbasedondataminingtechnique.Methods:FromJanuary2012 toAugust2018,theprescriptionsoftraditionalChinesemedicineandthedataofoutpatientcaseswerecollectedfromtheoutpatient departmentofProfessorYiWuyongfor6years,andthedataofonedimensionandtwodimensionswereanalyzedbyPython.The FPgrowthalgorithmwasusedtogetthefrequencyofthefirst1000multidimensionaldataanalysis;Gephisoftwarewasusedtovis ualizethenetworkdiagram,thelawandcharacteristicsofdruguseweresummarized.Results:Intheprescription,267kindsofChi nesemedicinepieceswereused.ThemostfrequentlyusedChinesemedicinewasRadixAstragaliseuHedysari(970%),thestruc tureanalysisshowedthatthepropertyofwarmmedicine(410%)andthecoldmedicine(360%)werethemostfrequentlyused.In theflavoraspect,sweetmedicine(324%)andbittermedicine(302%)wereusedmostfrequently.Inthechanneltropism,the medicineintotheliverchannel(194%)wasthemostfrequentlyused.Thedrugsoftonifyingdeficiency(509%)werethemost frequentlyused,followedbybloodactivatingdrugs(177%).Thehighestthreedimensionalandfourdimensionalanalysiscombina tionswereRadixAstragaliseuHedysari,CortexMoutanRadicis,friedFructusAurantiiImmaturus;RadixAstragaliseuHedysari, CortexMoutanRadicis,friedFructusAurantiiImmaturus,RadixetRhizomaRhei;AstragaliseuHedysari,CortexMoutanRadicis, friedFructusAurantiiImmaturus,RadixetRhizomaRhei,RadixRehmanniaePreparata.Conclusion:ProfessorYiWuyong′streat mentofchronicrenalfailureismainlyinaccordancewiththecombinationofcoldandwarm,adjustmentofsweetandbitter,tonify ingqiandstrengtheninghealthyqi,invigoratingthekidneyandpromotingbloodcirculation,soothingtheliverandregulatingqi, dredgingvisceraandremovingturbidity,invigoratingspleenandremovingdampness,whichmatchesthetheoryoftraditionalChi nesemedicinetreatment.Itcanprovideareferenceforthetreatmentofchronicrenalfailure. KeyWords Datamining;Chronicrenalfailure;Chinesemedicineprescription;AnalysisofprescriptionoftraditionalChinese medicine;YiWuyong;Followupvisit 中图分类号:R2565 文献标识码:A doi:10.3969/j.issn.1673-7202.2019.06.054
AnalysisofTraditionalChineseMedicinePrescriptionforChronicRenalFailureFollowingup 6YearsbyProfessorYiWuyong:BasedonDataMining
ChenZhihong1,LuChunjian1,YuanChanjian2,ChaiYuchun1,YiWuyong2 (1TheFourthClinicalMedicalCollegeofGuangzhouUniversityofChineseMedicine,Shenzhen518000,China;
·15wenku.baidu.com8·
WORLDCHINESEMEDICINE June2019,Vol.14,No.6
基于数据挖掘分析易无庸教授治疗 慢性肾衰随诊 6年中药处方
陈志红1 卢春键1 袁常健1 蔡玉纯1 易无庸2
(1广州中医药大学第四临床医学院,深圳,518000;2广州中医药大学附属深圳市中医院,深圳,518000)
2ShenzhenTraditionalChineseMedicineHospitalAffiliatedtoGuangzhouUniversity ofTraditionalChineseMedicine,Shenzhen518000,China)
Abstract Objective:ToretrospectivelyanalyzetheruleofprescriptionoftraditionalChinesemedicine(TCM)inchronicrenal failure(CRF)with6yearsfollowuptreatedbyProfessorYiWuyongbasedondataminingtechnique.Methods:FromJanuary2012 toAugust2018,theprescriptionsoftraditionalChinesemedicineandthedataofoutpatientcaseswerecollectedfromtheoutpatient departmentofProfessorYiWuyongfor6years,andthedataofonedimensionandtwodimensionswereanalyzedbyPython.The FPgrowthalgorithmwasusedtogetthefrequencyofthefirst1000multidimensionaldataanalysis;Gephisoftwarewasusedtovis ualizethenetworkdiagram,thelawandcharacteristicsofdruguseweresummarized.Results:Intheprescription,267kindsofChi nesemedicinepieceswereused.ThemostfrequentlyusedChinesemedicinewasRadixAstragaliseuHedysari(970%),thestruc tureanalysisshowedthatthepropertyofwarmmedicine(410%)andthecoldmedicine(360%)werethemostfrequentlyused.In theflavoraspect,sweetmedicine(324%)andbittermedicine(302%)wereusedmostfrequently.Inthechanneltropism,the medicineintotheliverchannel(194%)wasthemostfrequentlyused.Thedrugsoftonifyingdeficiency(509%)werethemost frequentlyused,followedbybloodactivatingdrugs(177%).Thehighestthreedimensionalandfourdimensionalanalysiscombina tionswereRadixAstragaliseuHedysari,CortexMoutanRadicis,friedFructusAurantiiImmaturus;RadixAstragaliseuHedysari, CortexMoutanRadicis,friedFructusAurantiiImmaturus,RadixetRhizomaRhei;AstragaliseuHedysari,CortexMoutanRadicis, friedFructusAurantiiImmaturus,RadixetRhizomaRhei,RadixRehmanniaePreparata.Conclusion:ProfessorYiWuyong′streat mentofchronicrenalfailureismainlyinaccordancewiththecombinationofcoldandwarm,adjustmentofsweetandbitter,tonify ingqiandstrengtheninghealthyqi,invigoratingthekidneyandpromotingbloodcirculation,soothingtheliverandregulatingqi, dredgingvisceraandremovingturbidity,invigoratingspleenandremovingdampness,whichmatchesthetheoryoftraditionalChi nesemedicinetreatment.Itcanprovideareferenceforthetreatmentofchronicrenalfailure. KeyWords Datamining;Chronicrenalfailure;Chinesemedicineprescription;AnalysisofprescriptionoftraditionalChinese medicine;YiWuyong;Followupvisit 中图分类号:R2565 文献标识码:A doi:10.3969/j.issn.1673-7202.2019.06.054